ALD-52 or 1-acetyl-LSD
iupac = (6aR,9R)-4-acetyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
- David Nichols supposedly said that 1-substituted LSD analogues like these have no activity at 5-HT2A themselves
- But, it does get broken down to LSD in the body, ALD-52 most likely more rapidly even than 1P-LSD. So at the very least you have the effects from the metabolized LSD.
- However like with psilocin esters, the kinetics alone could make a subjective difference, but since subjectivity is so hard to qualify, we don't know how different it is from LSD
- The safety is also unknown but I am not aware of any evidence suggesting that it isn't every bit as safe as LSD
- In any case, it's damn good for people who are unable to find LSD to have a "legal" substitute.
- There are some arguments like the high potency of ALD-52 or 1P-LSD not explaining the relatively limited LSD metabolite found, but I am skeptical of that since LSD potency is much more overstated whereas ALD-52 and 1P-LSD potencies advertised seem to on average be much more honest, coming from one major source and distribution chain. Also, there are pharmacological reasons why the threshold for these compounds is quite low, so the actual significance of these pro-drugs has not truly been demonstrated as far as I'm concerned. But there may be more to it of course!
s.
LINK TO PREVIOUS THREAD
posts from the previous thread:
My personal response to the above discussion:
Alcohol metabolism requires a lot of water and if already dehydrated for example as result of the heat, it indeed tends to have a heavier impact. THC is also quite hygroscopic and dehydrating at least in some ways, though I don't think the metabolism requires water, nor do I know any hangover to be in majority a function of how well you can keep compensating with hydration.
LSD does not dehydrate you and the rate of reaction of Ehrlich's reagent with it has absolutely nothing to do with the human body.
What's left though is that exhaustion makes you much more sensitive, both body and mind are highly connected in this. There are various ways of course to get exhausted, from your activity alone or lack of rest after activity or insufficient nutrition or hydration are main examples. These should still be factors that determine your set, and influence the outcome of a trip, but I don't see a reason why that should be more than for LSD or other psychedelics.
That means that in some sense I agree that there are comparisons with alcohol, which regardless of its further metabolism can hit harder when you are exhausted. But it should not go beyond that, as was partially suggested.

iupac = (6aR,9R)-4-acetyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
- David Nichols supposedly said that 1-substituted LSD analogues like these have no activity at 5-HT2A themselves
- But, it does get broken down to LSD in the body, ALD-52 most likely more rapidly even than 1P-LSD. So at the very least you have the effects from the metabolized LSD.
- However like with psilocin esters, the kinetics alone could make a subjective difference, but since subjectivity is so hard to qualify, we don't know how different it is from LSD
- The safety is also unknown but I am not aware of any evidence suggesting that it isn't every bit as safe as LSD
- In any case, it's damn good for people who are unable to find LSD to have a "legal" substitute.
- There are some arguments like the high potency of ALD-52 or 1P-LSD not explaining the relatively limited LSD metabolite found, but I am skeptical of that since LSD potency is much more overstated whereas ALD-52 and 1P-LSD potencies advertised seem to on average be much more honest, coming from one major source and distribution chain. Also, there are pharmacological reasons why the threshold for these compounds is quite low, so the actual significance of these pro-drugs has not truly been demonstrated as far as I'm concerned. But there may be more to it of course!
s.
LINK TO PREVIOUS THREAD
posts from the previous thread:
Our research has indicated that if the Ehrlich Reagent testing environment's temperature conditions are increased to around 90F, the reaction strength of ALD-52 is greatly increased and the time to reaction in such a test is greatly decreased.
Here's a 125mcg sample of ALD-52 from a popular European vendor tested over a 20 minute time period at 90F in a standard NIK D Ehrlich Reagent pouch (the same type most commonly used by law enforcement agencies).
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And here's a 100mcg sample of ALD-52 from a popular Canadian vendor tested over a 20 minute time period in the same testing environment using the same model testing kit as above.
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For contrast, here is a 25mcg sample and a 100mcg sample after 12 hours at room temperature in the same model testing kit as above. [Note: The reaction isn't nearly as strong and (obviously) quick.]
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Hope this info helps expand the knowledge base.
More testing to come with more compounds as increased access allows.
ALD-52 (like other lysergamides) contains an indole at the bottom of the molecule. This is why it reacts (albeit slowly at room temperature) in an Ehrlich Reagent test.
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Lysergamides:
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No, I meant that these substances are stronger when the weather is really hot. Like drinking alcohol and smoking weed under the sun. It definitely hits harder.
Yes. I just read an article about alcohol. It says that the bodycells are containing less fluid at higher temperatures and therefore the alcohol in the body is more concentrated. Therefore the impact is stronger and it sets in faster. Doesn't have to mean it's the same with Lsd, but with Thc I definitely feel the same. It always hits me stronger when I'm sitting under the sun.
My personal response to the above discussion:
Alcohol metabolism requires a lot of water and if already dehydrated for example as result of the heat, it indeed tends to have a heavier impact. THC is also quite hygroscopic and dehydrating at least in some ways, though I don't think the metabolism requires water, nor do I know any hangover to be in majority a function of how well you can keep compensating with hydration.
LSD does not dehydrate you and the rate of reaction of Ehrlich's reagent with it has absolutely nothing to do with the human body.
What's left though is that exhaustion makes you much more sensitive, both body and mind are highly connected in this. There are various ways of course to get exhausted, from your activity alone or lack of rest after activity or insufficient nutrition or hydration are main examples. These should still be factors that determine your set, and influence the outcome of a trip, but I don't see a reason why that should be more than for LSD or other psychedelics.
That means that in some sense I agree that there are comparisons with alcohol, which regardless of its further metabolism can hit harder when you are exhausted. But it should not go beyond that, as was partially suggested.
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