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The Big & Dandy Methoxetamine Thread-11th Dose-50 grams and a kidney later..

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Okay, so I've reached a point where...I realize...doing more of this substance is absolutely pointless and a waste.

I feel as though some receptor or some chemical in my brain is depleted so much so that I simply can not enjoy the high any more. I want to say it's the dopamine, because I redose...and redose, and nothing happens...it's just...inhaling material. It's pointless.

I need to stop now. I'm done. I got two grams, went through about 400 to 500mg in a weekend and a day or so, now I need to stop and recover since I have work tomorrow. This stuff makes my insomnia more prominent and potent and it encourages long days and nights. It's no good. I'm done for now.

Question:

Is it possible for dopamine receptors to never be returned back to normal? I want to return to baseline and let my body recover. My body's chemistry is way off due to this in take of substances. I wish to make it return to baseline. Say I take a few weeks off and just stick to Cannabis, will I be fine? I hope so. I want to continue using this substance in miniscule doses to aid in creativity and such, but not so much where it becomes a problem like it has become.
 
THCified said:
Some time ago i had some K and as i came back from the depths of a hole, i ingested 20mgs 4-AcO-DMT rectally and had one of the best drug experiences ever.

That said, after thinking about trying out the MXE/4-HO-MiPT-Combo, i had some MXE (30mgs/oral) with some 4-AcO-DMT (20mgs/oral) yesterday. Without the slightest exaggeration this was BY FAR the best thing i could've done. If you think MXE is awesome and somewhat addictive, don't dare to think about trying this combo!

I mean, holy fuckin' Jesus, this was so good, it's beyond what words can say. Had i died and never did this combo, i'd surely missed the holy Grail of psychedelic madness. Besides the awesome feeling of being wrapped in a warm blanket, feeling content and calm, the wall of euphoria that hit me was so strong, i literally got raped by happiness!

Best thing is, there was zero bodyload, muscle tremors or anything else. Nothing!

If one wants to try this one, i'd suggest take your dose of MXE and when it starts to kick in, take the 4-AcO-DMT and fasten your seatbelts! It's really interesting how you can distinguish the effects of each substance even though you're totally out of this world.

Duration: approx. 5hrs.
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What was the time for administering the MXE and 4 AcO DMT?
 
^re read paragraph 5. for me that means taking the psych about 30 minutes after the mxe.
i second the advice... pretty much always worked a charm for me.
 
J.Wallace said:
Okay, so I've reached a point where...I realize...doing more of this substance is absolutely pointless and a waste.

I feel as though some receptor or some chemical in my brain is depleted so much so that I simply can not enjoy the high any more. I want to say it's the dopamine, because I redose...and redose, and nothing happens...it's just...inhaling material. It's pointless.

I need to stop now. I'm done. I got two grams, went through about 400 to 500mg in a weekend and a day or so, now I need to stop and recover since I have work tomorrow. This stuff makes my insomnia more prominent and potent and it encourages long days and nights. It's no good. I'm done for now.

Question:

Is it possible for dopamine receptors to never be returned back to normal? I want to return to baseline and let my body recover. My body's chemistry is way off due to this in take of substances. I wish to make it return to baseline. Say I take a few weeks off and just stick to Cannabis, will I be fine? I hope so. I want to continue using this substance in miniscule doses to aid in creativity and such, but not so much where it becomes a problem like it has become.
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Oh man have we seen this quite a few times. Look dude, I doubt you can stop using ridiculously high doses of this stuff, let alone use it in "miniscule doses to aid in creativity." You need. To. Stop. You clearly are not someone who can use this drug casually, and you're deluding yourself if you think otherwise.
 
I massively abused this chemical awhile ago along with 3-meo-pcp, I was injecting it though and the overall high disappeared but the initial rush didn't. There was dissociation after the rush but it wasn't pleasurable anymore, abusing chemicals that increase dopamine, serotonin etc. levels in the brain is likely to cause your brain to down regulate it's own production of these neurotransmitters to compensate for not needing to while being bombarded with them from an exogenous source. This explanation is probably oversimplified and there could be other mechanisms at work but these things are usually mostly/completely recoverable. (I can't say anything for sure about long term abuse of this class of chemicals/this chemical but I can relate my own experience with it.)

You can't keep using the drug before recovery has taken place and not make this worse, so stop and let your brain recover. I went crazy with the IV usage of it for a couple months, don't let yourself get to that point. When I ran out and decided not to order it again it took a couple weeks to feel normal and the withdrawal felt kind of similar to opiate withdrawal (RLS, insomnia, anxiety) but not nearly as bad, what made it uncomfortable was the a motivational syndrome and feeling like everything was overwhelming/not being able to fully comprehend much of the situation at hand without coming up with very melodramatic scenarios about everything and struggling with simple logic. Kind of a long lasting foggy dissociation.

In my experience, it is fully recoverable but I can't comment on how long it takes to start to be enjoyable or if there is a "Point of No Return" although tolerance, from what I have read takes a long time to go down. Just leave it alone for a long while because if you keep abusing it then it will continue to be a fruitless experience.
 
Ligaturd said:
I massively abused this chemical awhile ago along with 3-meo-pcp, I was injecting it though and the overall high disappeared but the initial rush didn't. There was dissociation after the rush but it wasn't pleasurable anymore, abusing chemicals that increase dopamine, serotonin etc. levels in the brain is likely to cause your brain to down regulate it's own production of these neurotransmitters to compensate for not needing to while being bombarded with them from an exogenous source. This explanation is probably oversimplified and there could be other mechanisms at work but these things are usually mostly/completely recoverable. (I can't say anything for sure about long term abuse of this class of chemicals/this chemical but I can relate my own experience with it.)

You can't keep using the drug before recovery has taken place and not make this worse, so stop and let your brain recover. I went crazy with the IV usage of it for a couple months, don't let yourself get to that point. When I ran out and decided not to order it again it took a couple weeks to feel normal and the withdrawal felt kind of similar to opiate withdrawal (RLS, insomnia, anxiety) but not nearly as bad, what made it uncomfortable was the a motivational syndrome and feeling like everything was overwhelming/not being able to fully comprehend much of the situation at hand without coming up with very melodramatic scenarios about everything and struggling with simple logic. Kind of a long lasting foggy dissociation.

In my experience, it is fully recoverable but I can't comment on how long it takes to start to be enjoyable or if there is a "Point of No Return" although tolerance, from what I have read takes a long time to go down. Just leave it alone for a long while because if you keep abusing it then it will continue to be a fruitless experience.
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You know what, this post really opened my eyes. For the longest time, I've wanted to simply order this chemical and collect it. Not for personal use or distribution which I honestly have no interest in getting involved with. I want to simply collect as much of this as I can, I know one day it's going to be banned, so why not stock up on it and keep it for later uses? I'd much rather be doing that as oppose to basically wasting my money on something I'm not even enjoying anymore.
 
pontifex01 said:
Well you learn something new every day. Yes I was referring to the recent binding assay. It's possible dopamine affinity was overlooked as the affinity is much weaker than that at SERT and NMDA sites? (Complete conjecture, not a specialist in this field by a far cry).
The point is moot anyway when we're looking at situations in which there is extreme abuse of NMDA antagonists, particularly MXE. It's serious shit to be treated with respect.
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I wish i could be of more help. That paper i linked mentioned another study in which PCP was shown to have an affect on monoamine reuptake. Also, Ketamine had more activity at D2 than PCP so I'm guessing D2 agonism doesn't fully explain the mania/stimmy effects. of course (afiact) these studies are on rat brain receptors.
 
Anybody else notice a distinct change in experience regarding way of dosing? Snorting feels more stimulating, has a bit more edge to it, while sublingual feels more sedating, abit more psychedelic as well.
 
Well I'm done with MXE for a while. There's no point in doing it anymore, I literally get no effect from super high doses. My tolerance is just crazy and honestly I've probably destroyed whatever receptor was giving me the high. I went through a single gram I ordered in 2 nights, then thought maybe it was just a bad batch so ordered another gram. Almost went through the entire gram in a single night. I would keep plugging around 60-80mg every 10 minutes or so and didn't feel much of anything. I mean I was slightly messed up but it was like it just made me feel normal.

I thought ill just up the dose, tried plugging 120mg, still didn't feel much of anything. Tried the same dose about 15 minutes later. Nope. So yea no point for a while. I have been using MXE almost daily for over a year now. It wasn't daily for the first few months but it's probably been close to daily for about 8 months or so. Every night when I get home from work or class I will stay up for a few hours doing MXE while on the computer then just pass out.

It was fun. Shit is terribly addictive though. Haven't had any MXE in like 4 days or so. Not really missing it honestly.
 
I have been monitoring my intake, and I am veery close to a hole. What I have taken: 20 mg's every hour two times then I followed up with 30, so I'm now at 70 mg's MXE. I have done this sublingual instead of just snorting it, which I've done before in the same way. No delusions, much more control and clear thoughts. This leads me to believe that the way of taking this drug matters ALOT.
 
Hatrix maybe you should check the MXE addiction subthread, and prepare yourself for some kind of discontinuation syndrome just in case.
 
Solipsis said:
Hatrix maybe you should check the MXE addiction subthread, and prepare yourself for some kind of discontinuation syndrome just in case.
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I made a post in the addiction thread a month or two ago... So far I haven't had any problems. I'm keeping my fingers crossed. I did however experience withdrawals after going through 50mg of etizolam. So MXE seems to be free from any sort of withdrawal which is a very lucky thing.

I do expect some mood and attitude changes throughout the next couple months. Also hopefully gaining more interest back in activities and social events.
 
I definitley agree on that. What I like to do to prevent confusion and doubt is write the time and ammount of my doses on paper. When I want to redose, I can look at my notes and see how much is in my system. It has saved me alot of times actually.
 
had my first bad trip and panic attack after taking too much in one go(40mg oral). kinda reminds me of some dxm trips gone bad, the ones that are so terrifying that they put in perspective what drugs are capable of. was overdue for one of those

also, whatever "profound" thoughts i have on high doses don't seem to stick. either i forgot them or they seem really nonsensical in hindsight. and there's no coherense to anything. such a dumb but fun drug lol
 
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IME MXE can't really give you a bad trip UNLESS you worry about it's effects (dying etc..). Looking up information and tracking what you're taking and how much will avoid this for the most part. Also, the profound thoughts I get are usually fairly accurate if I manage to make them stick, I've gotten more valid insights and genuine emotion from this substance then mushrooms and acid combined..
 
Yes, "bad trips" tend to be panicked interpretations of unpleasant effects (head-aches, heart-racing, pains, etc.).

Can anyone suggest a good starting dose for sublingual? Any special preparations? Does this stuff taste bad? My MXE is in the mail :D
 
Depends on what you want to feel, for your first time I'd take 10-20 mg's sublingual and wait an hour or so to see how you feel.
 
dezz said:
IME MXE can't really give you a bad trip UNLESS you worry about it's effects (dying etc..). Looking up information and tracking what you're taking and how much will avoid this for the most part. Also, the profound thoughts I get are usually fairly accurate if I manage to make them stick, I've gotten more valid insights and genuine emotion from this substance then mushrooms and acid combined..
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This is false. Methoxetamine absolutely can give you a bad trip, no matter how prepared you may feel you are. Saying otherwise seems a little ridiculous in my opinion, as with any mind altering drug, anything can happen.
 
I'm not convinced low doses can carry the same gravitas as comparable doses of psychedelics but it is very possible to have a negative experience.
 
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