I'm making trials with Telmisartan. It's a blood pressure drug, a angiotensin II antagonist (AT1 receptor blocker "ARB"). It appears to be a selective pan PPAR agonist, with activity at all PPAR receptors, but selective to certain parts of the body...an SpPPARM
It affects PPAR alpha in the liver, and lowers liver fat quickly. (Incidentally, excessive liver fat is mainly from drinking, a well problem, but also lately is happening from eating poorly, Nonalcoholic Steatohepatitis, making telmisartan a aid for people who are obese and want to start exercising, this is a little bit of a shortcut.)
It affects PPAR delta in skeletal tissue. This is where the endurance effect of GW 501516 comes from.
It affects PPAR gamma in various tissues. This is probably not a desired effect in this group, but its delta effects appear to be stronger than gamma if i'm reading things correctly.
Telmisartan reaches maximum angiotensin II antagonism around the 80mg oral dose. According to studies and in my own test, larger doses appear to have no further effect for the drug's original purpose as an ARB. I notice no significant difference in the most obvious effect of the drug at 80, 160, or 240mg. The most obvious effect, aside from reducing blood pressure, is that it seems to make me slightly calmer, lowers the chatter in my mind, comparable to the effect of a long term, very low carb diet. This "calm" is definitely an effect GW 501516 does NOT have.
So this leaves the question, how does this drug rate against GW 501516 for increasing ATP-producing mitochondria (for endurance) and fat loss?
To get the PPAR delta effects, you definitely have to start at 80mg. 1-5mg/kg is the dose range that people have been testing. I've only gone up around 2.5mg/kg. It's nowhere near as strong as GW 501516 by weight. But by being more of a selective agonist, it's already an easily available prescription drug instead of a drug which is known to cause cancer aggressively through all tissues in rats.
At 240mg, I notice similar endurance boosts to larger doses of GW 501516 (20mg+).
Nothing else to report yet.
It affects PPAR alpha in the liver, and lowers liver fat quickly. (Incidentally, excessive liver fat is mainly from drinking, a well problem, but also lately is happening from eating poorly, Nonalcoholic Steatohepatitis, making telmisartan a aid for people who are obese and want to start exercising, this is a little bit of a shortcut.)
It affects PPAR delta in skeletal tissue. This is where the endurance effect of GW 501516 comes from.
It affects PPAR gamma in various tissues. This is probably not a desired effect in this group, but its delta effects appear to be stronger than gamma if i'm reading things correctly.
Telmisartan reaches maximum angiotensin II antagonism around the 80mg oral dose. According to studies and in my own test, larger doses appear to have no further effect for the drug's original purpose as an ARB. I notice no significant difference in the most obvious effect of the drug at 80, 160, or 240mg. The most obvious effect, aside from reducing blood pressure, is that it seems to make me slightly calmer, lowers the chatter in my mind, comparable to the effect of a long term, very low carb diet. This "calm" is definitely an effect GW 501516 does NOT have.
So this leaves the question, how does this drug rate against GW 501516 for increasing ATP-producing mitochondria (for endurance) and fat loss?
To get the PPAR delta effects, you definitely have to start at 80mg. 1-5mg/kg is the dose range that people have been testing. I've only gone up around 2.5mg/kg. It's nowhere near as strong as GW 501516 by weight. But by being more of a selective agonist, it's already an easily available prescription drug instead of a drug which is known to cause cancer aggressively through all tissues in rats.
At 240mg, I notice similar endurance boosts to larger doses of GW 501516 (20mg+).
Nothing else to report yet.