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Phenethylamines The Big & Dandy 25E-NBOMe Thread

Yes Its more potent than 25D . I need 1,5 mg - 2mg 25D for strong +++ , 800 mcg 25E gives me good +++ , mindfuck is similar to 2C-E , colours was very dark not like 2C-E when you see palette of colours , OEV and CEVs was similar but differed slightly .
I'm not a fan of 2C-E so this compound had not impress me , but I think that
A lot of people may like this substance
And I didnt notice strong synesthesia like after 2C-E
 
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Cloudy said:
So the steric hindrance is going to decrease the efficiency and affinity at the receptor sites? Considering the energy to bind to the receptors under such conditions I'd imagine they wouldn't as readily bind nor stay binded for very long, contributing to a lower potency at the receptors.
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skillet said:
The N-benzyl portion fits into a different part of the receptor, it might cause the phenethylamine portion to be shifted over slightly, but not a great deal. Maybe there will be slightly less tolerance for bulky 4-substituents in the N-benzyl derivatives, but I doubt ethyl would be too big.

Edit: As psykap wrote, it's not. I guess that's more potent than 25D?
Click to expand...

Would there be less pharmacodynamic tolerance than with other (less bulky) NBOMe derivatives?
 
isnt there a 2-furanyl derivitive (that would be smaller.. and according to the theory so far presented in this thread allow for bulkier 4 groups) that was more potent than the other drugs?
i think nuke had something on it in one of the threads from 08'
 
There is, think it's in Bradens thesis. But it has about 8x lower affinity than 25I-NBOMe.
 
any info regarding the preffered ROA for this chem? I suspect they are the same as with the other 25 (insufflated and sublingual, maybe rectal)?

what about the timeline of the drug?
 
I think the timeline of these NBOMe analogues is mostly the same because when the NBOMe group is metabolized, what is left is the 2C-X counterpart in quantities to low to sustain the psychedelic effects.
One reason I have to believe this is because 25G-NBOMe seems to last virtually as long as 25C-NBOme, even though 2C-G is one of the most long lasting 2C-Xs there are and 2C-C one of the shortest acting ones.
 
if anyone could compare it to 25C that would be helpful. :D

I'm particularly interested if it seems more qualitatively "deep" than 25C, though visual & bodyload comparisons would be nice as well.

Any similar cardiovascular effects or headache the following day?
 
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25E got much similarites to 2C-E , bodyload is very hardly , muscle tension ,lockjaw . OEVs are very similar to higher doses 2C-E but I didnt notcied synesthesia , The deep is also very similar .A s for me is much less euphoric than 25C
At the moment it is the worst NBOMe with which I worked but it could be cause this that I dont like 2C-E :)

Duration : max 5h
 
For me bodyload was the same as 25C- almost none. It was less "stoning" than 25C, it was more profound at the same time. Colours were beautiful, interesting OEVs and CEVs. And some really nice insight/introspection and unexpected spiritual experiences.

dose: 990ug
 
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i have a quick question regarding all of the NBOMe's actually, but since i really like 2C-E ill ask it here. I'm not too knowledgeable in the way psychedelics work on a chemistry standpoint, so bare with me.
when combining LSD and 2c-e it says on here that its best to take the 2c-e first not only so they peak at the same time, but because LSD has a higher affinity so it will out compete the 2c-e. now this chem has a much shorter duration no? so it'd be better to dose LSD first if combining. since the NBOMe's have a much higher affinity than the 2c's, would they be able to hold their own against LSD, or is the affinity still too low for it to be affective?
i hope i made sense there lol.
 
The N-benzyl PEAs (of which the NBOMe compounds are a subset of) have affinities comparable to LSD, with the simple 4-halo NBOMe compounds (ie. NBOMe-2C-C/B/I) having higher affinities than LSD proper (but still being lower subjective potency by weight).

Yes, I would take the LSD first. Maybe take the NBOMe compound an hour or two into the trip.

Be aware that because some of the NBOMe compounds DO have a higher affinity than LSD that they might actually decrease the intensity of the trip. Whether they do or not depends entirely on what compound is used in particular. This is because they may displace LSD at the receptors in question, whilst having a lower efficacy at the receptor - similar in concept to how 5-HT2A antagonist antipsychotic drugs can terminate a trip by displacing the original drug but having no activity at the receptor. I have a feeling that NBOMe-2C-D might do this, for instance, but it's hard to say because as far as i'm aware, this is no published binding data for NBOMe-2C-D.
 
well that goes for the 5ht-2a receptor... if it is displaced from this one wouldnt it be more likely to bind to the plethora of other receptors it is known to bind to? therefore intensifying the lsd aspects of the trip while letting the 25 do its job propor?
 
Yeah, could do, though that could be either positive or negative, depends what qualitative aspects of the LSD (which contrary to popular belief is not a clean drug AT ALL) trip are attributable to what binding location really.
 
Got around to trying this a few weeks ago. Vaporized ~500µg. Definitely an interesting experience. Was a bit apprehensive that the come-up would be overly intense, but it wasn't bad at all. I suppose i was primed for the DMT-like rush i associate with that pipe ;) but there was an actual comeup. Granted it was rather fast, but smooth & not uncomfortable. I definitely feel like 25E retains more characteristics of the parent compound than does 25C. Should probably hold off judgement on that for a bit as i've only taken 25E once thus far, and I've taken 25C a few times, but always sublingual, so i'm sure that contributed to the differences i experienced as well.
 
Btw - sublingual is fail ROA for NBOMe's

For 25E experience, I can reccomend you 1 mg (buccal ROA). With 990ug I've had no negative body load at all.

And visuals were very unique (dancing room, Alex Grey vision when looking at myself in the mirror or at my friend)
 
Have been experimenting with several doses of 25i-nbome, the HPBCD-complexed 500ug of 25-inbome applied buccally to upper gum for 30 minutes blew the researchers mind it was so awesome, favorite psychedelic now, and have taken acid hundreds of times. I highly suggest complexing it with hpbcd then put on upper gum for 20 minutes for 95 percent absorption:

see post #61:
http://www.bluelight.ru/vb/threads/...cy-25I-NBOMe-Thread/page3?highlight=25i-nbome

Posted instructions for complexing in the big & dandy 25c-nbome thread, and quoted past research from Dr. Joseph Pitha that proves 95% absorption of hydrophobic drugs sublingually/bucally in 20 minutes. In my experience, hydroxy-propyl-beta-cyclodextrin complexed 25i-nbome applied buccally gives the exact same potency as nasally administered 25i-nbome, equipotent, whereas normally buccally applied non-complexed 25i-nbome gives only approximately 50% or so absorption. Complex this stuff, you don't know what you are missing, ease of ROA, great cost savings and significantly improved effectiveness.

This is why I find the 25i-nbome so magical:

* It has the same glowing deep shining empathogenic quality that acid has
* It shares much of the same headspace as acid, as well as the good-humor.
* It has the best non-mdma induced euphoria for the entire duration of the trip
* It is visually more spectacular than acid in it's own way, ie the OEV & CEV of DOI.
* Zero to very little anxiety potential
* reminds me of the time I took acid and mescaline together.
* Music sounds fantastic & is emotionally deep.
* Great therapeutic potential, helps in working through issues & problems, deeply spiritual.
* This molecule is very special and imho is the best research to ever come down the pipeline, I give thanks to the Discoverer who discovered it many years ago.
 
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i've been contemplating using some surfactants for buccal dosing, but i'm really liking the ease of vaporizing at the moment, as i've worked out a pretty efficient & easy method for it. Gonna stick with that for a bit, but surfactants are definitely on the to do list... got a lotta things on that to do list ;)

I was thinking of going with 750µg (vaporised) next time. Most of the doses i'm seeing here are closer to 1mg, i'm assuming those are mostly for buccal/sublingual? I'd guess insufflated & vaporized would have pretty similar potencies, but am not sure. Anyone care to comment?
 
From what I know, multiplier for buccal ROA is 1.5-2x (for you to achieve the same effect as you would achieve by sniff)
 
Thanks for the various informations :D Oh, and earlier when i mentioned 25C, i tried sublingual first, buccal for the second two experiences. Buccal definitely is an improvement over sublingual, and i imagine even moreso when complexed with HPBCD or surfactants. Definitely something i'll look at when i've got a bit more material to play around with.

Had a second vaporized dose of 25E not too long ago, @ 750µg. Substantially more intense than the 500µg dose from about 6 weeks ago. Visually things were much stranger, and mentally i was on a totally different plane. With the 500µg dose i felt, for most of the experience, like i was on the cusp of something much more grand, and slightly wavered into that territory for a few minutes, but it was fleeting. I definitely had more anxiety on the 500µg dose as well, unsure if that was related to my utter unfamiliarity with the chemical & the total lack of reports of anyone vaporizing it, or if it was more just me undershooting the threshold for a true mystical/psychedelic experience. For a while on 750µg i totally lost my place in/became one with the universe, or perhaps just the tree outside the window through which i was staring as the sun came up. The branches began to spread & swirl & appeared to interact with one another, then i realized that these branches were neurons in some type of galactic or planetary brain and i became an action potential & was shot forth into the void. At that point language fails me, but definitely one of my most memorable experiences of late. Definitely experienced some "Absolute Unitary Being" or "Oceanic Boundlessness" depending on which terminology you prefer. If i go higher it will probably be in 25µg or 50µg increments as i experienced some (though not quite worrying) elevated HR/BP. This was mostly during the comedown, which i found a bit odd. Anyone got a putative pharmacodynamic reason for that?
 
Also, anyone stored this in solution for an extended period of time? I didn't notice any degradation in the 6 weeks between the 1st two experiences. I guess time will tell whenever i get around to having a third.
 
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