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☛ Official ☚ The Big & Dandy HBWR/MGS/LSA Thread - Part 3: Fluffy Dreams Continued

Reported by a member. Just thought since we are letting all thoughts in I would post this one. Lots of refuting in this thread. But that is what research is for.

"LSI is not a psychedelic drug. It's a physiologically unstable schiff base. It could be converted to a secondary amine via reductive amination, but that would no longer be LSI. The secondary amine could be psychedelic or physiologically stable, but that hasn't been studied."
 
"Ergine is classified as a depressant federally. Erginine isn't classified at all. It is definitely stimulating, but I have not taken above 1 mg. 7 seeds (a. nervosa) were smashed and added to orange cool-aid. The mixture was frozen, thawed and then 1 teaspoon of baking soda was added. 0 nausea and mild vasoconstriction consistent with an ergine dominant preparation."
 
donotdothis said:
Explaining decrease of vasoconstriction with the newest methods:

"Isoergine and ergine are relatively small, highly lipophilic molecules. Ergobalansine (and its epimer ergobalansinine) are significantly larger, preventing them from efficiently penetrating within a short timeframe."
Click to expand...

I had to heavily edit this post but it should be perfect. It originally had ergobasine.

pubchem.ncbi.nlm.nih.gov

Ergometrine

Ergometrine | C19H23N3O2 | CID 443884 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
pubchem.ncbi.nlm.nih.gov pubchem.ncbi.nlm.nih.gov
pubchem.ncbi.nlm.nih.gov

Ergobalansine

Ergobalansine | C28H35N5O5 | CID 14753572 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
pubchem.ncbi.nlm.nih.gov pubchem.ncbi.nlm.nih.gov
 
JackARoe said:
Reported by a member. Just thought since we are letting all thoughts in I would post this one. Lots of refuting in this thread. But that is what research is for.

"LSI is not a psychedelic drug. It's a physiologically unstable schiff base. It could be converted to a secondary amine via reductive amination, but that would no longer be LSI. The secondary amine could be psychedelic or physiologically stable, but that hasn't been studied."
Click to expand...

I'd clarify that quote by stating that LSI refers to a condensation product formed between (at least) LSA and isovaleraldehyde (3-methylbutanal). Claiming that it's not psychoactive seems hasty. Understandable of course, but hasty still. The name LSiV seems more appropriate.
 
The psychoactivity of LSI isn’t what is under debate. Adduct formation in an aqueous environment just isn’t going to happen.


A member even tried to make it based on instructions posted en masse in that one thread, and ran TLC plates that showed no chemical change between the seed extract and the one treated with aldehyde.
 
Allylbenzene said:
Indeed, of this I'm aware.


The same criticism is levelled at all the adduct formations, eg performed using a tincture of cinnamon & cumin (reported by user flickedbic) or sassafras bark (reported by user lysurgeon).
Click to expand...
Well that makes sense. There has been no evidence that aldehydes can form stable adducts in >99% aqueous solutions, and there is evidence that this doesn’t occur.
 
Skorpio said:
There has been no evidence that aldehydes can form stable adducts in >99% aqueous solutions, and there is evidence that this doesn’t occur.
Click to expand...

All I can reasonably deduce from the reports is that anhydrous conditions aren't imperative for this LSA/aldehyde "rxn" to occur.
 
"This has been my first time ever trying a psychedelic and I’m tripping rn i originally took 6 and threw up after 30 minutes before I felt effects, I then resided with 2 seeds sublingually and like probably 8 wfter to get the effects I want, I am trying hard to type this, listening to seek and destroy, I feel at one with everything."

 
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