The Big & Dandy Methoxetamine (MXE) Thread - Chapter 14

[mindseye888]

Sorry people, was in mxe euphoria land last night and had to share my little mind numbed thought.

 

[vortech]

Floaty and numb...I'm Flumbed...I love this stuff
Sorry people, was in mxe euphoria land last night and had to share my little mind numbed thought.

I love the word play and creative novelty that MXE inspires through that kinda daydreaming-loose-association-brainstorming-abstract-concepts state of mind.

 

[zn13bt]

You should really read VALIS by Philip K. Dick. He basically had the same experience and wrote a book about it. He was downloaded all sorts of information, ancient languages and esoteric knowledge and such, through the form of a pink laser beam that shot into his head. The book is fiction but highly inspired by his real episode.

Haven't gotten to that one yet...I've read Flow My Tears, the Policeman Said, The Man in the High Castle, Ubik, The Unteleported Man, The Three Stigmata of Palmer Eldritch, Martian Time-Slip and Time out of Joint. And I've seen Blade Runner, of course.

 

[heerutosen]

Holy shit! Did something very irresponsible but it turned out to be an amazing time.

First time MXE with friends: 10:00 am 75mg oral 11:00 am 25mg oral. Untill 18:00 pm only sedation and extreme nausea. Couldn't walk, music was not enhanced no visuals just sedated and catatonic at points with intervalls of rushing to the bathroom to puke.

Then i was advised to snort on a dutch forum. Before throwing the bag away i decided to snort 20-25mg at 20:00pm (first time snorting anything) something was defenitely happening now. proceeded to snort 3 more bumps.
Unable to move in my bed i had the most intense experience of my life.

I was sinking and floating and rising up going in circles etc (like the inside of a lavalamp) and after mushroom and 2cb like CEV's i eventually could see clearly through my eyelids. I was in a white room and other places after. At one point i was sitting in a chair like in a courtroom across from two people not saying a word and then i blasted off into another space and the music was telling me stories. But i saw the story before the vocals in the music told it.

In moments where i was a bit lucid i yelled for my roommate to bring me a bucket and some sugar water with salt. I was feeling very dehydrated and had to puke multiple times. Unable to open my eyes or walk thankfully i was given water and crackers(which i could not eat) and a bucket for puking (about 3 more times during the trip)

I think everything lasted about 6 hours, with a 2 hour peak which felt like an eternity. I can't remember everything, but there were times i thought i was going to die, but i wasn't scared at all and somehow it didn't matter.
I also knew this wasn't a dose i could OD on after reading other reports. Was what i experienced an Mhole?

Thanks for reading and im sorry about possible errors in grammar and spelling. Still a bit out of it.

 

[stereo mic]

Holy shit. MXE and Oxy is the best painkiller ever.

60mg of MXE and 10mg of Oxy snorted together. I can do heavy weights again. I have medical issues and thought that doing heavy weights was out the window. Not now.

 

[psood0nym]

Holy shit! Did something very irresponsible but it turned out to be an amazing time.

First time MXE with friends: 10:00 am 75mg oral 11:00 am 25mg oral. Untill 18:00 pm only sedation and extreme nausea. Couldn't walk, music was not enhanced no visuals just sedated and catatonic at points with intervalls of rushing to the bathroom to puke.

Then i was advised to snort on a dutch forum. Before throwing the bag away i decided to snort 20-25mg at 20:00pm (first time snorting anything) something was defenitely happening now. proceeded to snort 3 more bumps.
Unable to move in my bed i had the most intense experience of my life.

I was sinking and floating and rising up going in circles etc (like the inside of a lavalamp) and after mushroom and 2cb like CEV's i eventually could see clearly through my eyelids. I was in a white room and other places after. At one point i was sitting in a chair like in a courtroom across from two people not saying a word and then i blasted off into another space and the music was telling me stories. But i saw the story before the vocals in the music told it.

In moments where i was a bit lucid i yelled for my roommate to bring me a bucket and some sugar water with salt. I was feeling very dehydrated and had to puke multiple times. Unable to open my eyes or walk thankfully i was given water and crackers(which i could not eat) and a bucket for puking (about 3 more times during the trip)

I think everything lasted about 6 hours, with a 2 hour peak which felt like an eternity. I can't remember everything, but there were times i thought i was going to die, but i wasn't scared at all and somehow it didn't matter.
I also knew this wasn't a dose i could OD on after reading other reports. Was what i experienced an Mhole?

Thanks for reading and im sorry about possible errors in grammar and spelling. Still a bit out of it.

Yeah that's a dissociative "hole" experience alright. I'm not sure how much you were moving around during the onset, but that's often a factor in developing dissociative nausea, particularly with ketamine. Swallowing it might have also contributed, though nausea isn't very common by any route of administration to my knowledge. By some accounts snorting is even less potent than oral. Plugging is about twice as potent as either of those.

There are a couple recent threads that deal with aspects of your trip if you're interested, both focused on MXE.

Seeing through your eyelids (afterimages) and "flying": Sensations of highly dynamic motion/flight with coordinated visuals on dissociatives?

Interactive mind music: [MXE] Making music in your brains

Holy shit. MXE and Oxy is the best painkiller ever.

60mg of MXE and 10mg of Oxy snorted together. I can do heavy weights again. I have medical issues and thought that doing heavy weights was out the window. Not now.

Heh, your post reminds me of those kids who have that disease where they don't perceive pain and have had hundreds of broken bones because of it. I wouldn't be too enthusiastic about heavy lifting on drugs, or about having to take oxy and MXE to workout how you like.

 

[StickyChron]

I was away from BL (and drugs in general) for a few years now. Has anyone found that the quality of MXE has gone down since the days of the "official vendors" and all that bullshit?

If I were to find some, what color/consistency are people having the best luck with lately?

 

[heerutosen]

Yeah that's a dissociative "hole" experience alright. I'm not sure how much you were moving around during the onset, but that's often a factor in developing dissociative nausea, particularly with ketamine. Swallowing it might have also contributed, though nausea isn't very common by any route of administration to my knowledge. By some accounts snorting is even less potent than oral. Plugging is about twice as potent as either of those.

There are a couple recent threads that deal with aspects of your trip if you're interested, both focused on MXE.

Seeing through your eyelids (afterimages) and "flying": Sensations of highly dynamic motion/flight with coordinated visuals on dissociatives?

Interactive mind music: [MXE] Making music in your brains

Awesome! Thanks

 

[FlawedByDesign]

I was away from BL (and drugs in general) for a few years now. Has anyone found that the quality of MXE has gone down since the days of the "official vendors" and all that bullshit?

If I were to find some, what color/consistency are people having the best luck with lately?

Quality has been good all year long excluding this very last batch. The good stuff has a salt like consistencey with alot of decent sized shards to be found. It has no burn to speak of and doesn't have much of a taste. This last batch however, is more powdery with no shards or crystals and has a slight sting when insufflated. It more or less gets the job done although that fact that it burns even a little bit is a huge red flag. (Thank goodness I stored a couple grams of the good batch when I was taking a tolerance break%))

 

[I B Profane]

I have 5g of this stuff coming sometime this week.

...so don't be surprised if, later this week, I'm in this thread incoherently babbling about synchronicities and conspiracy theories and philosophy and a whole bunch of other unintelligible garbled gibberish...8(

 

[GolemGolem]

I was away from BL (and drugs in general) for a few years now. Has anyone found that the quality of MXE has gone down since the days of the "official vendors" and all that bullshit?

If I were to find some, what color/consistency are people having the best luck with lately?

Have not had even a meh batch for quite a while. The white, dense, crystaline stuff that's going around is the tits. Bullshit it was, back in 11' the best batch I ever had looked like the new stuff.

 

[isthisincognito]

I came across this, published recently - Three months of methoxetamine administration is associated with significant bladder and renal toxicity in mice

Abstract

CONTEXT: Methoxetamine is a ketamine analogue that has recently emerged as a novel psychoactive substance. Chronic ketamine use is associated with significant bladder and renal toxicity. Methoxetamine has been marketed as "bladder friendly", but there is no data to be able to substantiate this claim.

OBJECTIVE: To characterise the patterns of bladder and renal toxicity associated with 3 months of methoxetamine administration in an animal model.

MATERIALS AND METHODS:Two-month-old Institute of Cancer Research mice were administered 30 mg/kg methoxetamine intraperitoneally (n = 5) or saline (n = 3 control) for 3 months. The animals were then sacrificed and histological examination, immuno-cytochemistry using polyclonal anti-CD4 antibodies and sirius-red staining for collagen were performed.

RESULTS: The kidneys of methoxetamine-treated animals showed inflammatory cell infiltration, tubular cell necrosis and glomerular damage (1.9 ± 0.3% shrunken glomeruli in control, 9.8 ± 0.8% in methoxetamine-treated mice (p < 0.0001); 2.9 ± 0.3% tubular cell degeneration in control, 20.4 ± 1.1% in methoxetamine-treated mice (p < 0.0001)). There was a greater density of mononuclear cells in the bladder lamina propria and submucosa in methoxetamine-treated mice (43.0 ± 2.1 per 250 × 250 μm) than controls (7.1 ± 1.2 per 250 × 250 μm), p < 0.001. CD4-positive staining was seen in the bladder submucosa and lamina propria of all methoxetamine-treated mice and muscle-layer of two methoxetamine-treated mice; these changes were not seen in the control mice. There was an increase in sirius-red collagen in the bladder sub-mucosa and muscle-layer in the methoxetamine-treated mice compared with control mice.

DISCUSSION: This study has shown that 3 months of daily 30 mg/kg intra-peritoneal methoxetamine results in significant bladder and renal toxicity in mice. Changes in the bladder included inflammatory changes with subsequent fibrosis and changes in the kidney were seen at both a tubular and glomerular level. These changes are similar to those seen in comparable animal models of chronic ketamine administration. Further work is required to determine the time course of the onset of these effects and whether the effects are reversible with methoxetamine cessation.

 

[Bone14]

30mg/kg? So that would be the same as if I took 2,7g IM everyday?

This study is useless.

 

[isthisincognito]

^ For someone my size, it's 1500mg a day.

Back in the peak of my use, I probably went through 3.5 - 5g a week at my worst - albeit I didn't IM anything back then.

I've seen a few posts in the Methoxetamine Addiction Subthread of people doing a gram a day. It's not such a stretch.

Although I have no idea how mice translates into human, and also the consequence of the reported damage, or its reversibility.

 

[I B Profane]

5g of this stuff is currently sitting in my friends mailbox...only problem is, I have to wait until 11pm till I'll be able to access it. I have work at 10 am tomorrow morning, but I don't care, I'm taking some tonight.

I probly wont go for a full m-hole dose since I don't wanna be wonky at work tomorrow, but I definitely would like to trip out. I haven't used this stuff since last September, even though it is possibly my favorite psychedelic (or dissociative) next to dmt.

Not much to add other than I'm really stoked and will report back with results :D :D :D :D

 

[vortech]

There was a discussion of the mice study in this thread a few pages back. The large amounts used (1.5-3 grams a day human equivalent depending on your weight) does make it harder to glean practical value out of the data. However, as isthisincognito just mentioned, it's actually not all that much of a stretch for the hardest chronic abusers, so we can at least confirm it is harmful at the extreme end.

One other thing though- isn't 3 months a considerable percentage of a mouse's lifetime? If 3 months is 1/4 of an entire mouse lifetime, if we were to translate this data to humans, is that the rough equivalent of taking MXE every day for 20 years? Or does it not work like that?

 

[zzz101]

5g of this stuff is currently sitting in my friends mailbox...only problem is, I have to wait until 11pm till I'll be able to access it. I have work at 10 am tomorrow morning, but I don't care, I'm taking some tonight.

I probly wont go for a full m-hole dose since I don't wanna be wonky at work tomorrow, but I definitely would like to trip out. I haven't used this stuff since last September, even though it is possibly my favorite psychedelic (or dissociative) next to dmt.

Not much to add other than I'm really stoked and will report back with results :D :D :D :D

yeah would be interested to see how you go.

do you prefer oral dose?


i think an old batch of mXe was so good, the rest from then have missed that awesomeness, but still ok. i can tell the difference though.

 

[I B Profane]

yeah would be interested to see how you go.

do you prefer oral dose?


i think an old batch of mXe was so good, the rest from then have missed that awesomeness, but still ok. i can tell the difference though.

Ill keep ya posted I usually dose either sublingually or intranasally. I might do a bit of both tonight? We'll see where the night takes us. I'm not sure if I'd be able to notice a difference in batch quality, having not used mxe for almost a full year and having zero dissociative tolerance atm

 

[zzz101]

aight cool. yeah just remember ur low tolerance.

when the legal mxe error was around, that mxe had more of a rush to it ime.

good thing with mXe, it is a drug where dosing more than once is better. start low and work ur way up and get where you want to.

oral dosing is king i think. most similar to subly. (other RoAs have their strengths though) if you're doing more than 10mg at a time, oral just takes ages to kick in, but worth.

but if you have work the next day, sometimes oral dosing takes too long.

 

[I B Profane]

^yeah, I have work early tomorrow so I don't wanna push it too far...I figure I have work at 10 am, I gotta leave my place and start walking by 930 am. If I dose the mxe at 11pm (35 minutes!!!!) then that gives me until, say, 5 am to be mexxed out as possible before I decide to eat a bunch of etizolams and call it a night. 4 hours of sleep is better than no sleep, lol.

I will definitely try oral dosing when I have the day off. As for tonight I think I may snort it...I'm aware faster ROAs exist, but have never used needles before, nor have I plugged anything. Not that im inherently against either of those things, just haven't experienced them yet.

I plan on taking it nice and slow, starting with a 5-10mg allergy test (to make sure I have the real deal) and from there on do ~25mg bumps until I get to where I need to be. Depending on quality of the batch I expect to go through 50-100mg tonight, but we'll see. I definitely agree with you that the magic of mxe lies in slow, controlled steady dosing, rather than one big dose all at once. The latter is a bit too disorienting.

Will report back from space