So I was curious about THC derivatives on the hydroxyl group and I came across the acetate version. Loomed interesting and seemed easy enough to do. There is a lot of bad info out there in regards to what THC acetate does so I want to share my experiment.
Prep: to 7 mg of dried, crude oil (previously heated to convert THCA), 50ul of pyridine and 200ul of acetic anhyddride was added. The mix was heated to 125 for 30 min then cooled. The reagents were evaporated off and the oil was dried. It was then dissolved in ethyl acetate and ran through a column of activated carbo for further cleanup. Upon analysi, the conversion of THC to the acetate derivative was completed to roughly 95%. When weighed, the yield of he crude acetate oil was close to 4mg.
Smoked: the oil was evaporated under heat and smoked. This oil was from a sativa plant that I have smoked plenty of times prior so I have a good baseline comparison on the same dose and the effects in comparison to non acetylated oil. The onset was much more gentle and took roughly 45 minutes to peak. The high was not hallucinagenic but it was more glassy and spacey. There was a major difference in the high vs stoned effect. Being a sativa plant, the crude oil brings on a frontal head sort of high tha has almost an intoxicating effect. The acetylated oil was more like an indica stoning effect where it was more in the back of my head and gentle, not intoxicating. What I experienced was more in line with the technical writing floating around that the effects are subtle and pleasant. Overall, it seemed to be equally as potent , so it isn't really worth the chemistry effort to acetylate IMO when smoked.
Oral: he same experiment was done on 6 mg of oil (previously heated to decarboxylate the THCA) but the final yield was not measured. The dried oil was dissolved in hot olive oil and eaten with bread. Here is where it gets interesting. In comparison to eating native extract, the onset was much quicker. Within 45 minutes I felt strong effects and peaked around an hour. In comparison, the crude oil took close to two hours to peak. The effects were interestingly more like smoking rather than oral doses which was surprising to experience. Now the very interesting part. The oral potency seems to have increased by at least two fold maybe three. Usually with crude oil, my oral dosage is 10-12mg. I estimate getting a yield of at least 4 mg after the carbon clean up but I also spilled some of the doped olive oil so it wasn't a full dose yet the effects were close to that of my 12mg oral dose of native oil. More experiments are to follow with oral doses but it seems promising.
Prep: to 7 mg of dried, crude oil (previously heated to convert THCA), 50ul of pyridine and 200ul of acetic anhyddride was added. The mix was heated to 125 for 30 min then cooled. The reagents were evaporated off and the oil was dried. It was then dissolved in ethyl acetate and ran through a column of activated carbo for further cleanup. Upon analysi, the conversion of THC to the acetate derivative was completed to roughly 95%. When weighed, the yield of he crude acetate oil was close to 4mg.
Smoked: the oil was evaporated under heat and smoked. This oil was from a sativa plant that I have smoked plenty of times prior so I have a good baseline comparison on the same dose and the effects in comparison to non acetylated oil. The onset was much more gentle and took roughly 45 minutes to peak. The high was not hallucinagenic but it was more glassy and spacey. There was a major difference in the high vs stoned effect. Being a sativa plant, the crude oil brings on a frontal head sort of high tha has almost an intoxicating effect. The acetylated oil was more like an indica stoning effect where it was more in the back of my head and gentle, not intoxicating. What I experienced was more in line with the technical writing floating around that the effects are subtle and pleasant. Overall, it seemed to be equally as potent , so it isn't really worth the chemistry effort to acetylate IMO when smoked.
Oral: he same experiment was done on 6 mg of oil (previously heated to decarboxylate the THCA) but the final yield was not measured. The dried oil was dissolved in hot olive oil and eaten with bread. Here is where it gets interesting. In comparison to eating native extract, the onset was much quicker. Within 45 minutes I felt strong effects and peaked around an hour. In comparison, the crude oil took close to two hours to peak. The effects were interestingly more like smoking rather than oral doses which was surprising to experience. Now the very interesting part. The oral potency seems to have increased by at least two fold maybe three. Usually with crude oil, my oral dosage is 10-12mg. I estimate getting a yield of at least 4 mg after the carbon clean up but I also spilled some of the doped olive oil so it wasn't a full dose yet the effects were close to that of my 12mg oral dose of native oil. More experiments are to follow with oral doses but it seems promising.
