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The Big and Dandy Ketamine Thread (Next iteration)

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euphoricnod said:
If one has an existing tolerance to psychedelics or MDMA will their tolerance to Ketamine be influenced?
In my experience, ketamine tolerance is not directly affected by tolerance to MDMA. I've gone through long periods of time taking only MDMA and building up a high tolerance to it, then taking K at the peak and still having low tolerance.

I've also taken K for long periods of time with (at separate time periods) heavy and sparse MDMA use, and found the tolerance buildup to K was largely the same.

This is based on what I've found; there's no science in there :)

Bare_head said:
I got a bit scared of A big dose.. though i still enjoyed it and it has remained with me more prominantly if you know what i mean
I think plenty of people are intimidated by higher doses of K, especially when they get this fear of a K-hole, or at least of full dissociation and extra dimensions. After doing larger doses a few times many people embrace that experience, since it's so powerful and not intimidating if you know what to expect.
 
euphoricnod said:
If one has an existing tolerance to psychedelics or MDMA will their tolerance to Ketamine be influenced?
I will carefully answer this. There is no direct cross tolerance between serotonergic psychedelics and ketamine. They function on different receptors (NMDA for ketamine and HT2a for psychedelics).

However, it is possible that one has a naturally high tolerance to ketamine, so it is therefore possible that one has a tolerance to both without having done either.

Just start off with like 30-50 insufflated (or better yet IM). And work up from there. Small doses of ketamine are really enjoyable.

peace!
 
ketamine and anorgasmia

I have taken dxm many times in the past, which left me unable to achieve orgasm for days after use. Now I am curious about ketamine as It is on the horizon for me.

for those who have used dxm and experienced the inability to orgasm, has ketamine affected you the same way? I am just looking for feedback before I might find out there is no climaxing sex for a week :!
 
ur avatar is from the south park eposode were they take dxm
ive orgasmed while shrooming and on K, so ull b fine
 
I find that Ketamine doesn't affect the ability to climax the way SSRIs or Opiates do.

The prolem with Ketamine and sex has two points:

1. Ketamine is an anaesthetic. That means that you cannot feel the physical stimulation needed in order for your orgasmic-mechanisms to flow. If you rub procaine or some other local anaesthetic on your dick, you will find a similar thing going on.

2. Ketamine tends to make sex unatractive for a lot of people... again, probably because sex is a bodily thing, and Ketamine's primary side-effect is making you lose the body/mind duality and just not "feel" your body in a feedback loop anymore.

Anorgasmia... interesting word. hehe.
 
Two questions about combinations:
Does anyone have experience combining Nimodipine with Ketamine?
I've read a few journal articles that indicate that Nimodipine helps with memory recall after Ketamine use.
http://www.nature.com/npp/journal/v25/n6/full/1395789a.html

"One very interesting focus of another study on KPT in alcoholism was the interactions of ketamine and nimodipine (ref 37). Nimodipine is a calcium channel blocker that is used to treat migraine headaches and complications arising from stroke. The underlying mechanism of ketamine is the blockade of another class of calcium channels. These calcium channels are known to be involved in the processes of thought, memory, emotions, seizures, and the development of alcohol withdrawal syndrome and alcohol dependence. Nimodipine has been previously shown to reverse memory disturbances induced by ketamine, and in this study nimodipine significantly improved the patient's memory of the content of the ketamine psychotherapy session."
http://www.erowid.org/archive/rhodium/chemistry/pcp/effects.html

Also, does anyone have any experience combining Magnesium and Ketamine?
I've read in a few journals that the combo increases the analgesic effects of ketamine, but I haven't heard any human reports of increased effects.
http://www.anesthesia-analgesia.org/cgi/content/abstract/92/5/1173
 
sarsXdave said:
Okay, I've only read through this thread, so sorry if this was brought up in a previous Ketamine Big and Dandy.

I have a friend who went to another college and has had quite a time with ketamine and mentioned that he'll "have to buy me a line." I had been wondering if it'd be out of line for me to ask that I could use it on my own, probably offering to pay for the stuff myself. Any other drug I've done, I'd definitely do it with the person that offered, but it seems like K is an overwhelmingly internal experience for most people. I actually had my first drug experience with this dude, DXM, another (quite different) dissociative, but still found it most rewarding for me when I very occasionally take it and lie down in a dark room with closed eyes and headphones. Said friend has since mentioned that he mostly listens to soul music with K himself.

I realize the thing to do in most situations like this is to be forthright with the person, and not ask them to just give you stuff how you'd like it (again, I'd offer to pay). I guess what I'm mainly trying to ask is whether many of you have found success in doing K with others. I mean, I know some even regard it as a "club drug," but somehow I have my doubts that such socializing won't feel like work or otherwise detract.

I don't think anyone really addressed this, so I'll ramble a bit.

Just ask him to hook it up for you. I seriously doubt he will mind helping you buy a stash of ketamine for your own use if he does this regularly anyway.

Take it in a way that will make you comfortable. Always remember the imortance of set and setting with psychedelic drugs. I don't know how it got a reputation as a "club drug", probably just he media. Low doses can be kind of like alcohol, producing a kind of mild stupor, lack of coordination, things are a little goofy, you slur and stumble a bit. So I can see small amounts being ok or fun for some in a club.

You cannot take a full dose of ketamine in a club... or at least, not the kind of clubs we have where I live. You'll just lay there unresponsive for about 30-60min, drooling on yourself. That kind of stuff attracts attention. You'll look like you've drank yourself unconsious or something.

K is worthwhile to some as a group activity. Personally, I like taking it around friends, as they make me feel safe, esp camping or at a festival or something... so nobody messes with me while I'm out. But I don't really use it as a group activity. We may take it as a group, but its not a group thing... if that makes any sense at all. You aren't going to get all lit up and start talking to each other and running around and drawing with fingerpaints. You're going to be basically knocked out and off inside your head flying around as a beam of light and that sort of thing.

You can have a rough time/bad trip on K, though it doesn't seem to be as common as with non-dissociative psychedelics. So make sure to be comfortable.

If you don't want to do whatever your friend had in mind, don't. When in a group everyone's needs should be met as far as comfort zones.

Maybe try a bit on your own, and then if you want to take it with your friend do so. Just straight up tell him you need to feel it out before you feel good about being around another person. It can be a bit weird.

I've found interacting with my GF to be incredibly difficult and tiresome while on it. I can't communicate for shit, time goes backwards sometimes in my head and other twisted abnormal things.... I'll just try to say "I can't talk right now, out for a while" and it feels like the struggle of a lifetime. I don't even need to say anything, she knows I can't talk, but I'll still feel the need to sometimes if I'm aware enough to notice she is there. Also, sometimes I will manage to move myself into a really weird position or make really fucked up noises or generally look as if I am in major distress when I'm fine. She'll try to see if I ok, and someone asking me if I'm ok all the time makes me wonder if I really am ok... then we go back to the communication problem.

Do what feels right. I couldn't handle soul music on ketamine, jesus, it would drive me completely nuts. I need stuff thats more ambient. droning texture... or chillout, psydub or something like that. Music that makes me floaty and relaxed on its own.
 
Hey guys do you think that 2mg of Xanax and prehaps 50mg of k would be ok? What about a khole dose
 
Okonomi said:
There also seems to be some evidence in animal studies that Vitamin C speeds the onset and increases the duration of Ketamine anaesthesia to some degree. Whether Vitamin C (or Magnesium for that matter) also potentiate the psychedelic effects of Ketamine has not yet been determined - by the medical profession at least.

Vitamin C study:
http://www.termedia.pl/magazine.php?magazine_id=19&article_id=9692&magazine_subpage=ABSTRACT

Im adding some Vitamine C to my next serum of ketamine crystals for IV.
 
^I was thinking more of orally pre-loading with a few Vitamin C drinks (1g effervescent tabs) and Magnesium pills.
 
euphoricnod said:
Hey guys do you think that 2mg of Xanax and prehaps 50mg of k would be ok? What about a khole dose

Sounds like you'll have a nice time, but mixing benzos with Ketamine is likely to dampen the psychedelic aspects of the experience. After all that is the combination used in surgery to make sure you forget any "emergence reactions". So this seems a waste of K, especially for a k-hole dose. Ketamine already reduces anxiety to a certain extent, although the strangeness of the experience can be disconcerting initially, but if you're starting with 50mg I wouldn't worry too much.

2mg Xanax would make me very sleepy indeed, but if you have a tolerance, then you could be fine with that. I sometimes take a benzo to help sleep after a Ketamine session but rarely combine the two.
 
Is there any idea how soon tolerance goes away entirely (or is very low)? I keep my use to once a week max just to avoid getting into the habit of using it, but I'm interested in testing these new ketamine combos (vitamin c, vitamin b12, Nimodipine, Magnesium). I don't want my tolerance to interfere with any of the results, so if people have suggestions for the minimum time inbetween ketamine usage (at the k-hole level), I would appreciate it.
 
Leemo said:
Is there any idea how soon tolerance goes away entirely (or is very low)? I keep my use to once a week max just to avoid getting into the habit of using it, but I'm interested in testing these new ketamine combos (vitamin c, vitamin b12, Nimodipine, Magnesium). I don't want my tolerance to interfere with any of the results, so if people have suggestions for the minimum time inbetween ketamine usage (at the k-hole level), I would appreciate it.
after a day of doing 3-7 grams it takes about 5-6 days till I can still get off like I did when I started the first day. I never have been totaly back to base line with tolerance, when I started IVing my tolerance noticebly went sky high. I sued to be able to completely hole on 50mg IVed and now (well dont know for sure, been like a month sense I touched the stuff) I need 80-100mg. the high is shorter and its more of a rush.


Id also add that the amount of ketamine and routes of administration are not normal for your avarage user. I do suggest that people TRY IVing it, mybe start around 30mg or so and see how they like it. But BE CAREFUL!!!! bamma some of it from yoru self. we (me and my k-tards) got our selves to this point from having grams and grams of ketamine that we never hid from our selves. its like a nitrous, you jst want to keep foing back if its in front of you. saying no is HARD!!!! so yeah, treat ketamine like heroin when IVing. Its good to experience but its horrible to make a habit out of it.
 
The tolerance issue on ket is quite significant, as I've noticed tonight. I'm not a regular user and it had been over a month since my previous experience with the drug until Friday night.

On Friday I had a few small lines with friends and on Saturday I took a bit more, taking me to the 'one foot in the hole' stage. Yesterday I had a small line before bed because my mind was racing and I couldn't chill out - but this line was probably only 15mg or so, so practically negligable. Still, tonight, I've ended up pretty much wasting around 100mg ket, which I split into five lines. I've railed 3 of them over the past 90 minutes and at most I felt a little drowsy and clumsy (though admittedly far more engrossed than I normally would be in the film I was watching). That's pretty crazy, given that on Saturday roughly the same amount gave me effects far beyond this.

This is after just three days of mild use.
 
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