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The amalgamate molecule thread. Understanding dynamics of what would(n't) work & why?

dread said:
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That all depends if the base molecule can accept multiple protons. Morphine can only accept one proton, it has only 1 proton accepting amine, thus 1 morphine molecule can bind itself to 1 monoprotic acid. Sulphuric acid is a diprotic acid, so one molecule of sulphuric acid can actually bind two molecules of morphine.

Of course you could have a mixture of the hydrochloride and sulphate salts.
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Can this change due to "nanoparticles" and such? Is that too novel a line of research for me to expect and answer or is it easily a shot down idea? ...here maybe I'm getting too far ahead / far fetched, as if asking whether molecules can bend at their branches into waves/strings that curl up smaller into pocket dimensional branes and unfold outward upon activation via metabolism etc. ;-)

OK, back on the thread topic for an additional question; could chaining a molecule together (here lets use morphine for an mode of action and example; or simply a placeholder word), so that there were morphine's that were tethered in a way so that a second could not have activation until the first broke off in a process of metabolism; has this ever been thought of for any chemical as a means to regulate its onset/duration etc of activity? Maybe a mix of morphinex1, morphinex2, morphinex4.... in a solution etc. Maybe what I mean is whether examples of pro-drugs via bonded clone molecules of the drug that potentiate when breaking down by being replications of itself have ever been brought forth or had a theoretical use or are just too much work for what could be done by alternate salts, routes, amounts, estherization?
 
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Ah, simple, simple. ;) ;-p

Another idea would be a molecule that breaks down by being metabolized by several different metabolic pathways that it may randomly reach different pathways regardless of route (or is this always highly unlikely?) If possible it would be so that each of the initially same molecule comes out with different but similar metabolites that would have slightly altered affinity for the same targets. My thought comes as I was reading that analogue molecules with say, a high NE & DAT affinity and later dosed with a separate analogue that is one of higher SERT activity than NE/DAT would potentiate one another as being better than either exposed to a naive to one or the other subject, all just with different levels of affinities; if a single molecule could be a jumble of affinities, breaking down into say three very similar analogues that worked on similar receptors or such but with three variant affinities (not any of the three excluding any others targets, just each having greater at one among their targets but always some affinity for each target out of each metabolite).

dread said:
hydromorphonephenyltrop.png
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Also dread, going back to this. Could you give a little background on what that stimulant branch is thought to do/act as, in and of itself? Short acting like the hydromorphone it is a part of? Any thought of highest affinity, SERT, NE or DAT? etc.
 
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