DarkGhost101
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- Joined
- Oct 14, 2014
- Messages
- 5
Tolerance sucks, doesn't it? According to studies, there might be an awesome method to reduce or even eliminate it.
Research has shown that drugs have the opposite effects when used in low doses. This is a theory in toxicology and is called "Hormesis". Hormesis means that low doses of toxins (or drugs) have the opposite effects of normal-high doses.
For example, take Haloperidol. Haloperidol is an anti-psychotic, and it acts as a dopamine receptor antagonist.
It has been demonstrated that Haloperidol works as an indirect dopamine AGONIST in very low doses.
This means - in normal-high doses, Haloperidol reduces dopamine neurotransmission. In low doses, Haloperidol increases dopamine neurotransmission.
Also, with MDMA - a study has shown that small doses of MDMA (<1mg/kg) UPREGULATE serotonin receptors. Normal-high doses of MDMA normally downregulate serotonin receptors, but doses of <1mg/kg UPREGULATE serotonin receptors.
This has been also demonstrated with THC, that downregulates CB1 receptors in normal-high doses, but upregulates CB1 receptors in ultra low doses.
This has also been shown with Amphetamine. Amphetamine normally increases dopamine concentrations by increasing dopamine release. It has been shown that very low doses of Amphetamine REDUCE dopamine release (Amphetamine acts as a Release Inhibitor in low doses) - that means that very low doses of Amphetamine upregulate dopamine receptors (also norepinephrine and serotonin),
This has also been demonstrated with Morphine. Morphine, in normal-high doses, reduces physical pain by activating mu-opioid receptors. But it has been shown that in very low doses, Morphine increases pain sensitivity (very low doses of Morphine reduce endorphin neurotransmission, leading to an eventual upregulation of mu-opioid receptors).
TL;DR: Low doses of drugs have the opposite effects from high doses. That means that low doses of a drug can reverse the tolerance caused by continuous use of high doses of the drug.
I had a personal success with tolerance reduction to Methylphenidate (I once took 1/6th of my usual Methylphenidate dose and it made me much more sensitive to its effects).
What is your opinion about this?
SOURCES:
http://www.ncbi.nlm.nih.gov/pubmed/22244923
http://www.ncbi.nlm.nih.gov/pubmed/25024327
http://www.ncbi.nlm.nih.gov/pubmed/17893922
http://link.springer.com/article/10.1007/BF00406877#page-1
http://www.sciencedirect.com/science/article/pii/S0091305710003497
http://naturalsolutionsradio.com/bl.../ecstasy-manifesto-can-mdma-use-be-made-safer
Research has shown that drugs have the opposite effects when used in low doses. This is a theory in toxicology and is called "Hormesis". Hormesis means that low doses of toxins (or drugs) have the opposite effects of normal-high doses.
For example, take Haloperidol. Haloperidol is an anti-psychotic, and it acts as a dopamine receptor antagonist.
It has been demonstrated that Haloperidol works as an indirect dopamine AGONIST in very low doses.
This means - in normal-high doses, Haloperidol reduces dopamine neurotransmission. In low doses, Haloperidol increases dopamine neurotransmission.
Also, with MDMA - a study has shown that small doses of MDMA (<1mg/kg) UPREGULATE serotonin receptors. Normal-high doses of MDMA normally downregulate serotonin receptors, but doses of <1mg/kg UPREGULATE serotonin receptors.
This has been also demonstrated with THC, that downregulates CB1 receptors in normal-high doses, but upregulates CB1 receptors in ultra low doses.
This has also been shown with Amphetamine. Amphetamine normally increases dopamine concentrations by increasing dopamine release. It has been shown that very low doses of Amphetamine REDUCE dopamine release (Amphetamine acts as a Release Inhibitor in low doses) - that means that very low doses of Amphetamine upregulate dopamine receptors (also norepinephrine and serotonin),
This has also been demonstrated with Morphine. Morphine, in normal-high doses, reduces physical pain by activating mu-opioid receptors. But it has been shown that in very low doses, Morphine increases pain sensitivity (very low doses of Morphine reduce endorphin neurotransmission, leading to an eventual upregulation of mu-opioid receptors).
TL;DR: Low doses of drugs have the opposite effects from high doses. That means that low doses of a drug can reverse the tolerance caused by continuous use of high doses of the drug.
I had a personal success with tolerance reduction to Methylphenidate (I once took 1/6th of my usual Methylphenidate dose and it made me much more sensitive to its effects).
What is your opinion about this?
SOURCES:
http://www.ncbi.nlm.nih.gov/pubmed/22244923
http://www.ncbi.nlm.nih.gov/pubmed/25024327
http://www.ncbi.nlm.nih.gov/pubmed/17893922
http://link.springer.com/article/10.1007/BF00406877#page-1
http://www.sciencedirect.com/science/article/pii/S0091305710003497
http://naturalsolutionsradio.com/bl.../ecstasy-manifesto-can-mdma-use-be-made-safer
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