I have been using MXE in threshold doses for the antidepressant effect. I use about 90 - 100 mg for this, and I do have a medium sized tolerance to this type drug, based on others descriptions of their use. I cannot advocate it's use for this purpose due to lack of research and unknown long-term effects, but I can say it's been effective when nothing else has.
I experience a definite stimulation which is very noticable around four hours after dosing. I take it with 0.5 mg alprazolam, and often will take another 0.5 mg to reduce at least the subjective feeling of stimulation.
I am curious if anyone else has noticed this effect, and if it happens with ketamine at this dose(which is 0.5 mg/kG bodyweight).
I also am curious if anyone might know what is causing this. My ideas:
1) a form of
glutamate rebound(due to onset at approx. 4 hours)
2) an active metabolite (again due to time of onset)
3)the seratonigenic activity of MXE vs ketamine (if ketamine does not have this effect)
I notice that if I take anything remotely stimulating during this time, it will potentiate it to the point of unbearability. This includes D-amp, caffeine, and stimulating kratom. In fact, it even potentiates it the next morning, when the direct stimulating effect of MXE has been gone for ten hours. It also does not seem to interfere with sleep quality like glutamate rebound from alcohol.
It seems well known on drug boards that NMDA antagonists potentiate opiates (usually DXM is mentioned). Perhaps it sensitizes your receptors in some way. And this could be why it works as an antidepressant.
I get the feeling there is much unpublished research, and someone, somewhere knows a great deal about this, so cough it up.
