The Big & Dandy Methoxetamine Thread - Hit #12 - Oh look, it's MXE o'clock

[psood0nym]

the ondansetron is just for potential nausea, right? I mean, it's not contributing to any effects, right? lol

off-topic non-MXE post in NSFW tags:

NSFW:

No the ondansetron interacts with DXM in two ways I know: it both competes for the liver enzyme that metabolizes DXM into DXO and changes DXM's SSRI effects by antagonising 5-HT3. I'm not sure if either of these interactions is relevant to the special effects the combo has for me, which include ecstatic euphoria (stronger than any opiate or empathogen even) and highly amplified psychedelic effects (this requires 12 - 16 mg ondansetron, which is pretty high). Others who have tried the combo (4 that I know of) only report markedly increased lucidity relative to DXM alone, but unfortunately none have reported the effects I get, though it may be like opiate euphoria in that it takes multiple uses for it to fully develop. It seems to amplify serotonergic effects in me strongly, as I get muscle spasms in my legs, become more sensitive to heat and sweat more, and my pupils grow far more dilated than what the same dose of DXM alone does. I've not noticed any interaction of ondansetron with MXE, though. Ondansetron has off label anti-depressant uses as well. I only found out about it when I noticed all my DXM trips when I took ondansetron at 4mg just as an anti-emetic were of great quality, and usually DXM trips vary in quality quite a bit for me. So I tripled the ondansetron dose and zing! I overdid it for a while and ended up with brain zaps and so now I only do it every once in a while.

 

[Morkin]

^ Yes, MXE keeps me up too. It also make it hard to do basic stuff, like typing. So far, the best effects are lying down, alone & in the dark, just like with K.

 

[alantis360]

Same for me. I like to dose hiigh and i stagger my doses. Sometimes though I feel like it messes with my sleep for a week after.

I sometimes have an afterglow for just as long as well

 

[Thorns Have Roses]

No the ondansetron interacts with DXM in two ways I know: it both competes for the liver enzyme that metabolizes DXM into DXO

Perhaps not ¹:

The role played by CYP2D6 in the metabolism of ondansetron by human hepatic microsomes in vitro was shown to be minor

Multiple CYP450 enzymes are implicated in its metabolization ¹, with CYP2D6 really only working on the s-enantiomer ².

 

[psood0nym]

^Interesting, though I never imagined the known interactions were what was chiefly responsible for the extraordinary subjective state the combination affords me. If such a mechanism was all that was responsible eating grapefruit with DXM might be expected to cause ecstatic states in everybody.

 

[Morkin]

And I thought grapefruit was a no-no for this kind of shit...

 

[TheAppleCore]

I've no idea why I got such striking visuals at such a low dose this time.

I am reminded of your very intriguing finding - on DXM and MXE, was it? - that you could induce visuals by focusing your attention on a point of light in the periphery of your vision. Were you practicing this technique? I've yet to try it, and I'd really like to, but it's quite rare that I use dissociatives nowadays.

 

[T9358]

i personally when first getting into mxe had "real" visuals of the "dissociative" type- i watched a small packet of powder go from small to enormous, to oblong to microscopic all while holding it in my hand i thought i was ''holing'' with my eyes onpen as i had 100mg~ 6-apb a few hours before, this was a 100mg dose followed by another 2 60mg doeses 20min apart

 

[psood0nym]

I am reminded of your very intriguing finding - on DXM and MXE, was it? - that you could induce visuals by focusing your attention on a point of light in the periphery of your vision. Were you practicing this technique? I've yet to try it, and I'd really like to, but it's quite rare that I use dissociatives nowadays.

The first time it happened I quoted a few posts ago. Yes, it involved DXM (~400mg), ondansetron (16mg), and MXE (~100mg), as well as the technique described. I'm guessing the reason I was able to experience these visuals off of just 30 mg during this most recent experience owes to the reduction in tolerance after the two week break and an internalization of the technique described such that I do it almost automatically because my brain has had a lot more experience with MXE since that first post.

It involves attending to a point in your vision aside from what the center of your eye is pointed towards, which is to say focusing on the periphery. It's like watching out of the corner of your eye without looking for anything. You may have been presented with grid illusions in the past that demonstrate that the brain fills in the periphery of our vision with whatever pattern the optical focal point of our vision is focused on (in the case of the grid illusion an empty circle in the grid is filled in because the brain extrapolates the grid pattern over it). I think this idea of the periphery of our vision being the part that's less informed by the environment and more constructed by the brain is important to understanding why the technique worked for me. In making an effort to focus on the periphery of my vision I was making an effort to shift perception and observe the visual constructions of my brain rather than observe the dense aggregations of photons from the outer environment entering my cornea and causing highly defined reactions on my retina that result in standard optical perception of the environment. Attention is the "eye" referred to in my aural hallucination instructing me to "turn the eye within the eye" that first time I experienced the extraordinary visuals with MXE.

 

[DroneLore]

How much more potent do you people think MXE is when IMed compared to other ROAs? I cant imagine IMIng 150 mg but maybe my tolerance is still low.

edit: at least i cant imagine IMing 150 mg at once. ive probably done that much and more during a 'session' because redosing is so god damn compulsive when you're iming.

 

[psood0nym]

^plugged is almost indistinguishable from IM, to the point I would never bother IMing MXE. As an aside: if it's easier for you to stab a drug into your muscle with a syringe than it is to deposit it in your ass you have a serious psychological deficiency IMO.

 

[DroneLore]

I find them to be rather different, honestly.

Why must I be deficient because I am different? I hope you are not implying I am homophobic. I would find that most offensive.

 

[Confield]

^plugged is almost indistinguishable from IM, to the point I would never bother IMing MXE. As an aside: if it's easier for you to stab a drug into your muscle with a syringe than it is to deposit it in your ass you have a serious psychological deficiency IMO.

Keep in mind, some of us have also physiological deficiencies which might not make plugging seem particularly appealing Psychologically I'd have absolutely no problem with plugging, actually it sounds kind of fun, but without going into too much detail i'd rather leave my sensitive ass alone at this moment.

 

[IamMe90]

I find them to be rather different, honestly.

Why must I be deficient because I am different? I hope you are not implying I am homophobic. I would find that most offensive.

Maybe not homophobic, perhaps just uncomfortable with one's own body. seems to be pretty common among males for a variety of reasons.

 

[psood0nym]

I find them to be rather different, honestly.

Why must I be deficient because I am different? I hope you are not implying I am homophobic. I would find that most offensive.

My comment is on the assumption that IMing and plugged are substantially similar in terms of potency and rate of onset. For me, they are, and others have reported similar. I'm suspicious of the motivations of people who will stab a needle into themselves, doing damage to their tissue as well as exposing themselves to IMing associated infection risks, before they will put something in their ass is all. If all else is equal it's blatantly irrational to inject. The accusatory tone of my post isn't directed at you so much as it is at the throngs of people out there who are terrified of their own assholes and adopt ridiculously defensive attitudes about plugging because they somehow draw a connection between it and homosexuality.

Good luck with those hemorrhoids you strangely went out of your way to tell the world about indirectly Confield.

 

[Morkin]

without going into too much detail i'd rather leave my sensitive ass alone at this moment.

Too much detail bro.

Maybe not homophogic...

This is when you eat homos?

Dewds, the ass is not gay. It is an ass.

 

[TheAppleCore]

In making an effort to focus on the periphery of my vision I was making an effort to shift perception and observe the visual constructions of my brain rather than observe the dense aggregations of photons from the outer environment entering my cornea and causing highly defined reactions on my retina that result in standard optical perception of the environment. Attention is the "eye" referred to in my aural hallucination instructing me to "turn the eye within the eye" that first time I experienced the extraordinary visuals with MXE.

Awesome. So, is the point of light in the actual center of your vision, or off to the periphery, in the center of your conscious attention? Intuitively, I feel like it would work best when you're focusing your conscious attention on peripheral darkness, to the side of a central point of light (your brain is extrapolating the central light into the periphery).

I find them to be rather different, honestly.

Here's something I've noticed with MXE users. Because of the extremely variable nature of MXE trips in general, people experience substantially different effects from trip to trip, and incorrectly attribute the difference to external variables, rather than the intrinsic variability of MXE itself. So, people get all of these wacky delusional ideas about differences between routes of administration, and various "batches" of MXE, when they're all more or less the same.

 

[psood0nym]

Awesome. So, is the point of light in the actual center of your vision, or off to the periphery, in the center of your conscious attention? Intuitively, I feel like it would work best when you're focusing your conscious attention on peripheral darkness, to the side of a central point of light (your brain is extrapolating the central light into the periphery).

If, right now, you look off into your surroundings, at the exact center of your field of vision you will find your optical focal point. This center is where the curvature of your cornea is perpendicular to whatever object you are focused on in your surroundings. Your cornea focuses light from the environment on your retina, and what you perceive from the center of your retina is most representative of the light incoming from the environment. Outside of this center the environmental information, in the form of light (photons), is less defined. Because of this lack of definition, the brain must construct perceptual information (extrapolated from what it receives from the environment) that is not provided by the flow of light from the environment through the eyes. This extrapolated construction of incomplete information is what we are interested in focusing on when it comes to MXE visuals because it is what our brains are creating for us. MXE is influencing perception, not optical processing, and so by attending to the part of our vision that is most perceptually influenced rather than optically influenced we give ourselves the best chance to witness hallucinations.

 

[TheAppleCore]

^ Yeah, but in your particular experiment, how did you achieve this? Were you in complete darkness, or were you looking at something in particular in your environment?

 

[psood0nym]

^I referenced a post from 2011 describing the context in which I first experienced these visuals earlier in this thread. I was in bed, at night, looking at my other pillow. I don't think the particulars matter so much as the technique of attending outside of one's optical focal point. Such a state may not be attainable for those tolerant to dissociatives, I don't know for sure, but its extraordinary nature makes it seem like it should be attainable despite tolerance.