atara
Bluelighter
Huh. Is this with the freebase or the hydrochloride? I have some lecithin and am willing to give it a go, but I'm not sure what to do...
Besides the structure of the chemical there are other things to affect it. Shelf life of each individual batch of any chemical depends on its purity. A purer batch lasts longer than the inpure one. The difference between them might be years for the pure batch against weeks for the impurest.Any idea on the longevity of this compound when in alcohol and/or water solution?
Asking because there are some reports of vastly diminished effects upon later dosing as confirmed by other first time users.
I would bet the issue was the fickle nature of sublingual administration, but it could be due to degradation.
The issues is actually their strong and long lasting tolerance to themselves and other NBOMes. There was a rumour some time ago that their cross-tolerance with other psychedelics like simple PEAs may actually be diminished. The person I heard that from made such conclusion based on a single experience of 4 people that were tripping together on NBOMe-2C-I and took 2C-B the next day. With some NBOMe, a strong dose taken the next day after the same or any other NBOMe is almost ineffective and produce very light effects.bluffythefluffy said:When I said later dosing I meant about a week - but it does seem like these substances could have pretty serious tolerance issues.
I don't think so. This compound, NBOMe-DOB, is both very weak and unpleasant. It even produce almost no usual visual phenomena of psychedelic phenylethylamines. Feels like being just stoned for a time without any use. The thing brings in some sensoric noize, blurs the vision, makes you feel like having flu (though not as awful as TMA-2 or 6 may feel), and goes away after several hours of such disgrace. The intensity of it's effects remain at plus 1 by the Shulgin scale no matter how much of it was ingested. 30 mg don't differ much in potency from 20 mg, or from 5 mg, increasing the dosage does almost nothing.ebola? said:Even the NBOMe-DOXs appear plenty potent enough to be just dandy (though less potent than the 'parent compounds', by an order of magnitude according to some reports).
The reversed order of potency of 2C-Hal-NBOMe should be viewed from a slightly different perspective to understand it. More lipophylic structures travel through the body and accumulate in the brain slower, than those that are less lipophylic. If we compare the amount of time between the intake and the peak seen in different NBOMe-2C-Hal, 3 hours for iodine and no more than 40 minutes for chlorine, it appears that they should actually be almost equipotent. The less hydrophobic NBOMe-2C-C reaches peak brain levels faster and thus seem like being more potent, NBOMe-2C-I travels through the body way slower and seem as if it is less potent.skillet said:I'm also guessing that the higher potency of the chloro analog over the bromo and iodo compounds is (at least partly) due to its lower lipophilicity, so I'd be very careful trying this with the other compounds, they could well be potentiated even more.
Theese peculiarities may possibly be related to another parameter describing interaction of the ligand with the receptor, the intrinsic activity. NBOMe-DOB has it somewhere around 20%, at the border between partial agonists and antagonists. NBOMe-2C-X intrinsic activity is normally as high as 70-80%, like that of DOX or some potent tryptamines. NBOMe-2C-I has the lowest of those that had been measured, 60+% if I remember it correctly. The numbers are available in Ralf Heim's work.
The reversed order of potency of 2C-Hal-NBOMe should be viewed from a slightly different perspective to understand it. More lipophylic structures travel through the body and accumulate in the brain slower, than those that are less lipophylic. If we compare the amount of time between the intake and the peak seen in different NBOMe-2C-Hal, 3 hours for iodine and no more than 40 minutes for chlorine, it appears that they should actually be almost equipotent. The less hydrophobic NBOMe-2C-C reaches peak brain levels faster and thus seem like being more potent, NBOMe-2C-I travels through the body way slower and seem as if it is less potent.
Huh. Is this with the freebase or the hydrochloride? I have some lecithin and am willing to give it a go, but I'm not sure what to do...
Oh, I should probably confirm the dosages involved, since this stuff is about to hit primetime it would seem, for better or for worse (probably worse, people can't seem to use the existing 2Cxs and DOxs responsibly!) ...
Insufflated: threshold ~ 100ug, +2 @ 250ug, +3 @ >400ug
Vapourised, as HCl salt (freebase sometimes shows signs of decomposition if vapourising): threshold ~ 30ug, +2 @ 50ug, +3 @ 150ug. Reduced duration. Favourite method for author.
Oral: no appreciable activity past 1mg, 'ceiling' level is reached, probably pharmacokinetic in origin.
Repeated dosing past the 1hr mark seems to only increase duration and return intensity to first dose levels, not beyond, probably a function of very rapid receptor downregulation.