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The Big & Dandy 1P-LSD Thread, Volume 1

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^^yeah....thanks..so would you say a thermos wont cut it either?

AmoebicMagician!! Youve eaten so much of this stuff...can I ask you for your personal opinion on whether you belive from your experience that 1p is a prodrug? Im on the fence. As stated above...1p has a gentle glde down to normalcy whereas regular LSD ALWAYS leaves me frazzled and dare I say "tweaked out" for the latter hours of the comedown. This is often when people feel tired of tripping and being overstimmulated thus they pop a benzo. Ive brought up this phenomenon before. But David Nichols does a lecture on this; many LSD users report that the latter portion of the acid experience is when the dopaminergic activity really kicks in. I have not exoerienced this drawn out overstimulated come down with 1p. It more or less seems to wear off in a similar way as mushrooms. 1p also is seems to be cut short by about 2 hours for me. These are my only reasons to doubt the assertion that its a prodrug. It just doesnt fit the exact mold of a prodrug. It also is about 75% as visual as LSD and a bit more euphoric and easy to follow thoughts. Theres less looping and negative thought loops.
 
I wouldn't be surprised if it isn't a simple prodrug and some of it is able to pass through the BBB intact. It reminds me of when 4-AcO-DMT came out. The prevailing opinion before that was that the 4-AcO-tryptamines were simple prodrugs of their 4-HO-counterparts. But then 4-AcO-DMT proved to be so different for some people (myself included) from 4-HO-DMT that the theory was essentially debunked. Now I don't know that anyone considers the acetoxy esters to only be prodrugs of the hydroxies. Could be similar with this.

I will say I have taken it several times and I find it to be virtually indistinguishable from LSD, except it seems a bit slower to come on and the afterglow is not as nice (incidentally, I LOVE the latter stages of LSD, it makes me feel so good, and the feeling persists for at least a day. Then again I also love DOC for the same sort of reason).
 
interesting .....so is 4-aco proven to be a produg to 4-ho? Or does some of aco pass thru the BBB as you suggested might be the case with 1p?
 
Unless the LSD is ice cold. It's going to stay at that temp for a short while but will get hot....you have to have something cold in the cooler to keep it from getting hot....so if you ziplock the LSD and put in a mason jar and put that in the cooler with something frozen that won't melt I imagine it would keep it cool
 
put the blotters somewhere cool ie in a book, in clingfilm n behind phone cover or battery for trip out , get cool jumper n insulate it against warmth as well as cold....

it's be enough. sealed n out sun morning were fine, in pocket inside ciggys up to a n e in Spain n few days on ward\ then inbhotel so they'd been in heat 26-28degrees the second trip seemed less n it was double material...

I never used Togo anywhere without ten blotters in my phone, wed always forget then wed rememervn take old Nokia to bits n munch em. batteries didn't get as got back then tho...... maybe charge it, turn it off n turn it on day of trip, u can get 12x6 prob or similar amount I sure I'll be fine.

I'd try n space them out n not be afraid of adding an extra each day. or if ur going for longer than two three days have day off or eat few in day sunrise-sunset in one go n then leave ur brains to recover a bit
 
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al-laddin said:
^^yeah....thanks..so would you say a thermos wont cut it either?

AmoebicMagician!! Youve eaten so much of this stuff...can I ask you for your personal opinion on whether you belive from your experience that 1p is a prodrug? Im on the fence. As stated above...1p has a gentle glde down to normalcy whereas regular LSD ALWAYS leaves me frazzled and dare I say "tweaked out" for the latter hours of the comedown. This is often when people feel tired of tripping and being overstimmulated thus they pop a benzo. Ive brought up this phenomenon before. But David Nichols does a lecture on this; many LSD users report that the latter portion of the acid experience is when the dopaminergic activity really kicks in. I have not exoerienced this drawn out overstimulated come down with 1p. It more or less seems to wear off in a similar way as mushrooms. 1p also is seems to be cut short by about 2 hours for me. These are my only reasons to doubt the assertion that its a prodrug. It just doesnt fit the exact mold of a prodrug. It also is about 75% as visual as LSD and a bit more euphoric and easy to follow thoughts. Theres less looping and negative thought loops.
Click to expand...

I am of two minds on this for a few reasons:

Number one, the fact that I have partaken of incredible tabs that were dubbed 'bunk' by two SEPARATE friends the only connection for which was that both were on MAOIs

Secondly and seemingly in contrast, while prodrugs take some time to establish effects, while 1p-LSDs comeup is a little stagey and gradual, first alerts are MUCH quicker than with LSD-25, so some of it is either being broken down INCREDIBLY FAST by some unknown metabolic action, or it is passing the BBB intact and having at least some effect there while still in it's initial (and quite stable, BTW!) form.

Thirdly, this molecule stands up to heat and wet EXTREMELY WELL, much better than LSD-25. It does not seem to readily hydrolyze, which makes me wonder how easily it is being cloven in vivo.

As for the comedown, I am in total agreement that it is different and superior to LSD-25

At the tail end of higher dose LSD-classic experiences I will find myself, if not planning very well, sitting in bed trying to chase down the sand man, thinking weird trip thoughts long after the visuals and the fun part of the trip are over.

With 1p-LSD this is not only not the case due to dovetailing effects diminishment with the onset of normal headspace, but the fact that I can actually fall asleep without trouble at the tail end of these experiences. I don't know why, but I find myself inclined towards comfort and sedentary pursuits on this compound, although physical pursuits are just as rewarding as on LSD-25, I am not compelled to them via nervous energy.

And yes, I have been taking a lot of the stuff. I have found this one has the headspace of LSD and is capable of creating moments of infinity- something lacking from literally every single RC I had tried hoping to mimic LSD-classic. I had been looking for that beauty so long, that when I found it, and with no after-weirdness to boot, I was and am wont to over indulge.

I have found this drug makes a fine addition to other chemicals, as it provides a deep religious and spiritual facet to most any psychedelic experience- although it is not the most well rounded psychedelic on it's own for being slightly lacking in the visual department.

But as for the prodrug theory, I just can't say, too much contradictory data.

I do consider it a class A psychedelic though, and I do NOT give that status lightly

As for 4-aco-dmt for me personally it has been indistinguishable from the effects profile I get from psilocybe cubenesis minus the nausea.
 
al-laddin said:
This is it....fast forward to 43:00mins.. Its extremely interesting...this is an effect reported by MANY Ive talked to ...I wonder if 1p actually has different action. "Give me a valium, I want it to stop". https://www.youtube.com/watch?v=ZJtdZUy1LYE
Click to expand...

I am in absolute awe of Nichols. I can not believe how incredibly lucrative his research has become. In short, he is one of my heroes
 
al-laddin said:
This is it....fast forward to 43:00mins.. Its extremely interesting...this is an effect reported by MANY Ive talked to ...I wonder if 1p actually has different action. "Give me a valium, I want it to stop". https://www.youtube.com/watch?v=ZJtdZUy1LYE
Click to expand...

That's pretty interesting indeed, I have not tried 1P-LSD (I have some in my freezer but haven't got the time to test it yet :P) but if what you report is a replicable subjective effect, then maybe 1P-LSD isn't a simple prodrug, and maybe the propionyl is impairing the formation of hydroxy metabolite responsible for the Dopaminergic action of LSD that Nichols describes in the video
 
I don't buy the prodrug theory about 1p-LSD. For me the effect is different. Even if I never tried ALD-52, the effect of 1P seems closer to it according to the experience I red.
 
stanleyK said:
I don't buy the prodrug theory about 1p-LSD. For me the effect is different. Even if I never tried ALD-52, the effect of 1P seems closer to it according to the experience I red.
Click to expand...

agree whole heartedly about subjectively different experiences, but according to the docking mechanism we are subscribing to, the 1p will not be able to dock with the 5ht-2 serotonin receptor in it's original state. As is said in the lecture, the diethylamide structure of the lysergamide family is necessary for psychedelic effects profile to manifest, there is a tidbit of an idea here, but I can't grasp it right now.

All I know is that two things are undeniable in my mind

1p LSD is indeed active, and triggers the full range of psychedelic effects with proper dosage, and that it is for the vast majority of users lacking the dopaminergic secondary effects talked about in the video. Even initially, there is no or little teeth grinding or nervous habit energy as with it's big brother.

The thing is, since we know that MAOIs interact with the successful use of this drug, that DOES in fact state that in vivo the drug is not active as administered, it is metabolized into SOMETHING that is active, but not LSD-25
 
AmoebicMagician said:
agree whole heartedly about subjectively different experiences, but according to the docking mechanism we are subscribing to, the 1p will not be able to dock with the 5ht-2 serotonin receptor in it's original state. As is said in the lecture, the diethylamide structure of the lysergamide family is necessary for psychedelic effects profile to manifest, there is a tidbit of an idea here, but I can't grasp it right now.

All I know is that two things are undeniable in my mind

1p LSD is indeed active, and triggers the full range of psychedelic effects with proper dosage, and that it is for the vast majority of users lacking the dopaminergic secondary effects talked about in the video. Even initially, there is no or little teeth grinding or nervous habit energy as with it's big brother.

The thing is, since we know that MAOIs interact with the successful use of this drug, that DOES in fact state that in vivo the drug is not active as administered, it is metabolized into SOMETHING that is active, but not LSD-25
Click to expand...
And what about ALD-52?
 
AmoebicMagician said:
agree whole heartedly about subjectively different experiences, but according to the docking mechanism we are subscribing to, the 1p will not be able to dock with the 5ht-2 serotonin receptor in it's original state. As is said in the lecture, the diethylamide structure of the lysergamide family is necessary for psychedelic effects profile to manifest, there is a tidbit of an idea here, but I can't grasp it right now.
Click to expand...


I'm not sure why you are stating that 1P-LSD can't bind to the 5-HT receptors, but the diethylamide structure, which is essential for the pharmacological profile of LSD as explained in Nichol's talk is left completely unmodified in 1P-LSD. Just take a look at the molecule, the Propionyl is attached to the indole ring, not to the Diethyl (:

Really we can't say much without formal pharmacokinetic studies, but it's interesting to think that the propionyl group is able to block some enzymatic action on the indole moiety of LSD
 
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to be honest I can't even read that... but deck skills is an art I'm killer at n already said I'm tripping n expect n old school set
 
Img_9999 said:
I'm not sure why you are stating that 1P-LSD can't bind to the 5-HT receptors, but the diethylamide structure, which is essential for the pharmacological profile of LSD as explained in Nichol's talk is left completely unmodified in 1P-LSD. Just take a look at the molecule, the Propionyl is attached to the indole ring, not to the Diethyl (:

Really we can't say much without formal pharmacokinetic studies, but it's interesting to think that the propionyl group is able to block some enzymatic action on the indole moiety of LSD
Click to expand...

The diethylamide group is not the docking mechanism for the lysergamides, at least not for the serotonin receptors. When docked, however, the diethylamide group nest into a recess that we have no idea the evolutionary purpose of at this time- so while the diethylamide group seems to be necessary for activity in Lysergamides, that group is not the piece of the drug that binds to the receptors we believe are responsible for triggering the psychedelic condition

Edit:
Nichols has a short discourse on this subject where he explains why 1p-LSD can not bind as is, feel free to research this
 
nailed it 1p was pushingfaders psycomatically if nout else just took further 100mics n will knuckle down to the psy online stream I have, had few pints apres set but will knuckle down to me UV room 250 mics 1p n extra 100
I'm gonna enjoy doing my afters set to ppl who were telling me at urinals how trippy I was acting, even tho I was in public n dropping my last tune bk bootleg

viva los mal never again will i let u beforgot

avoid urine samples if ur benzo or lysergant as they'll for u to a bed serious if not for Mafia Peruvian soulmate I'd be in los lochos tillsomeone could d\c me

viva Antonia s n the cockey girl h helped me survive in Majorca lock up
 
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