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Opioids The Grapefruit Juice Myth

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Chubs4You

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Oct 24, 2016
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I am a medical professional and have seen a lot of talk about grapefruit juice on various sites. Please trust me--don't ever drink grapefruit juice with methadone, benzodiazepines, and any other drug it interacts with. There is a myth that grapefruit juice makes the drug more intense, but the opposite is true. It inhibits absorption of these drugs and will give you less of a high. Just an FYI.
 
Wrong. It inhibits the enzymes that metabolize the drug, thus allowing more of it to be absorbed.

I will agree that people shouldn't utilize this practice though, you know hr and all.
 
7nos-SS373dOH said:
Wrong. It inhibits the enzymes that metabolize the drug, thus allowing more of it to be absorbed.
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This
White grapefruit juice contains a substance called bergamottin, it's a CYP3A4 (and probably a few other isoforms of the cytochrome P450 enzyme) inhibitor.
Of course it'll decrease the effects of pro-drugs that need to be metabolized into an active drug, but if you take a drug that's metabolized into an inactive metabolite by CYP3A4 the drug will last longer, and maybe will be a bit more potent.
 
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My Apologies

kleinerkiffer said:
This
White grapefruit juice contains a substance called bergamottin, it's a CYP3A4 (and probably a few other isoforms of the cytochrome P450 enzyme) inhibitor.
Of course it'll decrease the effects of pro-drugs that need to be metabolized into an active drug, but if you take a drug that's metabolized into an inactive metabolite by CYP3A4 the drug will last longer, and maybe will be a bit more potent.
There are enough medical papers about it, so don't tell us you're a medical professional...
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I really didn't mean to sound snobby when I said I was a medical professional. Maybe it came off as cocky, but I didn't intend to. I didn't want to say exactly what my occupation is, but I just learned about the grapefruit juice contraindications last week as part of my continuing education. My apologies for sounding like an arrogant know-it-all.
 
^Sorry on my part, I was rude, had a rough day


Could you tell us more about what you learned, because from what I know it does potentiate certain drugs to a small extend
 
No Worries--Rough Day For Me Too

kleinerkiffer said:
^Sorry on my part, I was rude, had a rough day


Could you tell us more about what you learned, because from what I know it does potentiate certain drugs to a small extend
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Oh, it's totally OK. I really appreciate it. I am so stressed out this week myself. Lol. I feel like there's so much to do and it is just not possible in the time I have to do it. Anyway, I was told that grapefruit juice lowers the potency of benzodiazepines. However, I made the mistake of assuming that grapefruit juice would have the same effect on other drugs. So, from what I was told, benzos become less potent if taken with grapefruit juice. I'm going to ask one of the pharmacists I know exactly what effects grapefruit has on which drugs.
 
I know you're not supposed to drink grapefruit juice if you're on certain medications, but I don't think any of them are recreational.
 
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