Greetings.
So, I've been using MXE nearly every day for over 3 1/2 years. I took a couple breaks in the 30 day range, and a few shorter breaks, like maybe one day a week, and a 3 day break every 6 weeks or so, to try to keep tolerance manageable. I have tested with aspergers / autism spectrum disorder, but that could alternatively be something else like social anxiety disorder or whatever, the point is I have been self-medicating my sense of alienation, loneliness, etc., probably all my life, first with alcohol, then ecstasy, then psychedelics, and then disassociatives.
I wanted a more rock n' roll lifestyle, or maybe more Woodstock, and was on my way as a trained massage therapist, attending music festivals, Burning Man, tripping regularly, studying tantra and taoism and hula hooping, etc. But then my S.O. got pregnant and we hit a rough spot and it seemed that I needed to be more conservative to keep the family together. My trips grew fewer and fewer, and I got a white collar desk job, and between a new baby and the job, had very little time for anything. Ketamine seemed to be the answer, because it lasted so short, I could trip for an hour or so once or twice a week and that somehow made up for what I felt I had sacrificed to hold the family together. But after 6 months, I realized I was seriously fiending and addicted to the ketamine, and had some kidney pains, and read about that complication. So I quit cold turkey, and a month later found mxe, described as a related drug, so I tried it. The effects lasted longer but, on the other hand, were less conspicuous and, short of "holing," did not stop me from interacting with others, including family (though sometimes I overdid it and had to hide / avoid people because I felt my inebriation was too obvious).
I felt like I was having epiphanes and insightful thoughts on mxe, and maybe I was, but I am pretty sure mxe triggers whatever part of the brain feels like it is having a very profound "aha" moment, because a few times I overdid this and had intense "aha" moments about stuff that, later, I realized was bat-shit crazy. So I had started thinking this might be somewhat a cognitive enhancer, but now am more inclined to say it makes you feel smart, brilliant, etc., but does not objectively make you so.
I started mixing MXE with vicodin and tramadol after about a year. I had taken these one or two days a week instead of mxe, to help avoid the tolerance issue, but then just started combining them. I have read some warnings on tramadol and mxe, but never noticed anything major.
I will say that I noticed a lot of dryness in my eyes, and thirst, on mxe, and something about how it operates seems to affect this which makes sense since this would be somewhat related to the kidney function, which ketamine is known to mess with, and mxe is a ketamine analogue. I never got the kidney pain back using mxe, so I don't see that as an issue, but I did go to an eye exam recently after 3 years and the optometrist was shocked how much my vision had worsened in one eye (but not both). Apparently pretty unprecedented to have such a dramatic change at my age, with no obvious cause. My guess would be that the dryness from mxe was a significant factor.
My regular day I'd wake, go to work, and try to get so caught up in work that I did not think of MXE. If I succeeded, I'd dose at around 2pm. If I failed, my first dose would be around 10:30am. Here's an interesting twist: I felt a lot more f-d up on mxe at work on a smaller dose than at home. Like I would not even feel 20mg at home, would need twice that to have a small mxe buzz, but 20mg at work would have me feeling so trippy I was afraid to talk to coworkers for fear they'd notice. But I didn't talk to co-workers much, so it was not a big issue.
I'd re-dose in the afternoon, then at around 7pm because any later and I'd have trouble falling asleep at a normal hour, which would leave me more shambled the next day.
On weekends with family, I'd sometimes go all day without dosing, sometimes dose all day, but mostly take my first dose in the afternoon. The more stressful stuff I had to do, the more put-up that I felt, the sooner and more that I'd dose.
I've quit not for any obvious health issue, except I do think that anything you can do to salve yourself, can become an impediment to maturing and evolving in a healthy way. Like a crutch is great while your leg is in a cast, but if you keep using it afterwards, your body will get all contorted. Even when the cast first comes off and it hurts to use that leg, you need to use it for it to heal properly and if you decide to avoid that pain by using the crutch, you are going to have it worse in the long run. Like if I was unhappy because I was gaining weight because I could not find time to work out, I can take mxe and/or vicodin and feel okay with that, and do nothing to really change my circumstances. Basically, it let's me put up with stuff that, without it, I'd have to gather the resolve to change. And it's that gathering of resolve to changer things that is building character, maturing, evolving, etc. I realized i was putting that off, and the longer you put it off, the higher the price. I expect I'm going to have some tribulations making up for being somewhat numbed the last 3 1/2 years. I have probably made life choices the last 3 1/2 years under the constant MXE influence that I would not have made sober, so I find myself in a life and situation that is not really "me."
Which is another issue, maybe the main issue. On MXE, I stopped being myself, my true self, and instead I was a variation of myself. But not always the same variation. Like Dr. Heckell and Mr. Variable. Sometimes I was really into positive, healthy stuff, ready to throw out all the junk food. The next day I'd be rationalizing why none of that stuff mattered. I'd periodically think about what i wanted for my "dream job" if I were blue-skying my future, and it was not always the same, depended on what side of myself the mxe brought out. So I could not trust ANY of the answers as being my truest answer. Basically, it's hard to find yourself when you are always wearing a mask.
At one time, I thought of the way the spirit evolves through life as sort of like building a tower, and you need a strong foundation. Without that, the tower collapses or you just get stuck not able to go higher. Well, even if you get knocked down, you can start over, in some ways that's healthier than being stuck and not moving at all. But whatever you are building, it requires constancy to go up. When you are "under the influence" you are not really yourself, and you are no longer building upwards, but sideways. I feel like I'm 3 1/2 years behind in personal growth, maturation, etc., due to my near daily usage.
In conclusion, I'd just warn that the addiction potential is huge not necessarily because it feels so good, but because it seems so harmless. It's really hard to have a bad trip (though half my M-holes were nighmarish, only did that a few times, do not recommend holing on this), at lower doses it made me feel like I was gone, replaced by another incarnation of myself. So if I had work to do that I didn't want to do, I'd take some MXE and it would be that new incarnation that would have to deal with it. Sometimes I lucked out and got a really industrious incarnation who loved to work and organize and get stuff done. Sometimes I got an incarnation that said "to hell with work and chores, let's have fun" and then I was left with a bigger mess to clean when I sobered up.
Well, those are some of my thoughts on MXE. I still miss it. I'd like to have some on hand to enjoy on occasion, but I'm pretty sure I'd just go back to a daily habit if that happened. I've been off it for about 2 weeks. Also, have been off the tramadol for a few months because I felt that not really doing me any good. Now i've got a short supply of vicodin, (and lots of xanax and weed) to sort of scale down off the vicodin. Then I'll just be a pot-smoker who sometimes takes xanax for sleep or whatever.
Oh, one last thing: Having the MXE around to do meant I did not do any other psychedelic or empathogen, or hardly ever. Has definitely been over a year. As much as a have bashed inebriation and altered mental states, I think as a rare experience they can help clear out the cobwebs, or jump start your soul, or whatever. MXE kind of stopped me from that. My thought now is that if I can ween myself back to just a normal sober person who smokes some week and such, then I will be in a position to occasionally enjoy the experiences that never really posed the same kind of addiction risk, like shrooming at a forest party, or doing acid at a music festival, or whatever. I think the occasional heavy trip may be much healthier than what I was doing, which was like being in a near-constant state of slight trippiness.
~psychoblast~