Taking a 5-HT3 receptor antagonist with a nausea-causing 5HT agonist psychedelics

[sheepie]

To combat nausea.

People sometimes get nauseated with mescaline/shrooms/LSD. This could be partially due to digestive factors (in the case of shrooms and mescaline especially); however in the case of taking pure mescaline people still note strong nausea. This is probably because of the 5HT3 agonist effect. I wonder if taking a 5HT3 antagonist such as Ondansetron could eliminate nausea without reducing the trip. Ideas?

 

[PsychedelicPeptide]

I'm not sure you can say it is only the 5HT3 receptor that causes GI effects. It could be any 5HT subtype in the gut or linked to gut processes by the brain. But that's not to say it isn't worth a try. Someone mentioned eating ginger in another thread to combat nausea recently, I had success with it years and years ago with something but forgot all about it...

http://en.wikipedia.org/wiki/5-HT_receptor

good info: http://www.medscape.com/viewarticle/528890_6

 

[negrogesic]

Its about selectivity. Promethazine should do the trick without a significant alteration. Compounds such as meclozine are more accessibility (promethazine is rx-only in the US), and will likely not interfere. Mirtazapine certainly does, but it even then, does not eliminate the effect of potent psychedelics. If you are taking mescaline via 'san pedro', its hard for any drug to really keep that volume down. LSD can make people have significant GI disturbances, as do mushrooms, but by the time of emesis, the psychoactive effects are profound. Never had any pro-emetic responses from any drugs of this class apart from from 2-CT-7, and that is a rough compound, and the dosing was too high..........

 

[sackynut]

ondansetron help eliminate the nausea for me almost 100%, and does not effect a SINGLE other thing, not the trip, not the anxiety, not the headspace or visuals ONLY the nasuea. it is very very selective and actually is my miracle drug, while on drugs haha. i always have some on hand when doing any sort of stim or 5-ht based drug.

 

[reformer]

ondansetron help eliminate the nausea for me almost 100%, and does not effect a SINGLE other thing, not the trip, not the anxiety, not the headspace or visuals ONLY the nasuea.

Yes... I keep Granisetron on hand for the same purpose.

Simply Amazing.

 

[sheepie]

Cool beans thanks for the info guys

 

[PsychedelicPeptide]

You can also try ginger, preferably fresh if you don't want to take the pharmy route. Dice up the root, heat some water and mix in the roots and let sit for 10 minutes. Then strain the plant material and make sure to push down on the roots in the strainer to get all the water they soaked up out of them. Mix this with lemonade or lemon-line flavored drinks or just have it as tea. You can resoak the root as well, I got 4 glasses of tea from 1/4 lb root last night, enough to last all night. Drink a big glass 1-2 hours before ingesting drugs then sip more if you feel your gut turning south (particularly important if you are redosing). Or you can just chew the root. Ginger has a very powerful digestive enzyme in it.

That and digestive enzyme blend capsules available at nutrition stores. Pop a few before and during the trip.

These will help your stomach more effectively digest any and all things that come into being in your stomach during a trip, hence eliminating any potential for nausea.

 

[sackynut]

^agreed somewhat. but ive used those digestive enzymes before during drug use and they dont help at all. most peoples stomachs work fine as is.

some of the nausea from drugs are indeed caused by it reacting with your stomach lining. but most of the nausea is actually purely in the brain, and being controlled by serotonin at the 5ht3 receptor. hence what ondansetron and other 5ht3 antagonists work so damn well!

 

[reformer]

Go Pharma

Ginger can be a mild but somewhat effective possible remedy against non-serious nausea.

Ginger does not contain digestive enzymes, anymore so than any other plant contains intracellular proteases, lipases and glucosidases.

Ginger's effect definitely stems from it's high concentration of zingerones which apparently dampen the signalling of nausea (although I don't know much about this are of phytochemistry).

Also, taking encapsulated digestive enzymes is not going to provide ANY benefit whatsoever. Unless you ate a huge, rich meal before dosing, in which case you already violated the law of set and setting and your hope of additional digestives is placebo at best.

Enzymes won't cut muster. There is no mechanistic explanation that can be offered to propose a benefit from digestives. It isn't a lack of digestion that causes the problem in the first place.

5HT3A Antagonists *will* stop nausea from 5HT-based entheogens... or you can try zingerones which might possibly sometimes maybe help under certain limited circumstances with some individuals.