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The Big & Dandy LSB (Lysergic Acid 2-Butyl Amide) Thread

red22 said:
Imagine 1B-LSB?
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It would metabolize into normal LSD but just be weaker by weight. 1-Subs only exist to get around chemical bans as far as I'm aware.

I'd love to see what 1-(2-Methoxybenzyl)-LSD would be like to see if the 2-substituted benzyl functional group seen in things like NBOMes and Clobenzorex has any effect on lysergamides. Might need to be hung off of the R6 or R7 positions instead of R1 though, on LSD, idk. That's my two cents on a more interesting way to squeeze butylamine into LSD, it would just be a profound pain in the ass to make.

I feel like tons of people without chem knowledge think that they can learn to break down the names of drugs like you do a language you're learning to understand it better. The amount of people I've met who think that 4-Fluoromethylphenidate is an analog of 4-Fluorophenibut is fucking insane, I wish more people just cared about and researched chem in general I suppose. It's a really beautiful and fascinating field, but so many people have so little faith in their own intelligence that they neglect even attempting to understand something as beautiful as chemistry.

</rant>
 
red22 said:
Imagine 1B-LSB?
Click to expand...
If 1p-LSD is legal in your area than LSB probably is too. They are both LSD analogs so no need to add a 1p to it

I'm interested in LSB, its too bad half the focus of RC market so far has been on adding 1p or 1cp etc to LSD to make it legal instead of looking into some some possibly interesting lysergamides that are actually unique
 
Viraldrome said:
If 1p-LSD is legal in your area than LSB probably is too. They are both LSD analogs so no need to add a 1p to it

I'm interested in LSB, its too bad half the focus of RC market so far has been on adding 1p or 1cp etc to LSD to make it legal instead of looking into some some possibly interesting lysergamides that are actually unique
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I suspect it's a result of the fact that the aren't any other lysergamides I can think of that are comparably potent and high yielding. Yeah you going sell LADs or MiPLA but you're using way more source material, so now you need to mark up the price on a drug people are already unfamiliar with and sketched out by. I get why LSD naturally won the capitalistic Darwinian game in this way.
 
red22 said:
Would a dibutylamide be possible?
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Realistically if somebody attempted to make this, there would probably be a high percentage of dibutyl groups and a small amount of partially reacted monobutyl groups. That's my guess as far as this goes, inferring from the alkylation reductions of simpler tryptamines. With most acid nowadays being peptide coupled though (thanks Casey) I'm not positive if similar impurities would be present, I've never used a peptide coupler and then tried to fraction out the product. Not yet at least.
 
Would it be an oversimplification to assume that lysergic acid dibutylamide would be practically the same as LSD and that lysergic acid butylamide would be essentially the same as LAE-32?

“A substance very closely related to LSD, the monoethylamide of lysergic acid (LAE-32), in which an ethyl group is replaced by a hydrogen atom on the diethylamide residue of LSD, proved to be some ten times less psychoactive than LSD. The hallucinogenic effect is also qualitatively different: it is characterized by a narcotic component. This narcotic effect is yet more pronounced in lysergic acid amide (LA-111), in which both ethyl groups of LSD are displaced by hydrogen atoms. These effects, which I established in comparative self-experiments with LA-111 and LAE-32, were corroborated by subsequent clinical investigations.”

Albert Hofmann. LSD: My Problem Child (1979), 3. Chemical Modifications of LSD

“On the basis of the observations, the investigators considered LAE as a new kind of "sedative"; a sedative which in its effect is neither related to the group of hypnotica and narcotica of the barbituric or morphine type, nor to the group of the sympathico- or parasympathicolytic chemicals.”

Project MKULTRA, Subproject 8. Memorandum for the Record. 9 June 1953

More info about LAE-32:

https://nervewing.blogspot.com/2020/05/obscure-and-unknown-lae-32.html


Viraldrome said:
If 1p-LSD is legal in your area than LSB probably is too. They are both LSD analogs so no need to add a 1p to it
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However, 1P-LSD was observed to be more stable than ALD-52 due to steric hindrance because of the propanoyl group.

Stability studies of ALD-52 and its homologue 1P-LSD. Zhang SH, Tang ASY, Chin RSL, Goh JY, Ong MC, Lim WJL, Yap ATW, So CW. J Forensic Sci. 2023 May;68(3):1009-1019. doi: 10.1111/1556-4029.15224
 
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red22 said:
Would a dibutylamide be possible?
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Just looked it up on PubChem and found that it's been made:

pubchem.ncbi.nlm.nih.gov

Lysergic acid dibutylamide

Lysergic acid dibutylamide | C24H33N3O | CID 92260373 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
pubchem.ncbi.nlm.nih.gov pubchem.ncbi.nlm.nih.gov


It's listed on the left:



Ergot Alkaloids and Related Compounds. Berde, B., Schild, H.O. (eds). Handbook of Experimental Pharmacology / Handbuch der experimentellen Pharmakologie, vol 49. 1978. Springer, Berlin, Heidelberg. DOI: 10.1007/978-3-642-66775-6_2 (2. Chemical Background. Rutschmann, J., Stadler, P.A. 6. Modifications of the Carboxylic Acid Function of d-Lysergic Acid, p. 47)
 
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This substance actually looks wild. See how it compares to LSD:


Lysergic acid dibutylamide (LBB-66)

Lysergic acid diethylamide (LSD-25)
 
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perpetualdawn said:
There are almost no reports on this substance. I noticed that a Canadian chemist that's been around for a long time now is stocking it but the minimum quantity is quite high, and I presume it's available in a powder form, which could be tricky to handle given the potency. Hopefully someone springs for it and shares some reports in the near future.
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Finally figured who you are talking about, the mysterious aMT source. Im thinking about buying the lsb. Its risky i may not like it, and the testing service wont be able to confirm its really LSB. And its a lot of money. But I want try every lysergamide. So far only LSZ was only let down

Never heard of

LSD-25-Pyrrolidate (N-pyrrolidinyl Lysergamide)

L3A (N-3-amyl Lysergamide)​

L2A (N-2-amyl Lysergamide)​

Are these even real??
 
Viraldrome said:
Finally figured who you are talking about, the mysterious aMT source. Im thinking about buying the lsb. Its risky i may not like it, and the testing service wont be able to confirm its really LSB. And its a lot of money. But I want try every lysergamide. So far only LSZ was only let down

Never heard of

LSD-25-Pyrrolidate (N-pyrrolidinyl Lysergamide)

L3A (N-3-amyl Lysergamide)​

L2A (N-2-amyl Lysergamide)​

Are these even real??
Click to expand...
I'm noticing also LAMPA listed, and a bunch of other lysergamides that I don't know much/anything about, not even sure if some of these are precursors or what. Really inteteresting.

@red22 Personally I didn't find LSZ to be a let down. I tried it once or twice - it seemed like it had nothing new to offer compared to LSD, which I suppose could be disappointing, but it didn't seem like there was anything wrong with it. I'd like to try it again to check.
 
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perpetualdawn said:
I'm noticing also LAMPA listed, and a bunch of other lysergamides that I don't know much/anything about, not even sure if some of these are precursors or what. Really inteteresting.

@red22 Personally I didn't find LSZ to be a let down. I tried it once or twice - it seemed like it had nothing new to offer compared to LSD, which I suppose could be disappointing, but it didn't seem like there was anything wrong with it. I'd like to try it again to check.
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that source has an instagram account by the same name of the company and they post updates on their syntheses regularity. It’s pretty interesting honestly, i’d give them a follow. they also respond to comments and dm’s if got have any questions or any requests for compounds for them to synthesize
 
I take that back. A message from them:

We have Methylergometrine that has a hydroxy and also LSB, along with LDsB. We can make what you stated possibly, but we have a couple more we want to make, including the; N-piperidinyl Lysergamide, N-ethyl Lysergamide and N-ethyl-N-propyl Lysergamide and maybe even the 2,2,2-trifluoroethyl Lysergamide (we can try this one too)
 
red22 said:
Why was it a let down? I heard it has a "body load" issue?
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It was all body, i wont call it load, it "felt" like acid but without visuals or trippy headspace. I would describe Mipla same way, yet really enjoyed that one. There was someone on here a few years ago who said we all have the wrong LSZ isomer the other one was the good one, IDK
 
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