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The Large and Nifty Not-quite-advanced Drug Chemistry, Pharmacology and More Thread

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I'm not sure whether this deserves its own thread, so I'll try here first. I've recently become a big fan of 2-fluoroamphetamine. Unfortunately, 2-FA is by far the most obscure RC that I've tried, and there seems to be a real dearth of good information online about potential health risks. I seem to remember reading in a few places that the fluoroamphetamines in general were surprisingly lacking in neurotoxicity, but what other pitfalls should I be looking out for?
 
UYI said:
Any information available regarding:

5-Methylbutylone / 1-(benzo[d][1,3]dioxol-5-yl)-2-(dimethylamino)butan-1-one

Could anyone post a structure of this chemical please?
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That's weird. 1-(benzo[d][1,3]dioxol-5-yl)-2-(dimethylamino)butan-1-one is not 5-methylbutylone, it's n-methylbutylone. 5-methylbutylone is:
 

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Could the n-phenyl-propionanilide in fentanyl be replaced with a benzoyl group while retaining mu-agonist activity?

ie. n-phenethyl-4-benzoylpiperidine.
 
Very unlikely that opioid activity will be remained.

But your suggested compound is a reported 5HT2A-antagonist (a reduced version of ketanserine), Ki = 9.6 +/- 3.6 nM.
Ref: Glennon et al: J Med Chem 1995, 38(7), p.1196.


YO! - Murphy
 
MurphyClox said:
Very unlikely that opioid activity will be remained.

But your suggested compound is a reported 5HT2A-antagonist (a reduced version of ketanserine), Ki = 9.6 +/- 3.6 nM.
Ref: Glennon et al: J Med Chem 1995, 38(7), p.1196.


YO! - Murphy
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Interesting. Thanks again murphy!
 
ppl of advanced drugs i just wanted to take the time to invite yall down to my section of bluelight. we have an amazing group of ppl down there and many light hearted and serious discussion threads about the social aspects of drugs along with current trends. iam taking the time this morning to visit each forum on BL to give everyone a hardy welcome and join us. so remember north & south america drug discussion & social, long name awesome group of ppl.

hope to see yall around
 
I understand that inhibition prevents re-uptake causing less transmitters to leave the synaptic cleft and I'd like to guess that releasing of transmitters would occur through a transporter to the synapses. Both of these events increase the amount of a designated neurotransmitter's activity over a period of time, but what are their important differences?

E.G.: comparison of methylphenidate (inhibitor) to amphetamine (releaser)
 
dread said:
http://en.wikipedia.org/wiki/Calcium_morphenate

How does morphine form a salt with calcium? Aren't they both bases?
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The salt is used to extract morphine from the dissolved opium latex? This is what I was trying to do with another base in my (failed) voacangine extraction project (thanx Vektor: I was too discouraged to respond to your post a couple months ago).

As long as the pH of the solution is higher than the pKa of the *protonated* amine, the amine will not abstract protons from the solution. After that, what Murphy said.

Question: what's the pKb of carbonate (the *diprotonated* conjugate base of carbonic acid)? I confess I am in a depressive funk right now and have forgotten how to look up pKb's of conjugate bases of weak diprotic acids.
 
morphine sulfate IR v. norco 10/325 mg

http://www.bluelight.ru/vb/showthread.php?t=520656

I posted my question in TDS but was told maybe someone here could answer it.

Was wondering if I can use norco when I run out of the morphine sulfate IR 15 mg pills for my taper. I have a bunch of those left and am avoiding going back to the PM dr if possible. No reason other than I figure to be off all opiates mid September at the latest and just trying to save the time spent dealing with an appointment.

I only take the MS IR every 8 hours. Currently at 22.5mg, 7.5 mg, 30 mg. A bit more than a week ago I was at 30, 30, 30 and Doctor wanted me to taper to 15, 15, 15 this week. Went through bad WD's in July and don't want to go there again. For the record I am taking myself off the meds and the dr thinks I need to remain on them.
 
Help me please said:
I'm unclear. You say take one norco every 8 hours but once I am at what morphine dose? If I did that at any but my 4 pm, 7.5 mg dose now I would go into WD.
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Hydrocodone has about the same oral potency as morphine. Just stick to your tapering schedule when you switch to the norcos. Good luck man.
 
15mg of oral morphine sulfate is about 10mg of hydrocodone and might even be a bit less.

So one 15mg morphine pill = 1 10mg hydro pill.

Just start taking less and less of the hydros....
 
I am pretty sure hydro is stronger on a mg per mg basis than morph sulfate. I know I would rather have 100mg of hydro than 100mg of oral morphine. IV morphine is a different animal, as we all know..
 
LawnChairSkank said:
Hydrocodone has about the same oral potency as morphine. Just stick to your tapering schedule when you switch to the norcos. Good luck man.
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Thank you. I do wonder whether once I am that low if it will matter at all. I mean I will have to cut the norcos in 1/4's and which takes me to 2.5 mg doses. The MS IR was to drop to 3.75 mg doses at some point. Maybe when I get to the 3.5 on the morphine I can just go to half a norco and see from there. It would be easier to do that in the long run...maybe :)
 
smackem said:
15mg of oral morphine sulfate is about 10mg of hydrocodone and might even be a bit less.

So one 15mg morphine pill = 1 10mg hydro pill.

Just start taking less and less of the hydros....
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Wow, I am hearing two totally different opinions on the m v n issue. I will call my pharmacist in the morning to make sure. I need to do a pill count too and see how the new taper schedule adds up. I am tapering less mg-wise but more often too. I'm tired and confusing myself let alone all you guys :)

Thanks <3
 
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