Olney's Lesions have not yet been proven or disproven to manifest in humans
The evidence is that ketamine and many other NMDA-receptor antagonists that have been tested in humans, cause an acute disturbance in neural circuitry that leads to psychotic manifestations. These same drugs cause the same disturbance in neural circuitry in rats and when we look at their brains we see evidence for physical neuronal injury. Since no one has looked at the brains of humans immediately after administering these drugs, we do not know whether the physical neuronal injury occurs.
—John Olney, Private correspondence
it, but after some reading i'm just a tiny bit more cautious from now on, even if i'd honestly like to take a dive into some MXE.I have mxe that's nearly 2 years old sitting in my computer case. Yes, that's where I hide my stash.
uh, is it still ok to use? i'm a bit scared. anyone know?
Stop hiding your drugs in your computer case. Heat is one of the number one causes of chemical degradation, especially with tryptamine and ergoloid chemicals. There are many far better places to choose.
Real talk.I have no negativity towards mxe, it's a delightfully fun drug, one of the most enjoyable around. My issue is with perceived benefits from it. My view is that dissociatives have more in common with opiates than with pyschedelics, psychologically speaking, and the risk/benefit of self-medication with them reflects this. Which is to say, it's pretty damn close to 'always a bad idea'.