daturetard
Bluelighter
- Joined
- Apr 4, 2024
- Messages
- 1,249
Any experience with this one? Not controlled anywhere, widely used as a perennial ornamental vining (sort of) plant. I've got a cutting that I'm trying my absolute hardest not to let wilt on me. It contains ibogamine and other iboga and vinca type alkaloids.
One alkaloid that looks very promising to me is conolidine, which acts on a novel opioid receptor known as ACKR3, which an excerpt of the Wikipedia (great source ik but I'm too faded to go further down the result page to find some better) article reads as follows
"In addition to CXCL12[endogenous peptide], ACKR3 engages with multiple ligands, encompassing CXCL11, macrophage inhibitory factor (MIF), adrenomedullin (ADM), opioid peptides such as nociceptin, dynorphin, and enkephalin, as well as the viral chemokine vCCL2/viral macrophage inflammatory protein-II.
Inhibition of ACKR3 by ligands such as the peptide LIH383 (FGGFMRRK-NH2) and the small molecules conolidine, RTI-5152-12, and VUF15485 increases opioid peptide activity and produces analgesic and antidepressant effects in animal studies."
This makes me hopeful for its use as an anti addiction remedy for those of us who's governments are so fucking ignorant about iboga, and not only that, but could also be very good for pain patients I would imagine, it's said to have antinociceptive potential without addictive properties or constipation, and I would imagine that it's not very 'recreational' though I've only ever smoked a couple leaves in some spliffs, which left an odd taste and lots of resin due to the milky latex. Not enough to really feel it though this one might not be smokable for effects
conolidines namesake is that the researchers who discovered/and or tested it didn't know about this opioid receptors existence, so the binding profile looked similar to conotoxin, Ca2 Channel blockage I believe is the specific reason, they thought the antinociception was due to this pathway.
From what I'm getting it looks like it might be similar to nociceptin, an endorphin. Albeit not in structure..
Ok last thing, promise; I want to throw two leaves into my next batch of corn
poppy tea and see how they interact, I see it going one of two ways; it does some magical fusion dance and i find a great potentiator, or it puts me into precipitated withdrawal like can happen with bupe (and iboga, I think?)
Should I do it? I mean I'll be wasted the whole day either way but one's bad...
One alkaloid that looks very promising to me is conolidine, which acts on a novel opioid receptor known as ACKR3, which an excerpt of the Wikipedia (great source ik but I'm too faded to go further down the result page to find some better) article reads as follows
"In addition to CXCL12[endogenous peptide], ACKR3 engages with multiple ligands, encompassing CXCL11, macrophage inhibitory factor (MIF), adrenomedullin (ADM), opioid peptides such as nociceptin, dynorphin, and enkephalin, as well as the viral chemokine vCCL2/viral macrophage inflammatory protein-II.
Inhibition of ACKR3 by ligands such as the peptide LIH383 (FGGFMRRK-NH2) and the small molecules conolidine, RTI-5152-12, and VUF15485 increases opioid peptide activity and produces analgesic and antidepressant effects in animal studies."
This makes me hopeful for its use as an anti addiction remedy for those of us who's governments are so fucking ignorant about iboga, and not only that, but could also be very good for pain patients I would imagine, it's said to have antinociceptive potential without addictive properties or constipation, and I would imagine that it's not very 'recreational' though I've only ever smoked a couple leaves in some spliffs, which left an odd taste and lots of resin due to the milky latex. Not enough to really feel it though this one might not be smokable for effects
conolidines namesake is that the researchers who discovered/and or tested it didn't know about this opioid receptors existence, so the binding profile looked similar to conotoxin, Ca2 Channel blockage I believe is the specific reason, they thought the antinociception was due to this pathway.
From what I'm getting it looks like it might be similar to nociceptin, an endorphin. Albeit not in structure..
Ok last thing, promise; I want to throw two leaves into my next batch of corn
poppy tea and see how they interact, I see it going one of two ways; it does some magical fusion dance and i find a great potentiator, or it puts me into precipitated withdrawal like can happen with bupe (and iboga, I think?)Should I do it? I mean I'll be wasted the whole day either way but one's bad...
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