pseudoSym
Bluelighter
Hey,
Just wondering if someone could translate the relevant sections for me? I'm trying to work out how long temazepam will affect me.
I intend to use it after a night out on the amphetamines. Not sure if it's pertinent, I'm of a solid build and seem to have a relatively larger tolerance to most drugs, illict or otherwise.
"In a single and multiple dose absorption, distribution, metabolism, and excretion (ADME) study, using 3H labeled drug. Temazepam was well absorbed and found to have minimal (8%) first pass metabolism. There were no active metabolites formed and the only significant metabolite present in blood was the O-conjugate. The unchanged drug was 96% bound to plasma proteins. The blood level decline of the parent drug was biphasic and the short half-life ranging from 0.4-0.6 hours and the terminal half life ranging from 3.5-18.4 hours (mean 8.8 hours), depending on the study population and the method of determination. Metabolites were formed with a half-life of 10 hours and excreted with a half-life of approximately 2 hours. Thus, formation of the major metabolite is the rate limiting step in the biodisposition of temazepam. There is no accumulation of metabolites. A dose-proportional relationship has been established for the area under the plasma concentration/time curve over the 15-30 mg dose range."
Source: http://www.rxlist.com/cgi/generic/temaz_cp.htm
I suppose I should ask is Temazepam even the best to use for my purpose?
Much obliged to anyone who can help me!
Rock on.
Just wondering if someone could translate the relevant sections for me? I'm trying to work out how long temazepam will affect me.
I intend to use it after a night out on the amphetamines. Not sure if it's pertinent, I'm of a solid build and seem to have a relatively larger tolerance to most drugs, illict or otherwise.
"In a single and multiple dose absorption, distribution, metabolism, and excretion (ADME) study, using 3H labeled drug. Temazepam was well absorbed and found to have minimal (8%) first pass metabolism. There were no active metabolites formed and the only significant metabolite present in blood was the O-conjugate. The unchanged drug was 96% bound to plasma proteins. The blood level decline of the parent drug was biphasic and the short half-life ranging from 0.4-0.6 hours and the terminal half life ranging from 3.5-18.4 hours (mean 8.8 hours), depending on the study population and the method of determination. Metabolites were formed with a half-life of 10 hours and excreted with a half-life of approximately 2 hours. Thus, formation of the major metabolite is the rate limiting step in the biodisposition of temazepam. There is no accumulation of metabolites. A dose-proportional relationship has been established for the area under the plasma concentration/time curve over the 15-30 mg dose range."
Source: http://www.rxlist.com/cgi/generic/temaz_cp.htm
I suppose I should ask is Temazepam even the best to use for my purpose?
Much obliged to anyone who can help me!
Rock on.
