Will you dm me for more info?Interesting you say it's like gold dust to get, I find it's the safest and easiest to obtain. They come in blister packs so it's guaranteed it is what it's supposed to be. I wish i could tell you the source, but we are not allowed to post that info. Super cheap tho, 200 pills usually comes to $65.
I didn't like them at first, would only use it occasionally for breakthrough pain rather than more oxy or hydrocodone. But now it's the only opiate i take, I ingest orally 100mg per dosing, not the slow release formula. Most days it's 2 -3 times. If I find myself taking 4 per day, i usually start the next day with 150mg dose and then only 50mg one more time during the day. I've been using them daily for the most part for 6+ months now. Definitely have become physically dependent but the side effects are very minimal compared to all other opiates, and i've tried them all.
They also go very well with my prescribed Valium, that takes all the speedy effects away and definitely gets me nodding if I accidentally re dose the valium.
Throw Soma into the mix and you got one hell of a cocktail, but this is not encouraged or advised.
Feel free to message me if you want to chat, i like tapentadol buddies
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OD Moderators: Keif’ Richards | negrogesic
Opioids Tapentadol Megathread
- Thread starter ghostfreak
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4DQSAR
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OK - I have noted a few really odd things about tapentadol.
I've read claims that it's affinity for the MOR is just 1/50th that of morphine and a few sources give the affinity µM, not nM which sort of agrees with that statement.
HOWEVER I'm almost certain I've also read that tapentadol is classed as a 'superagonist' i.e. it only weakly binds to the MOR, but it's activity at the MOR is far higher than classical opioids.
This MAY explain why although not that potent (I note the BNF suggests a minimum dose of 50mg although 250mg SR formulations are available), it appears to produce notable analgesic activity but at the cost of a particularly nasty AWS.
In the UK one consultant has even written a paper specifically on the topic of tapentadol detoxification. I'm assuming that for people who get on with or even enjoy the stimulant activity, that AWS might be significantly different in character.
Forensic journals appear to suggest that somewhat like tramadol, fatal overdoses may not present in the same manner as those produced by 'classical' opioid with seizures being a particular issue. I have no idea of the scale of the problem but the UK government was sufficiently concerned to release a warning:
www.gov.uk
I am prepared to bet that tapentadol, like tramadol, will fall out of favour with British clinicians. Maybe not an outright ban, but I can imagine clinicians deciding that in patients for whom tapentadol is will tolerated, they will continue to prescribe... but I suggest that it will become a second-line treatment in new patients. I was never offered the stuff but then again, I am subject to seizures so presume my doctor discounted tapentadol out of hand.
I've read claims that it's affinity for the MOR is just 1/50th that of morphine and a few sources give the affinity µM, not nM which sort of agrees with that statement.
HOWEVER I'm almost certain I've also read that tapentadol is classed as a 'superagonist' i.e. it only weakly binds to the MOR, but it's activity at the MOR is far higher than classical opioids.
This MAY explain why although not that potent (I note the BNF suggests a minimum dose of 50mg although 250mg SR formulations are available), it appears to produce notable analgesic activity but at the cost of a particularly nasty AWS.
In the UK one consultant has even written a paper specifically on the topic of tapentadol detoxification. I'm assuming that for people who get on with or even enjoy the stimulant activity, that AWS might be significantly different in character.
Forensic journals appear to suggest that somewhat like tramadol, fatal overdoses may not present in the same manner as those produced by 'classical' opioid with seizures being a particular issue. I have no idea of the scale of the problem but the UK government was sufficiently concerned to release a warning:
Tapentadol (Palexia): risk of seizures and reports of serotonin syndrome when co-administered with other medicines
Tapentadol may increase seizure risk in patients taking other medicines that lower seizure threshold, for example, antidepressants and antipsychotics. Serotonin syndrome has also been reported when tapentadol is used in combination with serotoninergic antidepressants.
I am prepared to bet that tapentadol, like tramadol, will fall out of favour with British clinicians. Maybe not an outright ban, but I can imagine clinicians deciding that in patients for whom tapentadol is will tolerated, they will continue to prescribe... but I suggest that it will become a second-line treatment in new patients. I was never offered the stuff but then again, I am subject to seizures so presume my doctor discounted tapentadol out of hand.
Yeah, on 2-3 weeks straight of no opioid is, at 225 lbs, and missing most of my digestive tract, 500mg was where I started to feel it and I'm not sure why.
For safety's sake, this could easily kill, do not replicate it even if heavier than I was.
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4DQSAR
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Then why do they produce 25,50, 75 and 100mg IR formulations?
If YOU barely feel 150mg either you are in that small group of refractive patients for whom tapentadol simply doesn't work and/or you have developed a huge tolerance to the stuff. Either way - offering ill considered advice can get other killed, so DON'T!
For me, the tremendous anxiety it produced made it intractable as a potential treatment and that was just a single 25mg tablet. I think from that my clinician divined that it simply was not an option.
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