• H&R Moderators: streaM Freak

The Big Buvidal Thread - Buprenorphine Extended Release Injection

Until now I had only read comments made by BLer based in NZ who bemoanded the fact that they had to fly to the clinic every month as it appeared only to be licenced by specialists in treatment of addiction so only a few clinics offered it.

I think the OP made a comment that just about explains it all. Every day is one long 'mission' just to stay well at the cost of all other activities and passtimes. In essence, people often struggle when provided substitution therapy as that everlasting mission was the only structure left within their lives.

I know Peter McDermot suggested looking at how much more money one has and doing all of the things that the drugs stopped you from doing. While eating an entire tub of Häagen-Dazs or going for a pedicure may not be for you, more than one client has suddenly become a massive reader. Maybe it's dog-eared copies of yet another book devoted to one topic but I would almost think they developed a reading addiction.

While the local HR provider do a pretty good job (in spite of every single client having a complaint), they do provide a drop-in centre open 9-5 weekdays. People would bring in DVDs and all would gather round and watch. I did feel it a slightly better option that essentially bribing clients with junkfood but then again, most clients had less fat on them than a whippet so maybe a fatso like me saw a risk where none existed. I have to admit that it does take quite a lot of observation to prevent it becoming a swap-shop of nicked goods, dealer hub and the various other things drop-in centres often struggle to manage. I think it worth paying someone to just be in the room - getting clean is hard, staying clean is harder.

I think if it works for the OP, that's the important bit.

NOT having to undergo supervised consumption and be kept waiting for 20 minutes MUST be a relief. In the UK, how pharmacists treat people on a daily pickup is more often nasty than kind. If I see someone doing so, I wish them well - self worth is worth a lot and a 'professional' should note that outside of that pickup, they know ZERO about a person's life.

IF you ever have a more technical question, please do not hesitate to PM me with any questions. I'm neither an oracle or a cypher so fallibility is possible but as always, I will try to provide hyperlinks to all of the scientific papers I can access on the basis that no faeries, gods or magic are involved - only science.
 
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I’m on the 96mg monthly of Brixadi and today at day 16 I’m having WD.
I had 6 weekly injections and got my first monthly a little over 2 weeks ago.
The cravings started on day 12 after the injection.
Is this normal?
Every weekly injection didn’t the full week.
I’m now on the monthly and it’s only been 2 weeks and it’s wearing off?
 
@rocknroller2 - I looked at the Brixadi website and noted it derives the dose from a false axiom.

Could I ask, were you previously prescribed sublingual buprenorphine and if so, what was that daily dose?

Because bioavailability of sublingual formulations can be anywhere from 30% to 55% so the Brixadiconversion chart is a nonsene. It derives the dose from a derived dose based on a false axiom i.e. that every patient demonstrates the same bioavailability of sublingual buprenorphine.

If the weekly dose didn't work, I'm sort of surprised that wasn't noted.

If you feel pushed, push back. If it doesn't work, tell a clinician because we all have to be the 'canary in the coalmine' for medications i.e. if clinicians THINK the depot injections work, they WILL support their usage. After all, the makers of Brixadi aren't going to tell clinicians the WHOLE truth.

I have read a dozen papers and you know what? Absolutely every one of them has authors who declared potential conflicts of interest. Most use questionnaires which is rational as after all it is the subjective wellbeing of the patient that is the important thing. But in not a single case was the questionnaire actually SHOWN.

Now you may wonder why that matters but it's long been known that questionnaires can be designed to give whatever result you seek.

Obviously this if a comedy example so extreme, but I hope you take the point that it's so very simple to manipulate the results based on the specific questions and even the order of questions.

 
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