• N&PD Moderators: Skorpio

the fun is just beginning

Deuterium in the form of heavy water is now cheap, and most of the places in the structure where you want to put deuterium are places amenable to using simple inorganic deuterium compounds as the D source. for example LiAlD4 or D2 gas or whatever.

Deuterium is not partiularly toxic, we know this because of the now infamous water cooler incident , a disgruntled worker spiked the water cooler at a research institution with D2O, and for quite some time people drank it, there were no reported adverse effects, though the heavy water also contained trace of tritiated water which is highly dangerous.

Deuterium only shows up as a problem once a large percentage of the bodies' water is heavy then it slows up metabolism and causes toxicity, indeed it has been speculated that using heavy water or better heavy proteins might be a way to enhance longevity.

I have also heard of D2O ice being used to make ice cubes that sink in alcoholic drinks like gin and tonic, though it may be apocryphal. the theory is good, alcoholic mixtures are less dense than water so the cubes don't have to contain 100% heavy water to sink and there are thousands of gallons of heavy water around in labs and research insitutes and it is pretty easy to 'liberate' a few hundred ml.

it is highly unlikely that the average cook will be making any heavy drugs anytime soon, but it might appear in the custom made drugs that olympic class athletes use.
 
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^^^That is a good idea; deuterated anabolic-androgenic steroids would be perfect for competition sports. Life may get harder for doctor Don Catlin...
 
Then, just in no time the standard data point for mass-spectrometer will change from molecular weight point to molecular weight "range"!
 
^ can't work like that, because the fragments that are used to identify the drug will also change, and simply using the molecular ion weight is unacceptable,
say a drug has the molecular formula C12H14N2O2
There are thousands, if not milions of possible structures with the correct mass, hence the need to use the fragment weights and fragmentation pattern, as a fingerprint, deuterated drugs screw with all of that.

the algorithms inside for example Chemstation (Agilent) and similar products from other manufacturers match relative abundance and weight, and are very weak, and easily confused.

It would seem that the forensics are going to have to switch to using retention times rather than ms spectra, which in turn means that they are going to have to physically run the references on their machines rather than relying on stored data, because of the variance column to column machine to machine.
 
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