Testimony of Various ADs-Moclobemide

[Davevanza]

Here's my experience :

• Prozac (Fluoxetine)
Gives me akathisia,I can't focus clearly,it only inhibits reuptake of Serotonin. I read in some research papers that it has an indirect antagonist of Dopamine (it's sort of antipsychotic like effect, causing restlesness, not stimulant like effect as some sources stated wrongly. ).

• Paxil and Luvox
A bit sedating, luvox is more sedating, has anticholinergic effect, as for memory booster,anticholinergic is not what we want.

• All tricyclics
Sedating. Not much useful as to clear up the thinking process. It's referred as "Dirty mood brighteners". (found in www.biopsychiatry.com)

• Mannerix/Aurorix (Moclobemide) - ( MIMS online)
I find it helpful. But,I make sure to crush the hard tabs,swallow it on empty stomach with water. I take it 300mg early morning,300mg around 3pm. It works great.
It increases Serotonin,Noradrenaline,Dopamine,PEA, in the brain, by inhibiting MAO-A (MAO-B,too,at higher dose). I find it non sedating, no mental cloudiness unlike SSRI/SNRI or TCA etc. It's also non stimulating unlike Ritalin etc.
I just feel happy,after taking it. It must be bcoz of the increase in Neurotransmitters in my brain. I feel I could focus,think clearly. My mood is is stable, and I don't feel depressed while on it.
It has a short half life- 2 hours. But inhibition of Monoamines is up to 24hours.

But, allow 2-3 weeks bfore I notice the effect. After the body adjust to it,then increase the dose, max 600mg/day.
Many people derive little benefit,I think bcoz of the absorption. So I crush the tabs and swallow with water to ensure high bioavailability.

 

[Divine Moments]

I don't quite get the point of this thread (no offence).. But I agree, I find moclobemide to have the least side effects (and at fairly similar antidepressant effect) of any anti-d I've tried. I had to tell me GP what it was though - he said he'd prescribed it once before, and he isn't young!

 

[Davevanza]

Aurorix ( Moclobemide) is a RIMA ( Reversible Inhibitor of Monoamine-A).
Unlike the Non-selective ones, Parnate ( Tranylcypromine) which is metabolised into amphetamines, very stimulating, and Nardil ( Phenelzyne), a bit sedating, Moclobemide if taken after meal, doesn't interact with Tyramine induced hypertension ( causing intracranial bleeding to some people back in the 60's).

So Aurorix is a safe med.
As I search through MIMS Annual, it has little hepatotoxicity, nor effecting the renal function via its clearance.

Just make sure, never take in with Pethidine, DXM, and Serotonin Agonists ( Sumatriptan, all Triptans, and SSRI's/ SNRI's)

 

[ziggaz]

I got the same restleness feeling whilst on prozac..
Not as bad as Paroxetine though, worst AD i have ever taken. Felt sick all the time and would often skip taking the pill.

 

[Davevanza]

I think it's bcoz Prozac has a long half life. It stays in the body for up to 3 days, not to mention its metabolites too, even longer.

I just come across from www.prozacweekly.com last time that it is available as a weekly tablet.
So just taking 1 tablet ( Prozac 90mg) every Mon morning will be a maintenance dose.

A bit shocking !! As 90mg is used weekly, as some GP prescribe even 20-40mg daily, and that could be as little as 150mg, or over, in a week.

And no wonder, when I took it, I feel a bit restless, as the metabolites are building up in my body, leading to "over dose effect". Taking it every other days would lessen its agitation effect I guess.

Cheers
Dave