• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

THC Prevents MDMA - Induced - Neurotoxicity?

Ok.

I just thought there would be reservations and/or clarifications because the last study I posted looked very promising yet some minds more knowledgeable than I in the subject matter revealed it as tenuous at best.

I though the mechanism for neurotoxicity is still unknown though, and the study points to mostly a prevention of hyperthermia as justification.

P-values seemed spot-on.
 
I also read that CBD is neuroprotective so i believe that it would play a role in preventing neurotoxicity from mdma.

The first drugs i ever tried was all uppers. Mdma/ecstasy pills and crystal , i used to go raving but not have weed for when i come back, having never tried it.

I must say its all a lot smoother since haha
 
The linked study involved massive doses of MDMA and THC, so generalizability to human use is difficult. It also focused on DA terminal loss as its dependent measure of damage. When looking at MDMA, people are usually more interested in insult to the serotonergic system.


Ho-Chi-Min said:
P-values seemed spot-on.
Click to expand...

This is true with pretty much any published finding...it suggests that shown statistical contrasts very likely generalizable to the population, but they don't say anything about magnitude of effect or behavioral relevance.
 
I'm very much aware of the indicative nature of p-values (essentially the probability that such results were merely coincidental). And I've read some studies with horrible values. Care to elaborate?
 
An implicit corollary that I should have mentioned is that it's a bit odd to have a meaningful interpretation of how p-values vary continuously. How should we differently approach results unlikely to have stemmed from chance versus results extremely unlikely to have stemmed from chance? It seems only reasonable that all results past a certain p-value cut-off are deemed unlikely type I errors and thus all provisionally treated as "true".

ebola
 
Ho-Chi-Minh said:
I found this: http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009143

Thoughts?

Other sources?
Click to expand...

This study looked at the same interaction in human "cannabis tolerant" subjects:

Cannabis coadministration potentiates the effects of "ecstasy" on heart rate and temperature in humans.
Abstract
This study assessed the acute physiologic effects over time of (co)administration of Delta9-tetrahydrocannabinol (Delta9-THC) (the main psychoactive compound of cannabis) and 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") in 16 healthy volunteers. Pharmacokinetics and cardiovascular, temperature, and catecholamine responses were assessed over time. Both single-drug conditions robustly increased heart rate, and coadministration showed additive effects. MDMA increased epinephrine and norepinephrine concentrations, whereas THC did not affect the catecholamine response. Coadministration of MDMA and THC attenuated the increase of norepinephrine concentrations relative to administration of MDMA alone. These results show that THC mediates heart rate increase independent of sympathetic (catecholaminergic) activity, probably through direct cannabinoid receptor type 1 (CB(1)) agonism in cardiac tissue. Furthermore, THC coadministration did not prevent MDMA-induced temperature increase, but it delayed the onset and prolonged the duration of temperature elevation. These effects may be of particular relevance for the cardiovascular safety of ecstasy users who participate in energetic dancing in nightclubs with high ambient temperature.
Click to expand...

THC had no hypothermic response on its own in these subjects, and didn't affect the MDMA induced hyperthermia either. If these individuals were "cannabis naive" instead of "cannabis tolerant" THC might have been more effective. But in reality, how many people are going to attempt this combination without any sort of tolerance?

Here's another study showing the protective effects of THC in a non-human primate model:

Δ9-Tetrahydrocannabinol attenuates MDMA-induced hyperthermia in rhesus monkeys.

These animals have no THC tolerance, and again the combination is effective.
 
I confirm this but I'm still not sure if it's THC or CBD preventing neurotoxicity. Most articles suggest that it's THC not CBD but the thing is that CBD IS THE NEUROPROTECTIVE compound.
I was under Rick Simpson oil cure and MDMA didn't do much else than a pretty low hyperthermia and no ther effects.
 
Though I have not heard about cannabis being neuroprotective under any circumstances (especially combatting the alleged MDMA nuerotoxicty), I have heard a mild dose of fluroxetine - Prozac - can be helpful in that respect. Cannabis would however be useful to combat nausea.
 
Bumping old thread.

Due to recent experiences I'm wondering if anyone thinks it might be possible for cannabis to not only protect against neurotoxicity but to reverse it as well.

I recently (2 months ago) had an experience and I am almost positive I have neurotoxicity from a combination of mdma, alcohol, and sleep deprivation, as well as dancing which I'm sure produced hyperthermia.

I know this is a long shot but I'm wondering if high dose THC and other cannabinoids may help me regain some function in my life. I've been looking into Rick Simpson Oil but I have heard nothing of it working for neurotoxicity after the fact.

That being said, I have read that it has helped with other degenerative brain diseases such as multiple sclerosis and Alzheimer's, which gives me some hope that it may cure or partially treat the neurotoxicity that I have brought upon myself.
 
I hope CBD prevents neurotoxicity, because I don't want to combine THC with my first MDMA use
 
So the thing about this study...

Allometrically scaling the dose, it calls for about 30 mg THC by injection, which is 60 mg by inhalation or 0.3 grams of 20% THC bud, which is a pretty good THC percentage. And that is assuming you have no prior tolerance.

In other words, THC is neuroprotective, but you have to be pretty fucked up, at least to mimic the effects seen here.
 
Last edited:
You must log in or register to reply here.
Top