Natural psychedelics are superior in a number of ways in my opinion. You know they are not adulterated if you harvest them yourself. They have an extensive history of human experiementation. The varied alkaloidal content contributes to a more complex experience subjectively. Our plant friends are perfect at the chemistry they do, there are no unknow harmfull byproducts and the sythesis is exceedingly efficient tuned by thousands of years of natural selection for enzymatic processes. There is nary a chance of a person being unknowingly dosed and the liklihood of a massive overdose is reduced because plant material acts as a bult in cuting/measuring agent (one could argue that you never know your exact dose, which is true but look at the number of reports on acidental OD's of RC's versus cacti, mushrooms, cannabis, etc).
That is not to say sythetics are evil or harmfull by neccesity but you are definitely loading another round in the game of russian roulette when you play with sythetics. Even our oldest friend LSD is still a RC in my eyes, 50 years of self experimentation by mostly caucasian individuals in a handfull of nations is not what I would call an extensive knowledge base. The scientific literature is severely lacking because of its legality. In this respect natural chems have a sizable atvantage but synthetics can still be a godsend.