The Big & Dandy 25I-NBOMe Thread (2nd edition)

[JaneDoe2290]

Be careful taking this one a lot. It is a full agonist and it some ways I don't feel it's really meant for human ingestion, somewhat similar in nature to synthetic cannabinoids.

Then again, it has produced some very beautiful experiences for me.

Why do you say this? Have you noticed something that would be cause for concern? I don't understand why that's a big deal, but I suppose I'm fairly ignorant on the subject.

 

[zn13bt]

I was really hoping for the convenient storage of a blotter...but I'll do whatever I have to do I guess. If you guys could maybe suggest something that'd be great - but it looks like a lot of people are having the same trouble as I am.

You could keep it in solution and only prepare a single blotter just before you want to take it, or you could divide up the 16 pieces of blotter and put them in 16 individual trays to dry them in. It's a little more work, but at least there won't be an issue of them drying unevenly.

Counting drops isn't really an accurate method of measurement...do you have an oral syringe or something along those lines?

 

[IamMe90]

Why do you say this? Have you noticed something that would be cause for concern? I don't understand why that's a big deal, but I suppose I'm fairly ignorant on the subject.

Well, when you look at the cannabinoids, the synthetics tend to have more long term and short term undesirable side effects and have resulted in a lot more trouble for a lot of people than marijuana, and they are full cb1 agonists (the alkaloids in marijuana are not). Most of the 5ht2a psychedelics on the market (LSD, mushrooms, 2c-x, etc) are partial agonists - the only full agonists I know of are DOI and 25i, but I bet there are more. I don't know how full agonism affects the body, but it's something that I don't think happens naturally.

 

[sn23]

That strongly depends on the experiment: if a compound's efficacy is assayed against the natural ligand and turns out to be 100%, then it is as full an agonist as the natural ligand is (with the natural ligand as the full agonist, per definition).

But it is possible that full agonists (and partial agonists, for that matter) activate second messenger pathways in different proportions which could lead to markedly different biological effects. Therefore compounds should be evaluated individually, and not only one pharmacological parameter taken into account.

 

[uncle_bud]

Hi everyone

Here to share my technique of preparing 25i as when i started i run in to a couple of problems with solubility, but now i managed it perfectly
and found a really good way for nasal drops.

1. i get a bottle (10ml )

2. I weight out 20mg of 25Inbome and put it the plastic bottle.
3. i add with a syring 10ml of water
4. add 3 drops of lemon juice
5. after 4 min of shaking there are no visible parts left.

So i have calculated that 1ml is aprox. 20 drops ... so 1 drop is aprox. 80-90uq

I would also like to add that i noticed many people don't handle 25I as well as other NBOMES ... i mean there we couple of people who ended up in hospital after 300-500uq, srceaming and totaly psycohotic.

Also how long can i expect 25i to not loose any potency if it is dry and stored in dark and cool place ?
I am sorry if i missed some info
Thank you

 

[NWE1122]

do you have an oral syringe or something along those lines?

No, but I could get one for $3 :]

Thanks for the tips. I got a tip from another friend to dissolve it in sweet breath drops like LSD comes sometimes. Thats a thought. I'd much much prefer something physical to put them on (sugar or blotter) but I'll do whatever I need to

Edit: @above poster - where have you read about people having difficult experiences from such a small dose? Everything I read had people freaking out only on really large doses.

 

[uncle_bud]

I have seen some of the episodes. I dont think that this happens becaose of the dose ... almost in all cases they started behaving odd couple of hours after the dosing ....

what i think is that especially 25I affects certain parts of the body and it bring's out any hidden mental conditions ... but i could be wrong
with 25C there were no such occurances even with 1mg + dosages ...

 

[NWE1122]

I have seen some of the episodes. I dont think that this happens becaose of the dose ... almost in all cases they started behaving odd couple of hours after the dosing ....

what i think is that especially 25I affects certain parts of the body and it bring's out any hidden mental conditions ... but i could be wrong
with 25C there were no such occurances even with 1mg + dosages ...

That can be said about any drug though.

 

[OZMANCOMETH]

I don't understand, 1mg. 25-I is pretty awesome, but, out of curiosity 125 uq. of 25-I has the same come up for me, in fact since the first time i tried this molecule, it actually seems like its potentiating its own effects? I took a 45 min. nap the other day that included lots of colorful fractals and i hadnt dosed in a few weeks... beginning to wonder about NBOMe's? wonder about the long term effects..... hmmmn....

 

[RR16]

After doing 5mg during 12 hour period I noticed my big toes were blue and pale. Anyone heard/experienced anything similar? I have heard high doses of Bromo can lead to loss of toes and fingers.

 

[jaurk]

That is seriously dangerous ^ I have not noticed that.

 

[cannibalsnail]

The Nbomes are EXTREMELY vasoconstricting. Worse than any stimulant or psychedelic I've tried. Weed is a mild vasodilator, as is capsaicn (in chillis)

 

[OZMANCOMETH]

rr16,
I am not sure about vasoconstrictor properties of NBOMe's, but, i was a Anesthesia tech for almost 20 yr.s, I am familiar with the effects of ergotamine bitartrate and ergotamine maleate, we used this in obststrics the slow bleeding, retained placentas, i have seen bluing of the extremites with ergot alkaloids, you sure it wasnt bad batch of LSCrazzzy?

 

[Tabtastic]

*snip* I know the ratio is 9g hpbcd: 1g 25i but does anyone know what the grain alcohol ratio should be in that scenario? Thanks.

 

[dextrous]

*snip* I know the ratio is 9g hpbcd: 1g 25i but does anyone know what the grain alcohol ratio should be in that scenario? Thanks.

THe grain alcohol ratio entirely depends on

1) how many mL your paper (assuming ur dropping on blotter) can absorb

 

[Section813]

Ive asked this several times without an answer. Assuming the ratio above and blotter being able to hold 1mg of material per square doesnt this mean you could only lay 100mcgs per square?

 

[tregar]

I've been using 10mg doses of 4-aco-dmt along with super sub-threshold doses of 25i-nbome (50 mcg, yes less than 100mcg)...for amazing trips...very similar to low doses of acid (100ug)....music sounds incredible, so good in fact that I spend hours of each trip just listening to new music, it is very mystical, euphoric, mind-manifesting, jeweled dmt-like visuals, incredibly colorful and emotional, i enjoy 450mg of mescaline all by itself once a month, but take these mini-4-aco-dmt combined with 25i trips at different time of the month to enjoy music for many hours, things become "new and exciting" just like with acid or dmt, A+ experience, top notch.

a warning to be careful to not allow the 25i-nbome to be very high or else vasoconstriction might could set in to some degree...I had better explain the importance of the 4-aco-dmt to remain a good dosage and why i believe the 25i dosage should be extremely light...

Mixing in only 50mcg of 25i-nbome with the 10mg of 4-aco-dmt allows the 4-aco-dmt to be the star of the show, the 5-ht2A agonism from the 25i-nbome is never allowed to "overpower" the more important 5-ht1a, 5-ht1e, 5-ht1d, 5-ht7, 5-ht6, receptor agonism provided by the 4-aco-dmt. this allows "serotonin firing" to still be shut down by the 4-aco-dmt, which in turn allows the 4-aco-dmt molecule to act as a replacement for serotonin, LSD and mescaline also shut down serotonin firing....this happens because they too only allow 5-ht2a agonism to remain very low on the scale of receptor agonism, allowing 5-ht7, 5-ht6, 5-ht1a, d, e, etc. to remain the star of the show, this is needed for a spiritual mystical experience...these 7, 6, and 1 receptors make up over 80% of the brain's receptors, and they shouldn't be overpowered by 5-ht2a agonism (from the 25i-nbome) or else you end up with trips given by synthetics like 2c-e, DOI, DOC, DOM, 2c-i, etc. etc.

these natural psychedelics including the semi-synthetic LSD are precise molecular keys which all hit the more important 5-ht1a, e, and 7, 6 receptors with greater force than 5-ht2a...whereas if you study the synthetics made by man they all allow 5-ht2a to overpower everthing else, which gives visual psychedelics with little to no spiritual meaning, and meaning-less visuals, ridiculous or empty types of mental states with no spiritual significance, no archaic or meaningful visuals, etc. What I am doing with the 25i-nbome is allowing the 5-ht2a to rise only so very slightly so that it does not overpower the other important receptors that 4-aco-dmt hits, similar to LSD which allows 5-ht2a agonism to be only "8th in line" behind other more important brain receptors which make up most of the brain. I've studied Ray's receptor project data for several months, it all makes sense when you compare the classic psychedelics to the synthetics.

The tiny amount of 25i-nbome that I used only "lit up" the 4-aco-dmt workspace similar to how LSD does the same with all the other receptors before it in strength. It is a remarkable experience very similar to acid in effects, so similar in that it is mystical, brightly lit work space, euphoric, very spiritual, completely able to move around and not be sedated by the 4-aco-dmt, very emotional and colorful, with meaningful visuals and thoughts, 100% mind-manifesting. If the 25i-nbome becomes too high however (above 100ug or so)...then the quality of the trip dramatically deteriorates as the 25i-nbome 5-ht2a agonism overpowers the importance of the 4-aco-dmt...becoming nothing more than a synthetic poor quality trip.

 

[tregar]

Yes, 25i-nbome is very vasoconstrictive, that is the nature of 5-ht2a agonism, which is stimulating and vasoconstricting...25i-nbome is one hundred times more powerful at the 5-ht2a site then even Acid is (see Nichols paper on 25i-nbome and pea's where he states this fact of potency). I've read reports of people taking near 1mg and not being able to move very much, remaining motionless with cold feet and hands, I can't imagine what it might do to the brain at these levels, quite possibly trigger vasoconstriction in the brain on the left and right sides to some degree.

 

[IamMe90]

I've been using 10mg doses of 4-aco-dmt along with super sub-threshold doses of 25i-nbome (50 mcg, yes less than 100mcg)...for amazing trips...very similar to low doses of acid (100ug)....music sounds incredible, so good in fact that I spend hours of each trip just listening to new music, it is very mystical, euphoric, mind-manifesting, jeweled dmt-like visuals, incredibly colorful and emotional, i enjoy 450mg of mescaline all by itself once a month, but take these mini-4-aco-dmt combined with 25i trips at different time of the month to enjoy music for many hours, things become "new and exciting" just like with acid or dmt, A+ experience, top notch.

a warning to be careful to not allow the 25i-nbome to be very high or else vasoconstriction might could set in to some degree...I had better explain the importance of the 4-aco-dmt to remain a good dosage and why i believe the 25i dosage should be extremely light...

Mixing in only 50mcg of 25i-nbome with the 10mg of 4-aco-dmt allows the 4-aco-dmt to be the star of the show, the 5-ht2A agonism from the 25i-nbome is never allowed to "overpower" the more important 5-ht1a, 5-ht1e, 5-ht1d, 5-ht7, 5-ht6, receptor agonism provided by the 4-aco-dmt. this allows "serotonin firing" to still be shut down by the 4-aco-dmt, which in turn allows the 4-aco-dmt molecule to act as a replacement for serotonin, LSD and mescaline also shut down serotonin firing....this happens because they too only allow 5-ht2a agonism to remain very low on the scale of receptor agonism, allowing 5-ht7, 5-ht6, 5-ht1a, d, e, etc. to remain the star of the show, this is needed for a spiritual mystical experience...these 7, 6, and 1 receptors make up over 80% of the brain's receptors, and they shouldn't be overpowered by 5-ht2a agonism (from the 25i-nbome) or else you end up with trips given by synthetics like 2c-e, DOI, DOC, DOM, 2c-i, etc. etc.

these natural psychedelics including the semi-synthetic LSD are precise molecular keys which all hit the more important 5-ht1a, e, and 7, 6 receptors with greater force than 5-ht2a...whereas if you study the synthetics made by man they all allow 5-ht2a to overpower everthing else, which gives visual psychedelics with little to no spiritual meaning, and meaning-less visuals, ridiculous or empty types of mental states with no spiritual significance, no archaic or meaningful visuals, etc. What I am doing with the 25i-nbome is allowing the 5-ht2a to rise only so very slightly so that it does not overpower the other important receptors that 4-aco-dmt hits, similar to LSD which allows 5-ht2a agonism to be only "8th in line" behind other more important brain receptors which make up most of the brain. I've studied Ray's receptor project data for several months, it all makes sense when you compare the classic psychedelics to the synthetics.

The tiny amount of 25i-nbome that I used only "lit up" the 4-aco-dmt workspace similar to how LSD does the same with all the other receptors before it in strength. It is a remarkable experience very similar to acid in effects, so similar in that it is mystical, brightly lit work space, euphoric, very spiritual, completely able to move around and not be sedated by the 4-aco-dmt, very emotional and colorful, with meaningful visuals and thoughts, 100% mind-manifesting. If the 25i-nbome becomes too high however (above 100ug or so)...then the quality of the trip dramatically deteriorates as the 25i-nbome 5-ht2a agonism overpowers the importance of the 4-aco-dmt...becoming nothing more than a synthetic poor quality trip.

Do you really think 2c-e and DOM are objectively, or even statistically "shallow" trips? If so, then I have to say, I really can't put any stock into your theory since they are obvious examples of chems not hitting the apparently crucial receptor systems involved in mystic experiences, that are most definitely not shallow.

 

[crOOk]

I've been using 10mg doses of 4-aco-dmt along with super sub-threshold doses of 25i-nbome (50 mcg, yes less than 100mcg)...for amazing trips...very similar to low doses of acid (100ug)....music sounds incredible, so good in fact that I spend hours of each trip just listening to new music, it is very mystical, euphoric, mind-manifesting, jeweled dmt-like visuals, incredibly colorful and emotional, i enjoy 450mg of mescaline all by itself once a month, but take these mini-4-aco-dmt combined with 25i trips at different time of the month to enjoy music for many hours, things become "new and exciting" just like with acid or dmt, A+ experience, top notch.

a warning to be careful to not allow the 25i-nbome to be very high or else vasoconstriction might could set in to some degree...I had better explain the importance of the 4-aco-dmt to remain a good dosage and why i believe the 25i dosage should be extremely light...

Mixing in only 50mcg of 25i-nbome with the 10mg of 4-aco-dmt allows the 4-aco-dmt to be the star of the show, the 5-ht2A agonism from the 25i-nbome is never allowed to "overpower" the more important 5-ht1a, 5-ht1e, 5-ht1d, 5-ht7, 5-ht6, receptor agonism provided by the 4-aco-dmt. this allows "serotonin firing" to still be shut down by the 4-aco-dmt, which in turn allows the 4-aco-dmt molecule to act as a replacement for serotonin, LSD and mescaline also shut down serotonin firing....this happens because they too only allow 5-ht2a agonism to remain very low on the scale of receptor agonism, allowing 5-ht7, 5-ht6, 5-ht1a, d, e, etc. to remain the star of the show, this is needed for a spiritual mystical experience...these 7, 6, and 1 receptors make up over 80% of the brain's receptors, and they shouldn't be overpowered by 5-ht2a agonism (from the 25i-nbome) or else you end up with trips given by synthetics like 2c-e, DOI, DOC, DOM, 2c-i, etc. etc.

these natural psychedelics including the semi-synthetic LSD are precise molecular keys which all hit the more important 5-ht1a, e, and 7, 6 receptors with greater force than 5-ht2a...whereas if you study the synthetics made by man they all allow 5-ht2a to overpower everthing else, which gives visual psychedelics with little to no spiritual meaning, and meaning-less visuals, ridiculous or empty types of mental states with no spiritual significance, no archaic or meaningful visuals, etc. What I am doing with the 25i-nbome is allowing the 5-ht2a to rise only so very slightly so that it does not overpower the other important receptors that 4-aco-dmt hits, similar to LSD which allows 5-ht2a agonism to be only "8th in line" behind other more important brain receptors which make up most of the brain. I've studied Ray's receptor project data for several months, it all makes sense when you compare the classic psychedelics to the synthetics.

The tiny amount of 25i-nbome that I used only "lit up" the 4-aco-dmt workspace similar to how LSD does the same with all the other receptors before it in strength. It is a remarkable experience very similar to acid in effects, so similar in that it is mystical, brightly lit work space, euphoric, very spiritual, completely able to move around and not be sedated by the 4-aco-dmt, very emotional and colorful, with meaningful visuals and thoughts, 100% mind-manifesting. If the 25i-nbome becomes too high however (above 100ug or so)...then the quality of the trip dramatically deteriorates as the 25i-nbome 5-ht2a agonism overpowers the importance of the 4-aco-dmt...becoming nothing more than a synthetic poor quality trip.

my own acid experiences were never mystical or spiritual. i surely laffed a lot and enjoyed myself thoroughly, but it never was spiritual in my case. out of 100s of experiences, only a few were so deeply spiritual that they brought upon me lasting changes in my understanding of life and death. DOC was such a compound, DMT the other. Other trips usually often felt spiritual and brought a sense of closeness to god, a sense of unity and i always sought that feeling, that mind space. but the 6 (?) times i did acid never were anything like that, they were mostly just extremely humorous and romantic.

im not entirely disagreeing to what you say, you might be onto something there... its just that every trip is an experience of its own and experiences induced by the same substance can vary greater than two experiences made with different substances i guess.

oh and 2ce totally isnt shallow either, it is pure fucking magic to me. one of the most rewarding psychedelics i know of despite my tendency to puke every 10 minutes while on it.

btw isnt the 5ht2a receptor the one associated with malignant hyperthermia?