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The Big & Dandy Medication/Supplement Interaction Thread

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5HTP is actually classed as a nootropic or can be. So can acid and SSRI's I believe....
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Most serotonergic compounds have neurotrophic effects as they trigger the release of BDNF in cortical neurons. LSD is probably the most potent nootropic known to man, at least in prefrontal cortical neurons. The SSRIs are less effective in causing neurotrophin release in cortical neurons, but help catalyze neurogenesis in the hippocampus and I wouldn't be surprised if 5-HTP had this same effect.

I've done the hydergine/LSD combo a number of times and I didn't notice a whole lot of potentiation of visuals, but the trip felt 'crisper' and more lucid.
 
f&b and thisusername

could you elaboate on how 5htp altered your experiences with those compounds? I take 5htp daily, and have combined it with tryptamines and had no adverse effect.
 
swilow said:
5HTP is actually classed as a nootropic or can be. So can acid and SSRI's I believe....
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5-HTP, LSD, and SSRI's are not nootropics. Nootropics improve and protect cognition.

SSRI's and LSD should never be used by healthy adults.
 
The Wizard said:
I'm the type of person who regularly uses a number of health supplements, vitamins, amino acids, smart drugs, adaptogenic and immuno boosting herbs to better my mental and physical health and I'm also the sort who likes to partake in psychedelics with some frequency. One area that I've not found much information about is what possible interactions psychedelics can have with these natural and synthetic health drugs.

I'm going to list a number of supplements, nootropics (aka smart drugs) and herbs and ask you bluelighters whether you've had experiences using them while tripping. If so, what dosage of the health drug were you using, what psychedelic did you combine it with (and at what dosage), and was the interaction positive or negative (or perhaps you didn't notice an interaction) in your opinion?

The health drugs I'm most wondering about are: Piracetam (or other Racetams), Hydergine, DMAE (or Centrophenoxine), DL-Phenylalanine (or L-Tyrosine), SAM-e, Sulbutiamine, Modafinil (aka Provigil), Vinpocetine, Lecithin, Rhodiola, Phenibut, L-Theanine, Taurine, Niacinamide, Vitamin C, Vitamin B12, CoQ10 (or Idebenone), Calamus (aka Sweet Flag), Ginseng, Eleuthero (aka Siberian Ginseng), Maca, Catuaba, Chocamine, Cocoa, Yerba Mate, Bacopa, Ashwagandha, Coca, Kava, Sceletium (aka Kanna), Blue Lilly, Kratom, Selegiline (aka Deprenyl), Bupropion (aka Wellbutrin), Moclobemide, Tranylcypromine, Amineptine, Tianeptine, Neurontin, Melatonin, 5-HTP.

If there's any health drugs I left off the list that you've combined with psychedelics and had noteworthy experiences feel free to comment on those as well.

Of the above list I've used the following at various times with psychedelics: Piracetam, Hydergine, DMAE, DL-Phenylalanine, SAM-e, Lecithin, Rhodiola, Taurine, Niacinamide, Vitamin C, Vitamin B12, CoQ10, Catuaba, Selegiline, Buproprion, Melatonin, 5-HTP. The majority of times I used any of these health drugs with a psychedelic the interaction seemed either positive or so subtle that it wasn't noticeable. I'm yet to have a time that I've combined a health drug and psychedelic that seemed particularly negative.

One last thing- I'm not trying to recommend you guys go out and combine any of these health drugs with psychedelics as exploring such uncharted territory can obviously be very risky and a double edged sword if one doesn't know what they're doing. My approach when combining health drugs and psychedelics has been to try to be extremely cautious and scientific and listen carefully to how my mind and body are reacting. I've a feeling adaptogens and smart drugs for the most part have the most potential for positive interaction with certain psychedelics if used properly.

My most recent experiment combining health drugs and psychedelics was Friday night when I combined 21 Hawaiian Baby Woodrose seeds (ground finely and mixed into a jar of cold water, peppermint extract, peppermint tea, everclear and lemon juice), some Piracetam, Rhodiola (3% Rosavin powder), Vitamin C, DXM (in the form of one bottle of Zicam Max Cough Mist which is what around 390 mg?) and beer ( 5 or so Miller Lites). The DXM and beer I didn't take until I was coming down from the HBW (abbreviation for Hawaiian Baby Woodrose). The trip was very clear, euphoric and enjoyable for the most part with no harsh comedown at all and an oh so wonderful after glow Saturday morning.

I very much appreciate if any of you can give me feedback on your past health drug/psychedelic combinations :)

Oh, and for the record the psychedelics I've used with health drugs in the past are: HBW, MG (Morning Glory), blotter, MDxx, DXM, and 2CE. I'd love to in the future explore Mescaline containing cacti, Amanita muscaria, Salvia divinorum, DMT and Ayahuasca combined with health drugs.

I've found the right health drugs can really help to cut down on the potential side effects and dangers of certain psychedelics. For example, HBW can sometimes cause a pretty unpleasant feeling of vasoconstriction (unpleasantly tight, twitchy muscles being a common symptom) and I find eating vasodilating supplements like L-Arginine, CoQ10 and Taurine can really help cut down on this.
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Many people seem to find Phenylethylamine at 1-2 grams taken during an LSD "trip" can "enhance" the effect.
 
I have found that the 'acetams positively modulate serotonergic psychedelic action.
 
LSD and zoloft

I'm currently taking zoloft 100mg a day and I have been told that it reduces the effects of LSD and MDMA. How long would I need to be off my meds for if I wanted to experience the full effects of either LSD or MDMA? Will the LSD or MDMA have any effect at all if I take them while still on the zoloft?
 
The MDMA will be of no use to you--sertraline, fluoxetine and citalopram tend to completely inhibit the effects of the serotonergic amphetamines (venlafaxine does as well, but not quite as completely). The LSD will be fine, but your tolerance for the visual psychedelic effects will likely be higher than most other people, so you will need to take a comparatively higher dose of LSD. Thankfully, LSD is extraordinarily safe from a physical standpoint and has a very high therapeutic index. So, just skip the MDMA (I've tried MDMA once--you're not missing much, it's not a psychedelic) and go for the L.
 
^ Not missing much? MDMA is fantastic! Maybe you need to find some Molly or something. ;)

To the OP: MDMA works by binding to serotonin transporters and reversing them; Zoloft works by binding to serotonin transporters and preventing them from working. So SSRIs will block the effects of MDMA.

As for LSD, you will need more of it to get the same effects you would otherwise. However, seeing as your on the anti-D's for a reason maybe you should wait until your finished with them before starting to use again.

As for how long to wait; depends how long you've been on them. It can range from a month to six months before you feel the full effects of MDMA again I've heard from some BL'ers; waiting a few months after I finished Zoloft allowed to me to roll fine.
 
^^It was molly, confirmed (or at least reagent tested) MDMA, not some random pressie. But I think MDMA is more of an interpersonal relationship or 'couples' drug, alas I have no use for it and therefore didn't derive any therapeutic benefit from it. It is also important to keep in mind that I have been on venlafaxine for years, so I cannot possibly say that I had a "complete" MDMA experience--I doubt I am capable of having a full MDMA experience. Hence, my trial does not represent the typical response. Indeed, most people seem to like MDMA; I just found it to be like "silly speed" and greatly prefer the focusing, attentional and brain "de-fogging" pro-cognitive properties of regular dextroamphetamine.

Psychedelics, on the other hand, (particularly LSD) have helped me actually appreciate life--and even enjoy things--after more than a decade of anhedonia, apathy and utter nihilism.

Whoa, I just kind of kept talking there, didn't I? Sorry to get off-topic--this thread isn't about whether or not I like molly.
 
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I was never on zoloft, but even low doses (7.5mg/day) of paroxetine (paxil) completely blocked all effects not just of MDMA but also of LSD. It also completely negated all effects from 1500+ mg mescaline other than some stimulation and mild auditory hallucinations. So I wouldn't assume that just upping the LSD dose will yield noticeable effects. On the other hand, I suppose there's no harm in trying...
 
Interesting. As I said, I've on venlafaxine (Effexor) at a low-moderate dose and psychedelics still exert quite glorious effects on me, particularly LSD. Perhaps different SSRIs have different effects in this sense.
 
Mushrooms and Cymbalta

someone i met takes 30 mg of cymbalta everyday and I was wondering has anyone tried mushrooms while using cymbalta. Now I know that there are many guides on SSRI use and psychedelics, however cymbalta or Duloxetine, is not an SSRI, but a serotonin-norepinephrine reuptake inhibitor (SNRI). So since it works on both Serotinin and norepinephrine is there going to be something else occuring. Basically I want to know if it is worth taking the shrooms.
 
prozac and acid

so i took 1 prozac last night to help with an mdma crash. how long will i have to wait to do acid. id like to do some on saturday
 
Do you take prozac regularly, or was this just a one time thing? It might not be wise to mix LSD and prozac if you are on a regular regiment (can cause seizures, and will most definitely dull the trip), but if it was a one off then you should be fine to dose on Saturday. Just don't take anymore.
 
Mushrooms and Omeprazole

Well i munched a compressed pill of shrooms the other day. I was expecting a capsule stuffed with ground up shrooms but my dealer swore this to be legit.
It scaled out to 1.1 grams.

Now the trip was everything you would expect from a mushroom trip after reading up on it at Erowid, except the fact that they took 3 and a half hours to kick in.

My theory is that the Omeprazole that I take daily to lower stomach acid (Because of a undiagnosed GI problem) resulted in the capsule talking longer than normal to break down.

Is this possilbe? Has anyone encountered these compressed shrooms in the past? Anywhere I can get more information on them?

THIS IS NOT A "WHAT DID I EAT THREAD"

Thanks!
 
I inject Humira SC every two weeks for my Crohn's Disease. I wanted to try oral DMT but wanted to make sure the maoi won't have any bad reactions to the Humira. I wouldn't think so as it works on TNF and white blood cells and has nothing to do with serotonin ot brain chemistry. I just wanted to make sure.
 
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