anyone know if there are any risks involved combining seroquel and ketamine? tomorrow im gonna trip (LSD) and probably get through a large amount of ketamine too, and use seroquel to put me out at the end of the night. couldn't find anything on k+seroquel
Ok so probably a day late but anyway: Seroquel aka Quetiapine is not as user friendly as typical benzo's (despite being a distant inbred relative). One issue is quetiapine may lower seizure threshold. Another is neuroleptic malignant syndrome a rare and potentially fatal complication. It is characterised by the following symptoms: tremor, rigidity, hyperthermia, tachycardia, mental status changes (e.g. confusion), etc. So a brief outline of receptor site activity:
D1 (IC50 = 1268nM), D2 (IC50 = 329nM), D3, and D4 receptor antagonist
5-HT1A (IC50 = 717nM) partial agonist, 5-HT2A (IC50 = 148nM), 5-HT2C, and 5-HT7 receptor antagonist
α1-adrenergic (IC50 = 94nM) and α2-adrenergic receptor (IC50 = 271nM) antagonist
H1 receptor (IC50 = 30nM) antagonist
mACh receptor (IC50 = >5000nM) antagonist
As you can see it has antagonist action with dopamine, serotonin and adrenergic activity. A small amount of Quetiapine (25 mg) is probably ok at the end of the evening for sleep. LSD and K are not great in combination as LSD due to it's mode of action tends to raise body temp combined with K reducing your ability to sweat ok if your careful with doses but I know what happens when you have a gram of K and a few tabs of LSD and party mode switch is on. Hyperthermia may result. Also LSD and K may result in serotonin syndrome if dosed excessively. Add seroquel and shit may go from bad to worse. 25-50 mg after the LSD has worn off and the K has run out and sleep is desired and a few dozen cones smoked might be ok but I'd be careful. No way in hell would I advise any greater than 50 mg and even then it's with a great deal of hesitation considering that K can cause neuro toxicity for 24 hours post ingestion and you have LSD being metabolized and excreted as well.
Hope everything turned out fine and you don't have serotonin syndrome/toxicity, got a good night/days sleep and everything went well and most important you had fun.
Going to give IVing K a go just to try it out. Don't IV anything these days but never IV'd K due to the whole druggie lore re: hits so hard the pick will still be in there. Can get some really pure shit atm so why the hell not? At least then I can give an objective and subjective report on this ROA.