Talampanel

[_VR]

As a former "enthusiastic" drug user and occasional lurker to this forum, I created this account to make this, my first post. I saw a diagram of this molecule (
http://en.wikipedia.org/wiki/Talampanel ) and it had that look about it. Synthesized starting with a reduction from 3,4-MDA *and* it's a benzodiazepene? Am I silly for thinking this looks interesting?

Thanks.

 

[Hyperthesis]

Well, it looks as interesting as an anti-epileptic agent just looks. If you could get your hands on a sample, I'd say that it is worth a try, but for self-preparation is the synth far too complicated (see: "Process chemistry in the pharmaceutical industry", Marcel Dekker 1999, Vol. 1, p.263). Not intending to go further into detail, as synth discussion is still verboten at Bluelight.

The fact that this compound contains a methylenedioxy-bridge is not too impressive. Lots of stuff has such a moiety... The presence of a primary aniline isn't really calming.

 

[Hammilton]

second the concern about the primary aniline! Kind of screams hepatotoxicity.

^ To be fair, though, this drug doesn't just contain a methylenedioxy bridge, it contains the whole MDMA molecule in its substructure.

 

[_VR]

Yes, I was hoping I didn't just get shot down as another "stick a 3,4-md bridge on it and hope" type post.
I really think this molecule looks interesting for all reasons thus far mentioned.
It's AMPA and GABA actions are interesting.
The paper at
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978282/ seems quite interesting. MDMA, benzodiazepene, *neuroprotectant*?!, what's NOT interesting about this drug?

 

[Nagelfar]

*and* it's a benzodiazepene?

Benzodiazepine is technically a structure type and not an effect profile. (e.g. "nonbenzodiazepine class" drugs have the effect without the structure.) For instance check out GYKI-52895; it's a benzo in structure solely, but no such effect, its effect profile is a selective dopamine reuptake inhibitor.

 

[_VR]

^ ^
Certainly a point. And I've been looking at the 2,3-benzodiazepenes and the differences in action from classic "benzos." I guess that's primarily why I found the molecule interesting to look at; playing the SAR game, looking at the various subtituents. Thanks for the reply.

 

[Nagelfar]

^ ^
Certainly a point. And I've been looking at the 2,3-benzodiazepenes and the differences in action from classic "benzos." I guess that's primarily why I found the molecule interesting to look at; playing the SAR game, looking at the various subtituents. Thanks for the reply.

The 2,3-benzos, due to those two examples, might be a good area to look for an ampakine + DRI drug. Which would be a very interesting find for a single molecule.