Technical Gbl Question Regarding Prolactin

[sirbishop]

Sup everybody. Just wondering if anyone had any input on this. From my understanding:

-After male orgasm prolactin is released resulting in a "refractory period"

-Dopamine is related to sexual excitment. More dopamine = more arousal ect.

Hope the above is correct (at least from my research it seems to be)

GBL/GHB is known to inhibit the release of dopamine and release more prolactin. If this is the case what is the mechanism behind GHB/GBL's prosexual affects?

I always though serotonin affected sex drive negatively. As with SSRIs and such. When under the influence of GBL/GHB aren't serotonin levels high and dopmaine levels at a minimum?

does this have something to do with GABA?

Thanks

 

[felix]

F&B: I saw this thread and i thought of you.

opinions are divided on where to put this one. if you disagree, please let me know.

 

[vecktor]

I have always assumed pretty much that the prosexual effects of gamma hydroxy butyrate and GBL have to do with the dopaminergic effects combined with some of the sedative, inhibition reducing effects.
other agents which increase synaptic dopamine like MDPV are prosexual. similarly some of the GABA allosteric modulators which increase GABA activity and reduce inhibitions are prosexual.
I don't see any need for any other mechanism, prolactin release is very closely related to dopaminergic activity, so it could be a consequence of the
DA activity rather than something separate.

 

[JASS92]

I would say this primarily has to do with lowered inhibition (promotion of GABA) while simultaneously being "aroused" from the dopamine. However, most would attribute this to serotonin too, and it is hard to tell the N.T.'s select effects apart.

 

[sirbishop]

alcohol affects GABA receptor sites right? resulting in lowered inhibition. I can see how this would result in prosexual effects. However, I believe there is something more. My erections are harder and actually last longer and my actual libido (sexual motivation) even after orgasm is stronger. GBL/GHB inhibits Dopmaine so I dont' see how dopamine could be a factor in this. But who knows, i'm not a chemist but kinda wish I got into it fresh outta high school. its one thing taht really sparks my interest.

 

[nelix]

It was my understanding that GHB did not inhibite dopamine release... And dopamine hates prolactin... Hence GHB is awesome.

Pretty bro science explanation in my mind. I would love someone with a few more brain cells to chime in.

 

[Ham-milton]

Does gamma-hydroxybutyrate inhibit or stimulate central DA release?
Author(s)
Feigenbaum JJ, Howard SG
Department of Research and Development,
American Institute of Biotechnology,
Elk Grove Village, IL 60007, USA.
Int J Neurosci 1996 Nov; 88(1-2):53-69

ABSTRACT

Gamma-hydroxybutyrate (GHB), a four-carbon fatty acid and anaesthetic, is widely considered to be a relatively specific inhibitor of central dopamine (DA) release. The inhibitory effect of GHB on the latter is thought to occur as a consequence of its diminution of impulse flow in central dopaminergic neurons. However, a number of studies have recently reported that GHB primarily stimulates rather than inhibits central DA release, with any inhibitory effect produced of a modest and transitory nature. GHB has been and continues to be widely used as an important research tool largely because it is one of only a few drugs available that acts primarily on DA release. Consequently, it is important to determine whether GHB inhibits DA release as previously thought, or stimulates DA release, as more recently suggested. Following a critical review of the literature, the present report suggests that GHB does inhibit rather than stimulate presynaptic DA release in consonance with its behavioral and pharmacological activity. Recent in vivo studies indicating that GHB stimulates DA release were done under anaesthesia or in the presence of a high concentration of calcium. Both conditions have been found to spuriously enhance striatal DA release in vivo, which may account for the failure of some studies to observe an inhibitory effect of GHB on DA release in vivo.

So under some conditions it can, but under normal conditions it does inhibit DA release.

I don't understand why GHB has such a massive addictive potential if it prevents DA release. It explains the horrible withdrawal, though.

 

[sirbishop]

yea the withdrawls are actually surges of stored dopamine flooding your "brain." Too much dopamine results in increased blood pressure, rapid heart rate, anxiety, ect...also increased libido....thats y i don't understand how GHB has pro sexual side effects...Serotonin has negative impacts on sex drive...any how, I wish i really knew the "truth" about GHB, cause from reading different "things" on the internet the information is so mixed. Some claim it to be extremely beneficial to one's health (With the increase of growth hormone release) and some claim it to be extremely hazardous. thanks for posting fellas