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The Big & Dandy Nootropics Thread

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Anyone have experience with N-acetyl-L-tyrosine? Is it really all that much better than plain old L-tyrosine? I'm going to be adding phenylalanine and tyrosine to my stack(planing on alternating bewteen them), and I'd be willing to spring for the NALT if it's really worth it.
 
Anyone have experience with N-acetyl-L-tyrosine? Is it really all that much better than plain old L-tyrosine? I'm going to be adding phenylalanine and tyrosine to my stack(planing on alternating bewteen them), and I'd be willing to spring for the NALT if it's really worth it.

All I know is when I drink Focus XT (contains regular tyrosine) before I go to work, it really gets my gears going almost like an extended coffee buzz that can sometimes last for hours; especially after you blaze.

Same deal with Cannabis and Energy Drinks that contain similar mixtures. Makes it like a mild psychedelic amphetamine, really clear minded for the most part.
 
N-acetyl-L-tyrosine

Anyone have experience with N-acetyl-L-tyrosine? Is it really all that much better than plain old L-tyrosine? I'm going to be adding phenylalanine and tyrosine to my stack(planing on alternating bewteen them), and I'd be willing to spring for the NALT if it's really worth it.

phenylalanine is precursor to tyrosine so no point in taking both....

N-acetyl-L-tyrosine is suppose to be 20 times more water soluble than tyrosine, but i dont think its worth the cost.
Plus those amino's raise levels of 6-hydroxydopamine which is toxic to neurons...

To boost dopamine plus extra good stuff (neuroprotection) i think you can't go past deprenyl

Link: deprenyl and neuroprotection
http://www3.interscience.wiley.com/journal/89013536/abstract?CRETRY=1&SRETRY=0
 
Really? I heard it has some structural similarities to PEA or something. But I use it in combination with a number of PEAs and it definitely works that way.

wikipedia (no citation though) said:
Structurally, phenibut is gamma-aminobutyric acid with a phenyl group in the beta position. It has structural similarities to baclofen and phenethylamine. Phenibut is a GABAB receptor agonist, with slight activity at GABAA receptors. It also is a beta-phenylethylamine antagonist and thus reduces the effects of phenylethylamine and other compounds that raise phenylethylamine levels. Furthermore, it has shown to stimulate dopamine receptors. The pharmacological effects of phenibut are similar to baclofen, but less potent on a per milligram dosage.

220px-Phenibut.png


It is phenethylamine with an ethanoic acid group sticking off the side.

I definitely notice both calming and stimulant properties with phenibut. The stimulating properties can get quite noticeable at times. I would certainly not be surprised to find out it metabolizes to PEA in the brain and therefore exerts PEA effects. I'm not sure about that sentence in the wikipedia quote about it being a PEA antagonist and then going on to say it stimulates dopamine receptors. It definitely has an upper side; that can't be denied (for me anyways)
 
Do you find a choline precursor like citicholine or alpha-gpc to be necessary when using piracetam daily? It seems that some people get headaches from piracetam without taking choline supplements. Citicholine is pretty damn expensive though, so I'm going to try using piracetam only for a while.
 
Do you find a choline precursor like citicholine or alpha-gpc to be necessary when using piracetam daily?


Not necessarily...
some people do not experience headaches or unpleasant effects without the choline

Try the piracetam by itself
If you get headaches take a choline source...
Choline citrate is a good cost effective source
 
Ok so I received my Piracetam yesterday. I took an attack dose of 2.4g in the afternoon. After about an hour and a half I did feel a general sense of clarity, excitement, and creative thought. I couldn't really stop smiling as everything seemed entirely interesting. I walked around my property feeling great to be outdoors listening to great music on my headphones. Musical perception seemed to be increased, and I had a better awareness on various musical elements and how they drove the song forward (The Chemical Brothers).

About an hour after I took the Piracetam, I took an Adderall XR but crushed up the beads and drank it in water. After an hour I was a workaholic and was able to complete four hours of Spanish coursework with no problem. But this is beside the point, I'm just curious if Adderall combined with Piracetam had mad a certain effect.

Today in the morning I took another 2.4g dose. I did not feel much effect other then feeling fairly clear and not as tired as I usually do. Strangely, I got four hours of sleep last night after taking the Adderall, yet I did not feel that tired. I took another 2.4g of Piracetam at around noon, and have not felt that much effect. I do feel very tired right now from sleep exhaustion, so maybe it is clouding the Piracetam effect.

I'm wondering if I should take a 3.2g x2 tomorrow to see if I notice any better effect with a higher attack dose? Or should I just continue the 4.8g per day for the next couple days then reduce to 800mg twice daily?

I just ordered some Centrophenoxine in 250mg tablets. I should receive this in about two weeks, so I suppose by then I will have a better understanding of how Piracetam is working for me, so I can add another Nootropic. After this I plan to get Hydergine once I get paid, and start taking it in around 3-4 weeks. I figure these three Nootropics combined with Flax seed oil for my Omegas, and a natural multi-vitamin will be enough.

Any thoughts/suggestions?
 
*bump* anyone? Took 3.2g today around 6am. Felt pretty decent after about two hours or so after consumption. Either it is a placebo or Piracetam really makes me want to smile a lot. Things like paintings of Indian art at my work make my grin spread so much it hurts. But this feeling lasts for about an hour.

I have felt pretty clear headed and efficient.
 
i take about 2.5 grams 3x a day. ime i wouldnt say this is necessarily an affect of piracetam. perhaps you are just having a great day! i wasn't noticing its affects until around the second week. i feel that i experience clear thinking because of my piracetam routine.

either way you're feeling good and that's great! but since you have just started your piracetam regimen i'd wouldnt say its entirely piracetam in action
 
i take about 2.5 grams 3x a day. ime i wouldnt say this is necessarily an affect of piracetam. perhaps you are just having a great day! i wasn't noticing its affects until around the second week. i feel that i experience clear thinking because of my piracetam routine.

either way you're feeling good and that's great! but since you have just started your piracetam regimen i'd wouldnt say its entirely piracetam in action

Thanks for the reply. I have been in such great moods for about two months now. This is amazing for me, as I usually fall into depression quite easily. I cut out my antidepressants and mood stabilizers I was taking after this dope Psychiatrist thought I may have a mood disorder. It has been very easy to reprogram my emotions into positive thinking lately, so when I do get into a negative swing, I know how to get it back on track or at least a neutral state.

So now that I believe I have a stronger grounding in positive mental attitude, I figured I would try Nootropics to clear out some of the fogginess and lethargy I feel.

It has been hard to see if I feel the effects of Piracetam yet, but there is one distinct feeling that has been unique since taking the supplement. One to two hours after consumption, I feel that really strong desire to smile at everything. I let myself focus on various images or activities, like my dogs interacting with each other with their distinct personalities, and am able to hold this concentration with ease. It feels like my imagination starts to flow more easily and I can create more interesting linguistic phrases in my mind or on paper or have more intricate ideas that actually develop off of itself, instead of usually just dropping an idea after a couple mins.

It feels like I am more able to focus on music or art while analyzing their elements without taking away from the perceptual awareness of the object. To me, that sounds like I am using both hemispheres of my brain more casually.

But it could all be a placebo effect that I am experiencing. I have researched the effects of Piracetam quite thoroughly, so I may be subconsciously telling my brain to act in these ways. Regardless, I'll see how I feel in the coming weeks.
 
Two questions:

1. Has anyone else noticed L-Tyrosine producing headaches?

2. In response to uniters info on phenibut: would phenibut be effective as a sort of antidote or effect reducer when you took a psychedelic phenethylamine? I know it has a pretty long period before the action starts but say you take the phenibut in anticipation of the PEAs comedown can it prevent lingering stimulation or something? Allowing you to sleep immediately after the trip maybe?
 
Ah :)
Question 3. to add: How does it feel if you take piracetam for a year, then stop?
Do you feel stupid, a little depressed even, confused?
 
I started taking a lot supplements including twice a day 2 grams of piracetam and ginseng, ginkgo, my mind seems to be clearer then before :).

Will keep experimenting with more powerfull noots.
 
*bump* anyone? Took 3.2g today around 6am. Felt pretty decent after about two hours or so after consumption. Either it is a placebo or Piracetam really makes me want to smile a lot. Things like paintings of Indian art at my work make my grin spread so much it hurts. But this feeling lasts for about an hour.

I have felt pretty clear headed and efficient.

I actually find that too much piracetam reverses the cognitive enhancement, making me feel a bit scattered or clouded. Try taking 800-1200mg and see where that gets you. And it's important to engage your mind in tasks that utilize its full potential... if you take it and don't engage your brain, you won't notice the majority of the effects. It's not like a drug where you take it and feel it kick in and feel some sort of high or direct effects. You'll notice it's working when you realize that whatever you're thinking about comes really easily. The mental clutter cleans up and your thought process becomes more efficient. You can multi-task with ease and keep multiple ideas in mind at once. If I'm utilizing it full by engaging my mind (for example, programming, as I am a computer programmer), it makes me feel some excitement and a sense of being pleased, because I'm a cerebral sort of person and I get a kick out of observing the workings of my brain. :)

Ah :)
Question 3. to add: How does it feel if you take piracetam for a year, then stop?
Do you feel stupid, a little depressed even, confused?

Actually after daily use for too long, I feel that piracetam becomes counterproductive for a while. After I took it for a year or so daily, I noticed it made me feel a bit down, and I generally started feeling a bit run down and frazzled. Stopping reversed me back to normal, and so nowadays I take it just when needed. I may start another run, maybe a week on, a week off, or something, and see what that does for me.
 
Good to know mr Xork!
I find it a little strange when people go dosing piracetam too high too fast, but I can understand if someone wants to push it over time to keep noticing the effects. Personally I just rather not take it when my day doesn't look like I would really utilize it. That way I hope I won't become accomodated at least for some time longer.
With phenibut I use it on and off because of the withdrawals and stuff, although I love the stuff a little bit too much :D I can stop though, it's just that I feel a little disappointed when it's that time. Right now I'm not taking it for a while to save it for the start of coming new projects. Then it will be perfect!!!!!

Another question, 4 lol ;)
Does anyone have an idea why piracetam is not more popular (it's known for a while now), and more importantly: why is it not just OTC in a drug store / pharmacy? (At least where I live)
It makes people around me a little sceptical about it, and honestly I wonder myself what the deal is...
 
I have had a 500g tub of piracetam sitting around for a while but have never gotten around to trying it out.

Now that I am back at school doing a bunch of work I figure it might be a good time to give it a shot. The thing is, information on what exactly is the best way to take it is sparse and inconsistent IME.

What do you guys think would be a good dosing regimen? Many people say you have to take it everyday for a period of time to get good effects. Is an attack dose necessary? My tub says 2400mg 3-4 times a day which is definitely excessive.

I know that it also influences the effects of other substances, particularly psychedelics.

Can anyone give me an overview of exactly what substances it affects, whether it be potentiation or a dulling effect. How does it affect dissociatives, stimulants, opiates, alcohol? Cannabis?

How many days in advance would I have to stop taking it if I wanted to trip without it having any influence?

I know your supposed to take it with some kind of choline so I got some Alpha-GPC which is supposed to be a more efficient substitute/form.

Hopefully you guys can answer my questions and give me a little advice as to how to proceed.
 
Well I think the attack dose idea is for achieving as much effect as possible as fast as possible. Though after that, you probably get used to it that much faster.

What I did with my 500g tub is just start with 2 times a 500 mg dose, first one at the start of the day and the second one before or around noon / lunchtime. I definitely notice the effects.
I don't see why one should take it in a regimen except when you don't notice the effects well enough right away when taking it. Then daily usage can build up an effect over time, this buildup is exaggerated by attack doses or so it seems to me from what I read.

So if you ask me and my limited experience, the way to use it depends on what you notice from it when you just start taking a gram once a day for a couple of days! (So first start with that).
Another factor is if you want to have a sustained effect or if you're OK with it if there is only an effect on days you can actually use it. There is a good possibility if you don't take it when not needed you notice it that much more if you do use/need it. Even though this is a supplement it sounds logical to me that it gets less and less special if you insist on a constant effect.

Another question you may ask is: do I really need to notice it or is it just as nice if you don't notice it even though technically the effect is certainly there?? If you get what I mean.

Personally I really love it to actually feel my head become superclear, but if I was the kind of person not to notice such a thing... a mind that just functions more efficient, without my awareness of it, is the next best thing.
 
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