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Thalidomide now mostly Mycobacteria and spitting

fasteddie

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Anybody ever take any? Yes, I know what it does to fetuses in utero (seen it first hand, in fact) but I heard a few years ago that it can be helpful to AIDS sufferers, for some reason.
 
fasteddie said:
Anybody ever take any? Yes, I know what it does to fetuses in utero (seen it first hand, in fact) but I heard a few years ago that it can be helpful to AIDS sufferers, for some reason.
and leprosy

calling all HIV positive lepers...
 
or treatment resistant Crohn's or colitis...I know people who fit the category, but don't know of anyone who's had thalidomide.
 
fasteddie said:
pthalimide = thalidomide, I think. Ain't rocket science.

phthalimido glutaramide

so phthalimide with a cyclic glutamic acid lactam moety off from the nitrogen.

aint rocket science maybe, but still not clever

one of gruenethals finer products.
 
I stand corrected.

I knew a guy in college who'd been affected by that shit. Pretty extreme.

But, if one weren't even female, and one was looking for something sedating to brew up for personal use...

I'm curious what it's like.
 
fastandbulbous said:
Isn't the PC mob requesting (in their best,'resistance is futile' tone) that we call it Hanson's disease these days?

And why have they decided that a good biblical name isn't good enough and named a nasty disease after a pre-pubescent pop group? =D

:) mmmbop disease

I like the sound of ague as a disease name, just the name sounds uncomfortable and unpleasant.

leprosy(hansons disease) is wierd, I may be wrong but I believe the only animal model for it is the armadillo.
 
vecktor I may be wrong but I believe the only animal model for it is the armadillo.[/QUOTE said:
I heard that too.

There's a natural pallative for it. Chaulmoogra (sp?) oil. It contains fatty acids with cyclopentene rings in the middle of the chain, puts a damper on the organism.
 
It's one of those weird fucked up bacteria in the same line as tuberculosis isn't it? Apparently it's not the easiest of diseases to get, you need some serious self neglect to get it bad

PS Yes ague just instantly conjours up pictures of discomfort and generally not having a very nice time at all. More diseases should have names that convey the suffering involved :D
 
fastandbulbous said:
PS Yes ague just instantly conjours up pictures of discomfort and generally not having a very nice time at all. More diseases should have names that convey the suffering involved :D

Hansons disease fits perfectly then. After two minutes of listening to that shite I'm ready to end it all.
 
fastandbulbous said:
It's one of those weird fucked up bacteria in the same line as tuberculosis isn't it? Apparently it's not the easiest of diseases to get, you need some serious self neglect to get it bad

PS Yes ague just instantly conjours up pictures of discomfort and generally not having a very nice time at all. More diseases should have names that convey the suffering involved :D

They're both Mycobacteria, if memory serves.
 
fastandbulbous said:
That's the bloody name I couldn't remember - don't have a bacterial cell wall so are difficult little buggers to treat...

I'm sure no microbiologist...but TB is extremely wily about developing resistance to antibiotics.

It's also evolved quite a bit, over the centuries...become less virulent. It was once called the "White Plague"...it killed people quickly. Now, it hangs around populations, makes people chronically ill for decades.

It's got a great new ecological niche to occupy, too. Crackheads.
 
fasteddie said:
I'm sure no microbiologist...but TB is extremely wily about developing resistance to antibiotics.

It's also evolved quite a bit, over the centuries...become less virulent. It was once called the "White Plague"...it killed people quickly. Now, it hangs around populations, makes people chronically ill for decades.

It's got a great new ecological niche to occupy, too. Crackheads.

TB is also clever because it is relatively slow growing so difficult to hit using bacteriostatics, hence long treatment times, then there is plenty of opportunity for missed doses which leads to resistance. it is also intersting how the standard vaccine based on Bacille Calmette Guérin has become less effective over time, the suspicion being that there is genetic drift in th BCG strain, it pretty much doesn't work at all now, despite what the medical profession says, and leads to major problems by interfereing with screening using tuberculin in an outbreak. Most people in the past aquired proper immmunity to TB, these are the positive reactors to the tuberculin test, nowadays of course there is little opportunity to acquire immunity to TB. and throw into the mix the reservoir of infection consisting of those with compromised immune systems, those with HIV and multidrug resistant TB we have a big big problem looming.
plus the amount of spitting that occurs in public places, I personally think that it should be a capital offense to spit in a public place, (even on a football field)

There is also talk right now that BCG offers protection against melanoma, which quite frankly strikes me as utter bullshit. see this weeks new scientist in the lettters page.
 
vecktor said:
plus the amount of spitting that occurs in public places, I personally think that it should be a capital offense to spit in a public place, (even on a football field)

I'm not a big spitter...but, when I do, it's in something that I'd...well, consider fit to shit in: a sewer; something thats going to the drain where it's going to be treated; not some sidewalk where it's going to dry out, get atomized for others to breathe.
 
my significant others mom got cervical cancer from her mom using it when she was pregnant and since the germ line is continuous, I reckon my lady friend has used it...

She reports it causes fear of cancer and minimal peripheral effects. Like sitting in front of a pile of ethidium bromide.
 
kidamnesiac said:
my significant others mom got cervical cancer from her mom using it when she was pregnant and since the germ line is continuous, I reckon my lady friend has used it...

Sure you don't mean DES? Diethylsilbestrol, if memory serves.
 
I thought that thalidomide only caused problems to developing babies if it was taken in the first trimester?
it is not a causative agent for non-somatic damage in humans as far as I am aware. there have been a couple of scare media reports, but these do not appear to withstand scrutiny.
As for DES causing non-somatic damage, the evidence is again patchy.
Very few chemicals are capable of producing non-somatic and therefore inheritable damage there is certain evidence that Dioxin can and limited evidence that radiation can and does. which is good given that most of humankind is descended from the survivors of a genetic pinch. more concerning would be a substance that causes specifically mitochondrial genetic damage.
 
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