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☛ Official ☚ The Big & Dandy HBWR/MGS/LSA Thread - Part 3: Fluffy Dreams Continued

⇧ I just checked the post behind a VPN and incognito mode and the reply I made is up! Can someone else with an IG acct. check the post too, to verify?
 
This is from TiHKAL entry #26 on LSA causing a tired, dreamy state with an inability to maintain clear thoughts. The implication is that psychedelic effects are due to other alkaloids in MG/HBWR seeds including LSH and the clavine-type alkaloids.

LA-111 Ergine, d-Lysergamide (LSA).
This is an active compound and has been established as a major component in morning glory seeds. It was assayed for human activity, by Albert Hofmann in self-trials back in 1947, well before this was known to be a natural compound. An i.m. administration of a 500 microgram dose led to a tired, dreamy state with an inability to maintain clear thoughts. After a short period of sleep, the effects were gone and normal baseline was recovered within five hours. Other observers have confirmed this clouding of consciousness leading to sleep. The epimer, inverted at C-8, is isoergine or d-isolysergamide, and is also a component of morning glory seeds. Hofmann tried a 2 milligram dose of this amide, and as with ergine, he experienced nothing but tiredness, apathy, and a feeling of emptiness. Both compounds are probably correctly dismissed as not being a contributor to the action of these seeds.

A related quote:
Alkaloid extracts should not be referred to as LSA, unless one has purified LSA and eliminated all other alkaloids found in the seeds etc. Shulgin and many others who researched this stated they did not think that LSA was the active alkaloid in these seeds, but that other alkaloids were. LSA is the majority alkaloid, but there are others present that are much more likely candidates for psychedelic effects.

Who has been able to obtain pure LSA from a chemical supply house and taken it?

The only accounts I know of using pure LSA are not psychedelic accounts.
 
I did HBWR as my first psychedelic.

When I was 14 (started w drugs really early), I acquired 17 HBWR seeds from my friend. Eager to throw myself headfirst into the world of psychedelic drugs, I decided to make a tea with all 17 of them. I was aware this was a big dose, but really didn't want to half the dose and then have to wait until I could acquire psychedelics again.

When I drank the tea, it didn't work. I must have suspected this might happen, and ate the remains inside the tea-bag. This worked! Within an hour or two I was tripping. The effect to my young mind was remarkable. I called my friend who I got them from and made some sort of comment about everything that could happen will happen because the universe is- and then I threw up very suddenly, no warning, all over the floor. I was completely mortified. I figured I had poisoned myself.

I laid on the ground for the rest of the night, confused and sad that my life turned out to be a tragic story where I died as a young teen from taking too many drug-seeds. and then I slowly realized over the next couple hours that I wasn't actually dead, or going to die.

I'd try them again, honestly. I haven't done much research on them since or encountered them. I will say, they felt nothing like LSD to me. Very sedating honestly. At this dose, they were much more visual than I would expect from LSA (according to anecdotes I read around that time) if my memory serves me right.
 
I will say, they felt nothing like LSD to me. Very sedating honestly. At this dose, they were much more visual than I would expect from LSA (according to anecdotes I read around that time) if my memory serves me right.

Can you elaborate, because it sounds like you contradicted yourself.
 
Can you elaborate, because it sounds like you contradicted yourself.
I'm not sure where I contradicted myself. They were sedating but still relatively visual and they didn't feel like LSD, though I am comparing them way after having tried both.
 
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I decided to make a tea
Tea as in, you put them in hot water? Lysergamides experience noticeable degradation from heat, not complete degradation but definitely a significant and noticeable amount. For future reference, cold water extraction (as long as the water is acidic and not basic) is a much more effective way to not accidentally waste LSA containing seeds.
 
I'm not sure where I contradicted myself. They were sedating but still relatively visual and they didn't feel like LSD, though I am comparing them way after having tried both.

They were relatively visual but they didn't feel like LSD: what does that mean?
 
They were relatively visual but they didn't feel like LSD: what does that mean?
I am not the person you're quoting here, but I actually feel identically about my LSA/HBWR experiences and if I were to attempt to describe this, I would say that while the visuals are noticeably intense and carry a more mushroom-like character with LSD's sharpness attached, the cognitive feeling was much more like ayahuasca or mushrooms. The headspace was pretty hazy and foggy, with a strongly noticeable note of profundity and the capacity to induce mystical/transformative experiences that I would likely need to spend hours integrating, whereas LSD induced mystical/transformative experiences that I would only need to spend 15-30 minutes meditating to meaningfully integrate. I often describe LSA as being like LSD's cousin that ended up on the hazier side of things, standing closer to ayahuasca and mushrooms than LSD or mescaline which are significantly more clear headed for me.
 
I often describe LSA as being like LSD's cousin that ended up on the hazier side of things

This is from TiHKAL entry #26 on LSA:
LA-111 Ergine, d-Lysergamide
This is an active compound and has been established as a major component in morning glory seeds. It was assayed for human activity, by Albert Hofmann in self-trials back in 1947, well before this was known to be a natural compound. An i.m. administration of a 500 microgram dose led to a tired, dreamy state with an inability to maintain clear thoughts. After a short period of sleep, the effects were gone and normal baseline was recovered within five hours. Other observers have confirmed this clouding of consciousness leading to sleep. The epimer, inverted at C-8, is isoergine or d-isolysergamide, and is also a component of morning glory seeds. Hofmann tried a 2 milligram dose of this amide, and as with ergine, he experienced nothing but tiredness, apathy, and a feeling of emptiness. Both compounds are probably correctly dismissed as not being a contributor to the action of these seeds.

It's possible that any psychedelic effects you are describing are due to the other alkaloids in MG/HBWR seeds including LSH and the clavine-type alkaloids.
But there is a habit (tradition?) of referring to HBWR/MG extracts as "LSA" which further confuses things.
 
It's possible that any psychedelic effects you are describing are due to the other alkaloids in MG/HBWR seeds including LSH and the clavine-type alkaloids.
But there is a habit (tradition?) of referring to HBWR/MG extracts as "LSA" which further confuses things.
This would almost certainly explain the difference in sedation/hazy qualities present between cold water extracts, ethanolic extracts, and eating the seeds straight. I always found CWEs to be the shittiest as far as being super sedative and cloudy, whereas ethanolic extracts were maybe a 4/5 improvement, and eating the seeds straight (only for HBWR, not MG/Christmas vine) was a 5/5 improvement, making my body feel great with less nausea than mushrooms would induce, and significantly brighter visuals with a more clear headspace.
 
the clavine-type alkaloids.

Didn't you see my post about clavines? One thing I forgot to add to that post was info from Heim 1968[1]—the only study that administered pure lysergol to volunteers, by itself:

"Lysergol showed the least pronounced subjective changes."

"Changes occurred only with a dosage of 8 mg,"

Lysergol is a clavine.

That 8 milligram figure needs strong emphasis…

Based on the average of the data from a 2016 study of I. tricolor seeds,[2] I. tricolor seeds contain approximately 17 micrograms of lysergol per gram. For comparison, I. tricolor seeds contain an average of 136 micrograms of LAH per gram.

Let's also try to establish a benchmark of psychoactivity. Although Hofmann never ingested pure LAH, he did ingest pure LAA and pure lysergic acid hydroxyisopropylamide (a.k.a. ergonovine). In The Road to Eleusis, he states, "The effective dose of lysergic acid amide is 1 to 2 mg by oral application." He adds to this, "ergonovine possesses a psychotropic, mood-changing, slightly hallucinogenic activity when taken in the same amount [as] an effective dose of lysergic acid amide,".[3]

I asked Grok to search numerous databases that contain I. tricolor trip reports (this site, Erowid, The Shroomery, et. al.) and the highest reported dose it found was 30 grams of seeds, which is roughly 1,000 seeds,[4] which confirmed what I have gathered from looking at comments over the years (i.e., 1,000 is approximately the limit). So, even if you consumed 1,000 seeds, you wouldn't even get a single milligram of lysergol.


1. Heim E, Heimann H, Lukács G. 1968. Die psychische Wirkung der mexikanischen Droge „Ololiuqui“ am Menschen. Psychopharmacologia 13 (1): 35–48. doi:10.1007/BF00401617. [quotes translated from German]

The first quote comes from Results / e) Symptom Distribution; the second quote comes from Results / c) ᴅ-Lysergol

2. Identification and determination of ergot alkaloids in Morning Glory cultivars. Nowak J, Woźniakiewicz M, Klepacki P, Sowa A, Kościelniak P. 2016. Anal Bioanal Chem. 408(12):3093-102. doi: 10.1007/s00216-016-9322-5

3. The Road to Eleusis: Unveiling the Secret of the Mysteries. 1978, 2008. R. G. Wasson, Albert Hofmann, Carl A. P. Ruck, Peter Webster. Chapter 2. A Challenging Question and My Answer, pages 40 & 41.

4. Averaging four figures given by two different seed suppliers yields a figure of 27.5 seeds per gram. 27.5 × 30 (grams) is 825 seeds.

Weber Seeds — Ipomoea tricolor “Heavenly Blue” — “Seeds per gram: 30”
https://weberseeds.nl/eshop/en/Seeds/Seeds-A-Z/Ipomoea-tricolor-Heavenly-Blue::81.html

Weber Seeds — Ipomoea tricolor “Pearly Gates” — “Seeds per gram: 30”
https://weberseeds.nl/eshop/en/Seeds/Seeds-A-Z/Ipomoea-tricolor-Pearly-Gates::82.html

OSC Seeds — Heavenly Blue Morning Glory Seeds 5750 — “Approx. 25–30 seeds/pkt (25 seeds/gram)”
https://www.oscseeds.com/product/heavenly-blue-morning-glory-seeds-5750/

OSC Seeds — Pearly Gates Morning Glory Seeds 5775 — “Approx. 25–30 seeds/pkt (25 seeds/gram)”
https://www.oscseeds.com/product/pearly-gates-morning-glory-seeds-5775/
 
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Nice 7 page thread, read most of it.

p.s. I am a lab chemist, 30 years experience, made a ground breaking discovery on how to make LSI from LSA in less than 1.5 hour, the experience with 25 HBWR seeds is even beyond that of 100ug of ALD-52

The 8 hour long experience is like a combination of ALD-52 and mescaline, hits way more brain receptors than LSD.

Book will be released end of December 2025: "LSI, ancient LSD, secret of the Eleusis Kykeon" and will appear on McKenna Academy podcast, the Brainforest Café in January of 2026, view on you tube.

LSI, ancient LSD, Secret of the Eleusis Kykeon and Vedic SOMA

Contents

Preface: Questions and Answers

Chapter 1: The Shaman on the wall

Chapter 2: The Eleusinian Mysteries

Chapter 3: SOMA, the divine Elixir of Vedic India tradition

Chapter 4: The Effects of LSI and how she was discovered

Chapter 5: Theoretical Simulation of the Claviceps Paspali based Eleusis Kykeon brew grown on barley:

Experiment 1: 25 HBWR seeds yielded 130mg LSA extract residue (25 x .04mg LSA per seed) = converted to LSI/LSV/LSC= felt exactly like 100ug of LSD, but even beyond LSD (like combo of ALD-52 + mescaline)

Experiment 2: 25 HBWR seeds yielded 139mg LSA extract residue (25 x .04mg LSA per seed) = converted to LSI/LSV/LSC again felt exactly like 100ug of LSD, but even beyond LSD (like combo of ALD-52 + mescaline)

Experiment 3: 30 HBWR seeds yielded 160mg LSA extract residue (30 x .04mg LSA per seed) = converted to LSI/LSV/LSC felt exactly like 120ug of LSD, but even beyond LSD (like combo of ALD-52 + mescaline)

Chapter 6: Reference: ALD-52 and mescaline trip reports from experienced psychonauts in the literature (combo of both similar to LSI + LSV + LSC Eleusis Kykeon simulation triple action): compare to LSD.

Chapter 7: A brief history of morning glory seeds, HBWR seeds and LSH or Lysergic Acid Hydroxyethylamide

Chapter 8: Psychedelic Brain Receptorome discovery

Chapter 9: The important role THH or tetrahydroharmine plays in traditional Ayahuasca discovery

Chapter 10: How to make THH or tetrahydroharmine: Caapi feminine teaching Spirit discovery

Chapter 11: Theoretical Aloe vera enhanced penetration Ayahuasca capsules discovery: relation to Jonathan Ott’s early 1990s experiments.

Chapter 12: Theoretical Zero nausea Bridgesii cactus tea

Chapter 13: Healthier way to consume legal THCA herb

Chapter 14: DMSO, nature’s healer

Chapter 15: House music life long pleasure and inspiration

Chapter 16: Life long keto diet and basic weight lifting and cardio program

Chapter 17: Walking outdoors in nature daily for 1.5 hour

Chapter 18: Philosophy

Chapter 19: A summary of the ALDHI method from James my chemist associate friend

Chapter 4 question:

When you performed these experiments, why didn’t you go above the equivalent of 120ug of LSD?
I did not feel the need to exceed the equivalent dosage of 120ug LSD (subsequent experiments) as I found the resulting psychedelic experiences to go above and beyond anything I could have ever hoped for. I give a trip report after each experiment forming a combo of LSI, LSV and LSCr.

1) The experience lasts 8 strong anxiety free hours with a 10 hour duration
2) There is a pleasant stimulation all night long into the wee hours of the morning, just like ALD-52 or mescaline exerts
3) The strength becomes stronger and stronger until she reaches a peak 3.5 hours in
4) There are profound Spiritual revelations, insights and intense healing, she is a feminine teaching spirit.
5) A brilliant diamond like shimmering of all visuals, infinitely fascinating
6) Tracers with open eyes as powerful as lightning strikes, none of the choppiness of LSD visuals, rather the visuals are flowing.
7) Intense, bold neon-like colors are seen all night, just like a combo of ALD-52 + mescaline, far, far more colorful than LSD. I have seen neon colors like purple-yellows, red-greens, and orange-blues that don't belong on this earth
8) Infinite way over the top euphoria felt all night (just like a combo of ALD-52 + mescaline). Anyone who has ever had cactus understands the mescaline euphoria I am talking about.
9) The beauty seen with open eyes is infinite and divine, no words to describe. This was one of the main reasons I took this psychedelic, the enhancement of beauty is just so over the top, extreme and heavenly.
10) The closed eye-colored geometrics seen which progress to real visions the longer the eyes are kept closed are just like what you see on a combination of LSD + mescaline, hundreds and hundreds of way beyond 4k visions many of them playing as if in a movie.
11) The music enhancement is just incredible and heavenly. I've felt more with this LSI, LSV and LSCr combo than with any traditional psychedelic except for mescaline that I was an extraterrestrial being, immersing myself in new sensory phenomena for the first time. Where LSD heightens and clarifies the sense of hearing, this Eleusis kykeon brew simulation produces auditory hallucinations, heightening the hearing sense but also causing sounds to be quite different than normal. I am a music lover and always listened to house music most of the night during the experiences, as on LSI, LSV & LSCr combo, every instrument and beautiful voice stands out on its own, every song is "epic". Like hearing a song for the very first time.
12) As for aphrodisiacal use of LSI, LSV & LSCr combo, wow! it brought energies out of me that I never knew I had.
13) There is zero or no anxiety with this potent 3 psychedelic combo, just like with ALD-52. This would explain why there were no bad trips reported in the Eleusis Kykeon literature.
14) There are no physical side effects: no body load, no nausea, no vasoconstriction, no cramping, just pure psychedelic bliss.
15) The next morning (I would typically get 6 hours sleep after the experience) I felt re-born with a massive serotonin "reset". I would go walking in nature with my shih tzus the following morning and all of nature looked as if brand new with a curiosity of nature's divinity.

Note: I do not recommend using morning glory seeds, only HBWR seeds...my results with up to 150 morning glory seeds were extremely disappointing (even below threshold effects), I believe the mg seeds are mainly 75% clavine alkaloids with less than 25% LSA, the levels of LSA in mg seeds being probably around .001mg per seed vs HBWR seeds at .04mg per seed. The morning glory seeds resulted in zero entheogenic effects, no euphoria, no stimulation, no visuals, and even no physical symptoms like dilated pupils...do not use. Stick only with HBWR seeds.

--> The few easy steps from Chapter 3 are in the book, drawn as black and white sketches, most of the time is spent waiting 20 minutes between the 3 basic steps. <-- LSI is forming internally (in vitro) in the liver, this is all explained in book.

 
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Blocked by shulginfoundation for posting this on one of their posts:


"Over 200 compounds synthesized and tested."

One compound he didn't synthesize or test is lysergic acid amide. He actually published one of the stupidest things that has ever been published in psychedelic literature about this compound. He says lysergic acid amide does not contribute to the psychedelic effects of morning glory seeds. He actually read a description of the effect of LAA that was published by Albert Hofmann and included a butchered paraphrasing of Hofmann's description in TiHKAL, which is much more popular than any of the few publications that contain descriptions of pure LAA.

"This is an active compound and has been established as a major component in morning glory seeds. […] The epimer, inverted at C-8, is isoergine or d-isolysergamide, and is also a component of morning glory seeds. […] Both compounds are probably correctly dismissed as not being a contributor to the action of these seeds."

Some quotes from Hofmann, for the record:

"… tiredness, apathy, a feeling of mental emptiness and of the unreality and complete meaninglessness of the outside world."[1]

"Already at that stage we had, in experiments on ourselves, ascertained a psychotomimetic activity with a marked narcotic component with dosages of 0.5 to 1 mg."[1]

"The experience had some strong narcotic effect, but at the same time there was a very strange sense of voidness. In this void, everything loses its meaning. It is a very mystical experience."[2]


"Not a contributor to the action of these seeds." 🤣

Thanks a lot, Shulgin. As if LAA didn't have a bad enough reputation to begin with. You have discouraged an untold number of people from experimenting with something that is readily available…unlike those 200 compounds.

"Im actually pretty suprised LSA doesnt get more attention as it is a truely great substance. I can actually admitt I like it evenly with LSD. All you hear about is people eating Hawaiian Baby Woodrose Seeds or Morning glories or sometimes Ololiuhqui. Some people even make crude alcohol extractions. I made a purified extract, with staggering results." (Kash, 2012-03-05, DMT-Nexus: Pure LSA Extraction (324044))


References

1. The Active Principles of the Seeds of Rivea corymbosa and Ipomoea violacea [sic]. Albert Hofmann. 1963-11-22. Cambridge, MA: Botanical Museum, Harvard University. doi: 10.5962/p.168542. Pharmacological and clinical activity of the isolated alkaloids

2. Stanislav Grof Interviews Dr. Albert Hofmann. 1984. MAPS Bulletin 9.2, Fall 2001: 22–35.
I think the rather impolite nature of your correction is the reason for you being blocked.

Sasha was often wrong and would always enjoy a discussion and being corrected.

Why he did say that LSA/LAA was not responsible for the action of the seeds is an interesting conjecture. Unfortunate he is not around to further discuss the premise of that idea.
 
Why he did say that LSA/LAA was not responsible for the action of the seeds is an interesting conjecture.
I think this is because it has a mostly uninteresting sedative-type effect. Shulgin was correct.

Kash enjoyed botanicals which produce lysergamides as he was well-aware of the creation of LSA adducts with aldehydes. Kash used sources of aldehydes in his extractions with great results.
"Im actually pretty suprised LSA doesnt get more attention as it is a truely great substance. I can actually admit I like it evenly with LSD. All you hear about is people eating Hawaiian Baby Woodrose Seeds or Morning glories or sometimes Ololiuhqui. Some people even make crude alcohol extractions. I made a purified extract, with staggering results." (Kash, 2012-03-05, DMT-Nexus: Pure LSA Extraction)
 
Quote:

In this 1998 interview, psychologist and psychedelic pioneer James Fadiman, PhD, recalls one of his most transformative psychedelic visions.

During a session with morning glory seeds (which contain lysergic acid amide, or LSA, a close analog of LSD) Fadiman describes seeing himself at an enormous blackboard, meticulously mapping a sophisticated theory of reality as illuminated by psychedelics.

Then, in the vision, God appears, praises the work, and calmly erases it all.

When Fadiman protests, God replies with gentle amusement: the analysis was beautiful, but ultimately beside the point.

The deeper message, Fadiman realizes, is that the odds of fully grasping reality in this body, this lifetime, and this civilization are essentially zero. And yet, the attempt itself is joyful and nourishing.

What followed was not nihilism, but liberation. Fadiman describes how this vision untethered him from rigid certainty, loosening his attachment to “core beliefs” he once assumed were fixed.

This story reminds us of a central paradox of the psychedelic experience: it may not give us the final answer to the universe, but it can soften our need for one.

In letting go of the illusion of ultimate knowing, Fadiman discovered something more profound and enduring: the freedom to explore reality with reverence, humor, and lightness.

Source: Psychoactive Substances Research Collection, Purdue University Libraries — “Pioneers in Research” interview series, 1998.

h‍ttps://www.instagram.com/psychedelicarchives/reel/DRfRxGGDwgk/ 2025-11-25
 
Rebuttal to @tregar's lysergic acid isovaleraldemide hypothesis from @xdrc:

The adducts between indoles with aldehydes + alcohols are of course structurally different from your proposed LSI formation - and requires some alcohol in the mixture too, alongside the experiments being conducted at a pH of 3. The literature on the synthesis of adducts of amides with aldehydes starts from anhydrous consitions (with water as solvent as you propose in your method would drive the equilibrium in the wrong direction), the yields are low and require high temperatures. The product - if it formed in the first place - would not be LSI but a dimeric adduct. For both of these reactions way longer reaction times than 20 min are needed to get any appreciable yields. If these referenced reactions happened it is quite unclear to me if these compounds would perhaps act as some sort of pro-drug, but I have my doubts for many reasons.

I think you are mainly having yourself fooled with these experiments. You seem very convinced that this actually works (either in vitro or in vivo, but I'm doubtful of both, would like to see the suggested reading for in vivo though). Psychedelics are very amendable to expectations via the placebo and nocebo effect. I would recommend doing a couple of self-blinding studies (easier together with a friend). I would be surprised if you could distinguish the effects of the extract from one with added aldehydes (of course you need to ensure the successful blinding over the whole trials, say at least 3 experiences with each before unblinding -> verifying).

I'm surprised that as a lab chemist of 30 years, you fail to see the need for analysis and found no way to arrange such. Isn't there a company precisely called "Kykeon" which seems befitting of such a task - among a couple other options? Of course if you're shifting gears to an in vivo activation everything will be a bit harder, but I do recommend the blind test for a first evaluation. It is puzzling to me that any different effects with psychedelics are always first attributed to entourage effects, side products, etc. when it's been clear for many many many years that mind, soul and body are perhaps the most important contributors to the psychedelic experience.

I'd be curious how you address these concerns. I'm sorry if I missed it in the texts, it was frankly quite unstructured and rambling. I'd recommend some touch up before an eventual release of the book. There are other inaccuracies too - for instance with HWBR as a natural product the amount of LSA will anything but be constant, unlike you assert.

I find this case very curious. Because even if the effects are just simply mediated by LSA and a placebo effect, there is much to learn here, don't you think? But regarding your proposed formation of LSI, I don't see how this would happen at all. It should be clear that the burden of proof lies on the person trying to sell a book, especially with being so out of the scope of published works from what I am aware.

PS: I must also admit I'm quite suspicious of Allylbenzene being more than just a "chemist associate" to you.

xdrc, 2025-11-30, https://www.bluelight.org/community/posts/16354410
 
"The two amazing trips that I did have on LSA was really nice because it had a very relaxing, narcotic/sedative-like cerebral clear high to it. It's perfect because at no point at all did I experience anxiety or any negative feelings. (When it went well). If I could replicate that feeling, I'd take it all the time."

"LSD gives me huge bits of anxiety on the comeup and is very stimulating (which is great for exercising, like bike rides, walking, dancing, etc) but the extra energy can defitely lead to some nervous energy on the come up. That all goes away when it starts to peak, but the comeup can be a lil rough for me."

TrancedOutBrah, 2024-09-23, https://www.shroomery.org/forums/showflat.php/Number/28959155#28959155
 
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