THC is a Allosteric Modulator of Opioid Mu and Delta

[basement_shaman]

I think even pure CB1 agonists without opioid modulation cause anxiety.

 

[Coolwhip]

What CB1 agonists don't effect the opioid system?

 

[airsh0w]

What CB1 agonists don't effect the opioid system?

I'm thinking none

"Anatomical studies confirmed the co-existence of MOR and CB1r-ir in common somatodendritic compartments of catecholaminergic neurons in the LC, and also revealed CB1r-positive axon terminals forming synaptic contact with MOR-containing dendrites. "

http://lib.bioinfo.pl/pmid:19931229

I think even pure CB1 agonists without opioid modulation cause anxiety.

An unrelated chemically CB 1 agonist causes anxiety but they all somewhat seem related to opioid function.

http://lib.bioinfo.pl/pmid:17275893