Lysergamides The Big & Dandy ETH-LAD Thread

[Goodwalt]

Al-LAD is the easiest and friendliesr lysergamide I've tried. I would recommend being with at least one friend during it, as for me, it really makes me want to socialize and laugh, it's not so much for introspection. ETH-LAD is much more powerful and introspective.

Thanks for the reply, Xorkoth and MSK I'll probably take AL-LAD with my gf and a couple of friends. What ROA do you think is best? I was thinking of doing it sublingually and then swallowing after a while.

 

[Xorkoth]

Sublingual and oral are basically the same for LSD since it's absorbed fundally, I would imagine the same is true of other lyseragmides though I'm not sure. So yeah, hold it in your mouth and swallow after a while.

 

[drseltsam]

David Nichols says in his talks that for lsd he thinks that the two phases are due the addition a metabolic OH group at the six position. He and his team verified this in rats but not in humans.

This might also be the case for ETH-LAD being metabolized to 6 hydroxy ETH-LAD.

 

[pupnik]

I am giving a friend of mine two tabs of this.
He wants to try micro-dosing.

one I cut into 6 pieces for 10-20 mic doses
the other I cut into 4 for 20-30 mic doses

I think it's the closest to lsd so I think he will get the idea, my suggestion is to do every third day at the most, or capitulate and eat a few of them at once for some fun

 

[Hodor]

He wants to try micro-dosing.

I think it's the closest to lsd so I think he will get the idea, my suggestion is to do every third day at the most, or capitulate and eat a few of them at once for some fun

The closest to LSD would be either 1P-LSD or ALD-52, since those are generally accepted to get converted to LSD in the body.

ETH-LAD, on the other hand, produces a different headspace that feels much lighter than LSD's at lower doses (~100µg), yet more overwhelming at higher doses (200+ µg).

And seeing as how ETH-LAD is no longer getting produced, using it for microdosing would be downright wasteful

 

[pupnik]

well it's a really good friend. I could shift to 1p when he runs out, if he likes it.

 

[Solipsis]

Very interesting @ article in Cell... if LSD does that to a 5HT2A receptor for hours which seems astronomical in terms of dissociation constants, wtf is an NBOMe doing worse to it to make it toxic? Seems like we're missing quite a bit....
I was skeptical about the 2 phase concept and explanation for LSD in these terms and using the article at first, but I like it now

 

[pupnik]

obviously besides actual determination of what happens after the 5HT receptors are bound and made active (i.e. what do actually they do when activated?),
might the same receptor sites actuate differently when the rest of the fitting molecule has other electro-mechanical action from functional groups that may drag it one way or push it another.
meantime NBOME may hit other binding sites as well before or after getting jiggy with 5HT's

 

[Kaleida]

I recently had a second eth-lad trip at 200ug.
The thing I noticed is that at almost exactly the 4 hour mark the visuals suddenly really peak. On both my 200ug trips I have had what I can only describe as fireworks going off in my vision, so realistic that on my first experience I actually thought they were real!

This really ties in with the mentioned two stages. I've found that the first stage is fairly introspective; on this occasion I figured out that I need to look after myself better. I've lost a lot of weight recently (deliberately, at first certainly) and believe I have become too thin. I wanted to lose weight and then exercise to get in better shape so I now need to follow through.

The second phase is pure euphoric hedonism. On recent trips I have been revisiting some old albums: I have to say that Leftism by Leftfield is astounding whilst tripping (even straight). Song of Life had me gyrating wildly and shaking my boots like crazy. Also listened to The Go! Team's 'Thunder, Lightning, Strike'. Rarely has a more uplifting album been made and the track Ladyflash is possibly the pinnacle. Also a track called 'Hold yr Terror Close' is one of the most beautiful ever recorded.

This stuff is disappearing soon. I recently received 25 tabs and will order another 100 to keep for special times.

Very interesting, thanks for sharing! Yeah, regardless of the reason behind it, these lysergamides definitely do seem to have a two phase thing going for them, more so than psychedelics often tend to anyway. It's pretty fascinating.... It definitely makes me even more excited to explore more with them while we still can! I can't wait to have a trip on ETH-LAD like you describe, I think I am going to try 200 ug next time.

David Nichols says in his talks that for lsd he thinks that the two phases are due the addition a metabolic OH group at the six position. He and his team verified this in rats but not in humans.

This might also be the case for ETH-LAD being metabolized to 6 hydroxy ETH-LAD.

That's one I haven't heard before. Do you have like a link to him saying it or anything?

Very interesting @ article in Cell... if LSD does that to a 5HT2A receptor for hours which seems astronomical in terms of dissociation constants, wtf is an NBOMe doing worse to it to make it toxic? Seems like we're missing quite a bit....
I was skeptical about the 2 phase concept and explanation for LSD in these terms and using the article at first, but I like it now

Good question.... I'm very curious about the interactions of NBOMes with the 5-HT2A receptor myself. I definitely agree, the overall picture of 5-HT2A receptor activity must be very complex.... I am still constantly amazed by how consistently different the effects of one psychedelic can be from the next, no matter how many similarities there are, it's clear that the physical interaction between the receptor and the ligand must play a particularly significant role here, as this LSD study just further captures.

And glad you think so, I think it's a cool idea. It's got me thinking up possible analogues now, like other ways the basic tryptamine structure could be extended and manipulated to make these pockets for itself, and how both the metabolic half-life and the dissociation constants could be altered together.... I think it'd be interesting, for instance, if there was a molecule that stuck to the 5-HT2A receptor for about as long as psilocin, but was metabolized nearly instantly like smoked DMT, theoretically minimizing any non-5-HT2A toxicological impact or off target receptor complications, and the 5-HT2A part would just be addressed through pharmacological specification. It'd be cool to find a base like that to start with and then start building outward from there to find derivatives of different overall duration and therapeutic impact like Dr. Shulgin did, just with an updated manmade blueprint rather than the historically used natural psychedelics.

It's neat to imagine where human understanding of psychedelics might be hundreds of years from now assuming that the research continues.

obviously besides actual determination of what happens after the 5HT receptors are bound and made active (i.e. what do actually they do when activated?),
might the same receptor sites actuate differently when the rest of the fitting molecule has other electro-mechanical action from functional groups that may drag it one way or push it another.
meantime NBOME may hit other binding sites as well before or after getting jiggy with 5HT's

Can you give an example of what you mean? I'm following you a bit but not totally sure what you're trying to say here.

 

[pupnik]

all I am saying about the lysergic family is that we know that these receptors can be triggered to // somehow // start the psychedelic states, but this set of states is not at all modeled at the cellular and tissue levels in a way that would support the experiences we get.

 

[Vt K]

so its official these have beeen discontinued? who has confirmed this and where ?

surely at any moment a lab can decide to synthesize it?

 

[Goodwalt]

I ordered them a couple of weeks ago and the vendor is still offering them. I don't think they are going anywhere for the moment, but it's a possibility.

 

[cj187]

The two biggest vendors selling it have said that it isn't going to be produced any more. They still have enough left of the last batch to keep selling it for 6 months to a year. They're looking for a new lab to produce it but not many labs are capable of doing it.

 

[Solipsis]

We need a Lysenberg

 

[Vt K]

Guys im so nervous and excited... Going to ingest 300ug ETH LAD in about ~60 minutes.

I took 40mg 4 AcO DMT 5 days ago, before that about 5 days i took 60 mg 4 HO MET and about a week before that 60mg 4 AcO DMT.. i have been consuming psychadelics entirely too much and i feel im wasting this precious experience but its such a glorious february day.. 55 degrees . i dont expect to get any insight or anything like that because ive exhausted that through the previous trips.

Just curious what eth lad has to offer. Ita so goofy that im nervous because when i got bad into LSD i was consuming 4 to 6 hits every week or so.. but its the nervousness of something new xD

 

[perpetualdawn]

Have you taken ETH-LAD before? Because 300µg is a lot of it, but then you probably have tolerance from tripping pretty frequently by the sounds of things. I'd recommend going a little bit less if it's not too late and it's your first time. I got my ass whooped on 300µg!

 

[Solipsis]

How worth it is one blotter (100 µg) if you don't easily get strong trips?

Good idea to start with at least 150 µg then?

(Then again, if I end up tripping on saturday at home with carnaval throughout the city, I will likely not tempt fate xD)

 

[perpetualdawn]

I haven't tried 100µg, so can't say. If you don't easily get strong trips, I'd recommend going higher. My first time was 150µg, which was very strong, but awesome and felt perfect. I tend to trip really easily.

For a first try with it, I think an experienced tripper could do 200µg if you wanted to go for a strong dose right off the bat.

100µg-200µg is my recommendation for first time.

For reference 150µg felt to me stronger than any 2 tabs of acid I've ever taken, and well stronger than 16mg of 2C-E.
150µg of ETH-LAD was much much stronger than 150µg of AL-LAD or 150µg of LSZ. Maybe twice as strong subjectively as the AL-LAD, 1.5x the LSZ. Or so

 

[cj187]

150ug is a good starting dose. That's how much I took the first time I tried it, and I'm kind of kind of a lightweight with psychedelics. For me it's strong but easy to handle.

If you took 100ug I don't think you would be disappointed. I've taken 75 before and had a very satisfying trip.

I would recommend smoking weed when you take it. I don't smoke smoke weed much because it usually gives me bad anxiety, but every time I've taken ETH-LAD it has really enhanced the trip without giving me any anxiety.

 

[drseltsam]

Very interesting @ article in Cell... if LSD does that to a 5HT2A receptor for hours which seems astronomical in terms of dissociation constants, wtf is an NBOMe doing worse to it to make it toxic? Seems like we're missing quite a bit....
I was skeptical about the 2 phase concept and explanation for LSD in these terms and using the article at first, but I like it now

Sorry for the late reply. About the 2 phases please find the talk of David here. For me, this sounds very solid.

About the question why the NBOMes are that toxic and LSD is not but still binds excellent the 5HT2A: The classical picture is that the receptor is like a light switch. You put the ligand (the drug) in and it is "on". When the drug leaves the binding site it is "off" again. We do not know how LSD etc. work exactly and most certainly these compounds bind to more than one receptor in the brain. The point is that this picture is too simple. A receptor is not just a light switch with two modes (on and off). Depending on how you stimulate it, different signal pathways are triggered which might lead to very different reactions. In this way it is understandable that two compounds bind to the same receptor but trigger different pathways. Please find a better introduction to this here.