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The effects of adding specific elements or groups to benzos

immaturepoop said:
its called thiophene, but are the thienobenzodiazepines usually more euphoric from experience? I've haven't tried any of them, but how would you compare it to the more common benzos or even hypnotics Jamshyd?
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Thienobenzodiazepines = horrible (olanzapine for example)...

Etizolam is a thienotriazolodiazepine...
 
Olanzapine and clozapine also have a methylpiperazine group (and clozapine doesn't have a thiophene ring).

Has anyone taken brotizolam or clotiazepam?
 
negrogesic said:
Thienobenzodiazepines = horrible (olanzapine for example)...

Etizolam is a thienotriazolodiazepine...
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Yep, it is the latter.

As for the effects, I will tell you one thing for sure: it has a definite mood-lifting/warm feeling to it that is absent from all other benzos. As for which benzos it most resembles, to me, it feels a lot like lorazepam: strong but light at the same time (ie. not "stupefying" like alprazolam or clonazepam). But the mood-lift was the most striking aspect.

I tried another member of this group, Brotizolam (to answer your question, bupropion). It seemed to lack the mood-lifting "euphoria" of the former, but it is still high on my liking list.
 
Olanzapine just looks like a modified tricyclic. I wonder how it'd do without that extra ring and an oxygen properly located.
 
On a benzo or on olanzapine?

I don't see how it'd offer any benefit; it's obviously not going to suddenly turn it into an entactogen. Lot of people see it and all of a sudden think you can weld one onto anything and have the next MDMA mimic. I'm not sure if that's what your thinking is.

I'd be more interested in trying it in place of the traditional benzene. Have any nitrogen-containing rings been tried there? Or any non-aromatic rings in place of that phenyl group?
 
Bromazepam and related have a pyridine in place of the phenyl - seems to lead to atypical metabolic routes.

I'd imagine the main benzene ring is not replaceable with anything but thiophene somehow.
 
I'd imagine the main benzene ring is not replaceable with anything but thiophene somehow.
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I don't know about that, with a lot of these depressants it seems that an exceptionally wide range of changes can be made, as long as you're not messing with the CC(=O)N structure (or, apparently, the easily oxidized =S) and the general shape and conformation of the molecule remains.

Does anyone know how Cyprazepam is metabolised? To my eye it looks like a prodrug, but I'd like to know that for sure or not. If not, I bet it's got a unique binding profile.
 
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