The Big & Dandy 6-APB Thread (Part 5)

[Esperighanto]

Thread 'APBT's - The next generation of psychedelic/entactogenic/empathogenic amphetamines is coming!!! Bring on the benzothiophenes!'

Mar 19, 2022

(2-Aminopropyl)benzo[β]thiophenes (APBTs) are novel monoamine transporter ligands that lack stimulant effects but display psychedelic-like activity in mice - Neuropsychopharmacology

Derivatives of (2-aminopropyl)indole (API) and (2-aminopropyl)benzofuran (APB) are new psychoactive substances which produce stimulant effects in vivo. (2-Aminopropyl)benzo[β]thiophene (APBT) is a novel sulfur-based analog of API and APB that has not been pharmacologically characterized. In the...

www.nature.com

According to this article benzothiophene based "amphetamines" are more potent releasers of serotonin than their benzofuranyl analogs. They also have a higher affinity for the 5-ht-2 receptors and cause rats to develop the stereotype head twitch which indicates psychedelic like activity.

Benzothiophenes are just like benzofurans except benzothiophenes have a sulfer where benzofurans have an oxygen (and indoles have a nitrogen).

The three chemicals that they picked out to highlight were 3-APBT, 5-APBT, and 6-APBT.

5 and 6-APBT are...

• simstim
• Replies: 17
• Forum: MDMA and Empathogenic Drugs

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For anyone who sees how much more dangerous 2C-T's (and expectedly ALEPHs) can be when compared to non-sulphur containing homologs, man these are kind of scary to think about. I wonder how many (if any) exhibit MAO inhibition.

 

[CavernsoftheMind]

We took 70mg 6-APB succinate 40min ago.
The taste was quite unpleasent - salty & sour. The color is light brown & it's from a famos NL vendor.
It starts to kick in I think - I get the typical heat flushes & slight uneasiness in the stomach.

We also took 10mg O-PCE 5h ago, which is slightly effecting us still.

It's gonna be a fun night I think - maybe we'll redose with 5-MAPB boofed, maybe take some more O-PCE + N2O.

Will report back.

 

[Neuroborean]

For anyone who sees how much more dangerous 2C-T's (and expectedly ALEPHs) can be when compared to non-sulphur containing homologs, man these are kind of scary to think about. I wonder how many (if any) exhibit MAO inhibition.

I hope it will be soon

 

[CavernsoftheMind]

Our night was great.
It was pretty heavy substance mixing, since this was the only day we could really go far out for the next 1 & 1/2 months or so.

We started with a small - moderate dose O-PCE (8,5mg) in the afternoon & watched a Ghibli movie & got us some vietnamese food.
Ghibli is the perfect match for low to mid disso doses.

Then we took the 70mg 6-APB succinate after being pretty much down from the O-PCE.
I had some nausea, all in all it was very pleasent though. Did some good open talking & some N2O balloons.
It was relatively strong for me, a bit mild for my trip partner (female). I guess I'm pretty sensitive to empathogens.

After 1 1/2 h we decided to add 40mg 5-MAPB rectally, which was a good choice. No nausea, pretty quick onset.

Then we smoked 2 40mg MET salt in an oil pipe, which made us have mild visuals & produced a mystical, therapeutical vibe.
N2O enhanced the effects considerably.

We redosed 2 more times with 40mg 5-MAPB rectally. A bit excessive, but bruxism wasn't too bad.

At like 2 or 3 AM we started to snort big ketamine lines & I had very interesting visual k-holes & my whole life got evaluated. My traumas surfaced & I remembered forgotten childhood memories, thought about the death of my parents, my kratom dependance, all my pains.

It was very demanding & hurt a lot. It did feel healing though (or at least now I have the chance to turn it to a healing experience by talking, writing & thinking about all that's going wrong in my life).

Now, after 5h of sleep, I still feel very opened, also tired & a bit sad.

This was extraordinary & I'm looking forward to experiment with MET on it's own in the future.

I had zero withdrawal symptoms even 24h after my last kratom dose btw, very unusual

 

[Neuroborean]

Our night was great.
It was pretty heavy substance mixing, since this was the only day we could really go far out for the next 1 & 1/2 months or so.

We started with a small - moderate dose O-PCE (8,5mg) in the afternoon & watched a Ghibli movie & got us some vietnamese foos.
Ghibli is the perfect match for low to mid disso doses.

Then we took the 70mg 6-APB succinate after being pretty much down from the O-PCE.
I had some nausea, all in all it was very pleasent though. Did some good open talking & some N2O balloons.
It was relatively strong for me, a bit mild for my trip partner (female). I guess I'm pretty sebsitive to empathogens.

After 1 1/2 h we decided to add 40mg 5-MAPB rectally, which was a good choice. No nausea, pretty quick onset.

Then we smoked 2 40mg MET salt in an oil pipe, which made us have mild visuals & produced a mystical, therapeutical vibe.
N2O enhanced the effects considerably.

We redosed 2 more times with 40mg 5-MAPB rectally. A bit excessive, bug bruxism wasn't too bad.

At like 2 or 3 AM we started to snort big ketamine lines & I had very interesting visual k-holes & my whole life got evaluated. Mz traumas surfaced & I remembered forgotten childhood memories, thought about the death of my parents, my kratom dependance, all my pains.

It was very demanding & hurt a lot. It did feel healing though (or at least now I have the chance to turn it to a healing experience by talking, writing & thinking about all that's going wrong in my life).

Now, after 5h of sleep, I still feel very opened, aldo tired & a bit sad.

This was extraordinary & I'm looking forward to experiment with MET on it's own in the future.

I had zero withdrawal symptoms even 24h agter my last kratom dose btw, very unusual

I'm just going through kratom withdrawals right now, one of the worst I went through, perhaps because my use scalated to around 18 grams a day, when normally I was around 10-12, it is like the first time but with more anxiety and less other symptoms, the kava kills the anxiety for a while, but not too much, gotta go for a big walk now before trying to sleep, just to see if it works, my sugar levels (I'm diabetice type 1) are wrecked, like I can barely eat and need to inject almost double insulin.
Your experiment seems interesting and worthwhile but I would honestly wouldn't do it, as it seems pretty unsafe (for my standards). At least you dosages werent' that high, so cool with that harm reduction.

 

[CavernsoftheMind]

I'm just going through kratom withdrawals right now, one of the worst I went through, perhaps because my use scalated to around 18 grams a day, when normally I was around 10-12, it is like the first time but with more anxiety and less other symptoms, the kava kills the anxiety for a while, but not too much, gotta go for a big walk now before trying to sleep, just to see if it works, my sugar levels (I'm diabetice type 1) are wrecked, like I can barely eat and need to inject almost double insulin.
Your experiment seems interesting and worthwhile but I would honestly wouldn't do it, as it seems pretty unsafe (for my standards). At least you dosages werent' that high, so cool with that harm reduction.

Ketamine alone in small to mid doses can reduce kratom withdrawal symptoms drastically.

A few 30mg lines + 1.25mg Lorazepam made withdrawal from 500-800mg O-DSMT a day rectally feel like a breeze. I only did that for the second & third day to not get addicted to ket / benzos though.

 

[Neuroborean]

Ketamine alone in small to mid doses can reduce kratom withdrawal symptoms drastically.

A few 30mg lines + 1.25mg Lorazepam made withdrawal from 500-800mg O-DSMT a day rectally feel like a breeze. I only did that for the second & third day to not get addicted to ket / benzos though.

I don't have NMDA antagonists atm, well, I have Huperzine A that has helped quite a bit in big doses, perhaps because it acts as a weak NMDA antagonist at that doses..
will pick it with me, as I need to do a long travel for2 days (kratom withdrawals while going through a "break up" with an avoidant girl and travelling, not a good moment honestly), will pick my kava kava bag, huperzine A, l-theanine and I have some diazepam and out of date of consumption lorazepam I have here. I hate benzos, but the reality is they help in those moments, I currently have insomnia like a "normal" thing, so the kratom insomnia is just impossible to overcome without a lot of stuff.

 

[PsychedelicSummer]

I don't have NMDA antagonists atm, well, I have Huperzine A that has helped quite a bit in big doses, perhaps because it acts as a weak NMDA antagonist at that doses..
will pick it with me, as I need to do a long travel for2 days (kratom withdrawals while going through a "break up" with an avoidant girl and travelling, not a good moment honestly), will pick my kava kava bag, huperzine A, l-theanine and I have some diazepam and out of date of consumption lorazepam I have here. I hate benzos, but the reality is they help in those moments, I currently have insomnia like a "normal" thing, so the kratom insomnia is just impossible to overcome without a lot of stuff.

Acupuncture, lifting weights also helps and ideally tapering.

 

[Allylbenzene]

I don't have NMDA antagonists atm, well, I have Huperzine A that has helped quite a bit in big doses, perhaps because it acts as a weak NMDA antagonist at that doses..

Huperzine A is also a potent acetylcholinesterase inhibitor which increases acetylcholine. This can contribute to mental stimulation/racing thoughts so be aware!
Theanine is also an NMDA antagonist and stops the cortisol stress response.

If you can, get agmatine which is excellent for reducing withdrawal symptoms. It's otc and fairly cheap. It shares similar properties to ketamine (NMDA antagonist, AMPA, mTOR).

 

[CavernsoftheMind]

Since there doesn't seem to be a 5-APB thread, I'll leave that here:


Took 20mg 5-APB (very white, supposedly HCl) in 0.5ml water rectally. Burned a bit.
After 30min it was clear it's an empathogen (we were cautious since it was the first time trying that batch) & redosed 60mg 5-APB in 0.5ml.
Burned a lot & quite long. Should have used at least 1.5ml water.

The effects were quite intense.
More intense than 80mg orally.
The comeup was even pretty harsh, I got very warm.

I think 60mg rectally are enough. I'm more on the sensitive side though.

We combined it with ket / 2FDCK after a while & it was a very lucid, long talk & a loooot of thinking about life.
The combo has therapeutic potential.

After effects were mild.