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Miscellaneous The Big & Dandy Psychedelics of the Future Thread

Well, 2C-B-fly's duration is not all that much longer than 2C-B's... maybe twice as long at most. Less in my experience. I'd still love to see 2C-E-fly.
 
Why wont some fucker make the beta-methylene (ring substituted 2-phenyl-3-aminobutenes/2-phenyl-3-aminopropenes) compounds I suggested a long time ago. If they're worried i'd be willing to put my money where my mouth is and be the human guinea-pig (I have that much faith!)
 
hugo24 said:
On the fly's,since they have a much increased duration,it cuts the selection mainly to 2C-D,2C-T,maybe 2C-T-2 and DOM fly just for historical reasons.
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I'm dying for 2C-D-fly. Hell, I'd be happy if someone would just put some plain old 2C-D back on the market. Bring it on!

I didn't find the increased duration of 2C-B-fly a problem. In my experience, the effects are so pleasant that the time goes by plenty quickly.
 
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djfriendly-yeah 2C-B-Fly put duration just into the ballpark.I just worry a bit that for example with 2C-E,P,T-7 and so it could be extendended into the 18-20h,just a bit too much for me.

Poor old bulbous still waiting for his Styren...yeah the superpotent cyclobuten isn't electronically that far off from it.Maybe you should write Dave?
 
I'm dying for 2C-D-fly. Hell, I'd be happy if someone would just put some plain old 2C-D back on the market. Bring it on!
Click to expand...

I'd go with 2C-D-fly purely because it's not controlled in the UK whereas 2C-D is (in fact all of the 2C-x's are). DOM-fly would be somewhat appreciated as well, if it were ever to show itself!
 
Have any of the DOx-fly's ever been marketed? I seem to remember a mention or two (perhaps from you f&b) of DOB-fly, but nothing much.
 
To hell with all these boring phenethylamines, I want to see some Lysergic Acid Amides on the market!
 
DOB-Fly was made available to the public by two separate companies, with the dosing of the racemic falling between 250-1000mcg (IV/SC) and 500-1500mcg (oral). The duration was reportedly about the same or not much longer than DOB itself, which is curious. The body might have some quicker way of working through the molecule when the alpha-methyl extension exists.

>>Heckyll
You and me both!
 
Hm, I've only ever heard of 2C-B-fly and DOB-dragonfly having been available. I've seen mention of DOB-fly in papers, but not on forums.
 
^^ I'm pretty sure most of what was made available was the racemic non-aromatised DOB-Fly rather than DOB-DFly (because of toxicity concerns). But, maybe not?
 
I thought it was DOB-DFLY that was on the market as well, but then I never say any actual analysis.

Boring PEAs? Heh whatever. PEAs are the best. Only LSAs that would interest me are ones with a much shorter durtation than LSD.
 
Dr.Heckyll said:
To hell with all these boring phenethylamines, I want to see some Lysergic Acid Amides on the market!
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+1

Although I don't find the phenethylamines to be boring. Well, certainly not all of them.
 
I often find solo phenethylamine trips to be more comfortable and rewarding than tryptamine experiances, which I seem to get the most out of in a small group setting, outdoors, such as camping. I certainly would not be, however, in disagreement with some new lsa's!!
 
nuke said:
^^ I'm pretty sure most of what was made available was the racemic non-aromatised DOB-Fly rather than DOB-DFly (because of toxicity concerns). But, maybe not?
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The little vials in my freezer (which will probably never see the light of day) are marked 1-(8-bromobenzo[1,2-b;4,5-b']difuran-4-yl-2-aminopropane. Is this not DOB-dragonfly? I am under the impression that the non-aromatized fly's have "tetrahydrobenzo" in their IUPAC names referring to the ring substitutions.

If I'm wrong, then Erowid is wrong also. Sorry for the off-topic-ness...these damned fly's etc. confuse almost everybody, and I'm just trying to make sure we get the names correct.
 
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Yeah, you are right, I guess I'm wrong again then. Apologies.

also mildly OT: does anyone have computer imagery of a PEA binding to a 5HT2A receptor?
 
Figure 1. (A) Top view of mescaline (1) virtually docked into the 5-HT2A receptor homology model with key residues known to be important for
binding. (B) Similar view of the docked R-enantiomer of 2. The view is from the extracellular face of the receptor, with ASP155 in TM3, PHE243
in TM5, and PHE339 and PHE340 in TM6.
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C-(4,5,6-trimethoxyindan-1-yl)methanamine: a mescaline analogue designed using a homology model of the 5-HT2A receptor. McLean TH, Chambers JJ, Parrish JC, Braden MR, Marona-Lewicka D, Kurrasch-Orbaugh D, Nichols DE.
 
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Thanks, I'd been wanting to see how a PEA binded since I saw that 2003 paper where they did a bunch of tryptamines.
 
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