Ever wonder why many consider the Panaeolus experience incredibly unique?
"They are the cleanest, smoothest, most peacefull mushroom vibe of all the species I have tried. Panaeolus cyanescens and tropicalis rank #1 in my book."
"the highs real clean . its reminds me of the phelix the cat acid from the 80s . just smooth . with little body noise and extreme visuals . a calm lucidty that is like a slice of heaven"
"Pan Cyan (and Trops) are very much worth the effort!!! I have never eaten any Cubes that were as VISUAL as these are. Not to mention a little goes a LONG ways. Gram and a half of these little fellers will blister your brain!"
Psilocybin and psilocin are part of the tryptamine family. Their chemical structure bears close resemblance to that of serotonin.
All Panaeolus species contain the neurotransmitter serotonin.
Cubensis and wood lovers do not contain serotonin. The primary effect of psilocin is on the receptors for serotonin and there is evidence that psilocybin reduces the reuptake of serotonin by neurons in the brain allowing this neurotransmitter more time to act in the synapse.
"The occurrence of tryptamine derivatives in Panaeolus cyanescens, also known as Copelandia cyanescens, from Australia, Hawaii and Thailand were investigated. All 70 collections contained psilocin, serotonin and urea. Those from Hawaii were also relatively rich in psilocybin, whereas the species from Australia and Thailand were virtually exempt of this compound.
It is not unthinkable that the ability to biosynthesize psilocin in a number of Panaeolus is a consequece of a genetic accident: initially, these members of the genus probably produced more or important qualites of serotonin until a mutation conferred the ability to produce 4-hydroxylated tryptamines. So far, not other genus or species has been found to accomplish this feat!"
Partial reference from:
Stijve, T. (1992): Psilocin, psilocybin, serotonin and urea in Panaeolus cyanescens from various origin
Even with lower levels of psilocybin, Panaeolus are still more potent than Cubensis. Why?
Because by weight psilocin is around 1.4 times more potent than psilocybin.
The primary active ingredients of psilocybe mushrooms are psilocybin and psilocin, and to a lesser extent baeocystin and norbaeocystin. The ratio of psilocybin to psilocin varies from species to species. The primary difference is that psilocin is unstable and it breaks down in the presence of oxygen. If the mushrooms are dried correctly and kept cold, they should suffer very little psilocin break down. Psilocybin on the other hand has been found in a 115-year old mushroom sample.
It is believed that after injestion, psilocybin is easily converted into psilocin and that the pharmacological properties of both compounds are the same.