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Dissociatives The Big & Dandy 3-MeO-PCE Thread

I start outpatient in a couple of weeks because I got my 3rd DUI 2 weeks ago with multiple possession charges. Lost over a grand in drugs to the cops. I’m going fucking hard til then.
 
Is there no 3-ho-pce mega thread? Well, I just got a sample of that my gram of the MEO this coming. Popped 10 mg of 3-ho-pce with lil amphetamine sulfate. Feeling good. Oral is def better. I would always snort it. Think the amine group is more effectively metabolized orally. It’s like a mix between 3-meo-pce and 3-ho-pcp.
 
Finally got my g of 3-meo-pce today. I’m too drunk and coked out to even think about touching it. Thankfully I don’t have any needles around because when I get going I want to take it all the way.

Either tomorrow or the next day I plan on combining lsd, MDA, 4-ho-mipt, and 3-meo-pce. I’m doing my last pull on my MHRB solution and hope to get enough for a couple blast offs. I recall a similar combo except there was no mipt and I had 3-ho-pcp instead. I was able to explore hyperspace for a good 20-30 min.
 
On closer examination I checked my own vital signs and note that 3-MeO PCE significantly increased my blood-pressure, heart rate and respiration rate.

I note that as well as NMDA and DAT activity, 3-MeO PCE also has significant α2A adrenoceptor affinity. This is the same as cocaine.

I am entirely unsurprised that even without a person consuming other compounds, we have seen fatalities attributed to '3-MeO PCE Intoxication'.
 
4DQSAR said:
On closer examination I checked my own vital signs and note that 3-MeO PCE significantly increased my blood-pressure, heart rate and respiration rate.

I note that as well as NMDA and DAT activity, 3-MeO PCE also has significant α2A adrenoceptor affinity. This is the same as cocaine.

I am entirely unsurprised that even without a person consuming other compounds, we have seen fatalities attributed to '3-MeO PCE Intoxication'.
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I never took my heart rate while consuming 3-MeO-PCE so I don't have exact numbers to back it up, but that was the red flag for me with that compound. There would be times where my heart rate and BP felt like it got real wonky out of nowhere. At times it was a bit concerning and I'd have to take a clonidine.

It can be a great compound when used in moderation but it is not a chemical suited for binging
 
4DQSAR said:
On closer examination I checked my own vital signs and note that 3-MeO PCE significantly increased my blood-pressure, heart rate and respiration rate.

I note that as well as NMDA and DAT activity, 3-MeO PCE also has significant α2A adrenoceptor affinity. This is the same as cocaine.

I am entirely unsurprised that even without a person consuming other compounds, we have seen fatalities attributed to '3-MeO PCE Intoxication'.
Click to expand...
Yeah it def does more so than 3-ho-pcp or even 3-ho-pce and I tend to combine it with amphetamines. Well today it’s been 3 hits of lsd throughout the day, sniffed rest of my 4-ho-mipt, 12mg or so 3–meo-pce, bumps of amphetamine sulfate, and a mix of low doses of etiz, flualp, and bromoethylazolam, oh and 200mg of Lyrica. Thankfully, I have loads of clonidine as well
 
Bummed I’m out of dmt. Got about 1.2 g of dmt via stb from 100g bark. I did it with missing equipment so not too bad but damn I miss it. One psychedelic I could do and it never gives me a bad trip.
 
higherconciousness said:
Yeah it def does more so than 3-ho-pcp or even 3-ho-pce and I tend to combine it with amphetamines. Well today it’s been 3 hits of lsd throughout the day, sniffed rest of my 4-ho-mipt, 12mg or so 3–meo-pce, bumps of amphetamine sulfate, and a mix of low doses of etiz, flualp, and bromoethylazolam, oh and 200mg of Lyrica. Thankfully, I have loads of clonidine as well
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Yeah - be very careful when mixing up all those things. I mean, I know doctors only flag single interactions so heavens alone knows what the potential interactions that could be going on with all that.

Don't want to see your name in the Bluelight Shrine. Take good care of yourself.
 
higherconciousness said:
Yeah it def does more so than 3-ho-pcp or even 3-ho-pce and I tend to combine it with amphetamines. Well today it’s been 3 hits of lsd throughout the day, sniffed rest of my 4-ho-mipt, 12mg or so 3–meo-pce, bumps of amphetamine sulfate, and a mix of low doses of etiz, flualp, and bromoethylazolam, oh and 200mg of Lyrica. Thankfully, I have loads of clonidine as well
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That is a hell of a combo. Good thing you aren't driving lol. It does sound fun. Never been one to mix stimulants with psychedelics but I can see it being fun with benzos
 
SuperPsych said:
That is a hell of a combo. Good thing you aren't driving lol. It does sound fun. Never been one to mix stimulants with psychedelics but I can see it being fun with benzos
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I have quite a tolerance to amphetamines and I find it less taxing than taking MDA or some other compound in that family. The 3-meo-pce seems to complicate things more than anything in regards to heart rate, but as long as the dose isn’t too high it seems manageable. The benzos and clonidine seem to offset any side effects produced by such a mix as well.

Just woke up and took 50mg 2-FMA as I’m out of my normal amp sulfate. May take 12 mg of 3-meo-pce. As long as it’s used within reasonable doses it’s a great substance, but over that threshold is crossed it can get messy. This one is to be used with extreme caution more so than the others. Getting quite pricey lately but a g should last one quite some time.
 
higherconciousness said:
I have quite a tolerance to amphetamines and I find it less taxing than taking MDA or some other compound in that family. The 3-meo-pce seems to complicate things more than anything in regards to heart rate, but as long as the dose isn’t too high it seems manageable. The benzos and clonidine seem to offset any side effects produced by such a mix as well.

Just woke up and took 50mg 2-FMA as I’m out of my normal amp sulfate. May take 12 mg of 3-meo-pce. As long as it’s used within reasonable doses it’s a great substance, but over that threshold is crossed it can get messy. This one is to be used with extreme caution more so than the others. Getting quite pricey lately but a g should last one quite some time.
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I suggest to you that while your consciousness may become tolerant to certain compounds, it's in no way certain that the body will equally evolve tolerance.

3-MeO PCP is a high risk compound in my experience. I've just spent the last week exploring it until last night I didn't sleep a wink and even moderate exercise showed that my vital signs were still elevated some 18 hours after the last dose.

So I've put it down for a while. I don't like stimulants but it appears that 3-MeO PCE produces diminishing returns in terms of pseudopsychedelic effects and essentially you are left with a long-acting nasty stimulant. Not as bad as desoxypipradrol, but still pretty bad. Why not the much safer (based on very little proper in vivo testing) CMXE (2-(2-chloro-5-methoxyphenyl)-2-(ethylamino)cyclohexan-1-one)? I presume because although more potent than K, it's more akin to K than to PCP derivatives thus less potent and shorter acting.

BTW if someone really feels it VITAL to produce a pure stumulant based on the ACA (aryl cyclohexylamine) class, benocyclizine (BTPC) briefly turned up as an RC and as with 3-MeO PCP, the dose/response curve is steep, the duration long and it would appear that consumers avoided it in droves. It ended up being sold in fake MDMA tablets. What does that tell us? Just because we can doesn't mean we should, I suspect.
 
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I read an article, granted a single article, on mice claiming,

“Agmatine potentiates antidepressant and synaptic actions of ketamine: Effects on dendritic arbors and spines architecture and Akt/S6 kinase signaling”​


I’m wondering if the combination of agmatine and low doses of 3-meo-pce could potentially exert some of the same effects. This is highly speculative of me and perhaps I’m out of my depth here because 3-meo-pce is a whole other beast when compared to ketamine, yet it’s still an NMDA antagonist. The article purposes that the combination of agmatine resulted an increase in the post formation of dendritic spines, leading to a higher number of dendrites formed.

 
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