T. Bridgesii Catcus + DMT = Cactihuasca?

[Deleted member 193777]

Hi all,

I've been a lurker here for awhile as a member and even longer as a non-member... surprisingly (or not I guess) most questions I have about substances are discussed and answered on the boards before I ever think of them, but in this case I have not found any directly useful info. What I'm wondering is whether, since the Trichocereus bridgesii cactus is known to have both mescaline and at least one MAOI (if anyone wants to clear me up on the veracity of that I'm all ears), one could add some crystalline N,N-DMT to the tea/juice of the cactus and expect to experience a combined oral DMT/mescaline trip. It seems to me that this should work... is there any reason why it would not? Better yet, has anyone tried this?

Peace out, and thanks!

 

[IamMe90]

Last I recall the jury is still out on whether or not t. bridgesii contains any MAOI activity, let alone activity significant enough to inhibit the breakdown of DMT in the stomach.

 

[Deleted member 193777]

Last I recall the jury is still out on whether or not t. bridgesii contains any MAOI activity, let alone activity significant enough to inhibit the breakdown of DMT in the stomach.

Hmm... I didn't know this was disputed... :/ I read somewhere that 90% of the mescaline makes it through the first gastric pass or something due to the existence of an MAOI. Thanks for the quick reply.

 

[IamMe90]

As far as I know mescaline has a high oral bioavailability anyway so I'm not sure why an MAOI would be needed for that.

 

[Deleted member 193777]

As far as I know mescaline has a high oral bioavailability anyway so I'm not sure why an MAOI would be needed for that.

I'll see if I can find where I read that but supposedly 50% of mescaline is destroyed instantly in the stomach without an MAOI.

EDIT: I guess I read it here: https://mycotopia.net/forums/storming-gates/83243-bridgesii-effects.html#post1057068

Bridgesii has its own flavonoids that act as maois, this allows a WHOLE SHIT LOAD of mescaline to make it though the first gastric bypass, This means that instead of getting around 50% of the mescaline you are getting 90% of it. This particular cactus's alkaliod profile has a sedative effect to it which kinda lays you down a bit as its coming up, this to me is very pleasing as the sedative effect does wear off after a couple hours, seems that once the visuals kick in good the sedative effect is almost nil. You will get a very strong loving body high from this cactus much the same as you would from the other 3 only to a greater degree, the visuals will be ALOT more intense and it can scare the shit out of you if you fuck up and take to much but, thats the fun part right.

This guy seems to have found that MAOIs have been identified via GC/MS here:
https://mycotopia.net/forums/botani...onstrose-dose-how-many-inches.html#post856210

whoooops!,
spoke to soon,
I was wright and wrong.

apears that kaempferol and quercetin are flavonols AND maoi's.

. These MAOIs were identified by high-resolution mass spectrometry as kaempferol and isorhamnetin.

Quercetin was the only compound with a selective inhibitory activity against MAO-A

well just little quotes from long articles that seem promising....
These actually came from links I found here posted by Irishlion.

Another reason why I spend alot of time here at Mycotopia

Ah, this seems to be the mother lode right here:
https://mycotopia.net/forums/botanicals/79718-filter-bridgesii-tea-point.htxml#post1020391

here is the link that shows the main active chemicals in bridgesii

http://mycotopia.net/forums/mescalin...eus-cacti.html

Which are

Trichocereus bridgesii

Mescaline 50/100g fresh >50%

3-Methoxytyramine <1%

3,4-Dimethoxyphenylethylamine <1%

Tyramine <1%

Bridgesigenin A

Bridgesigenin B

Kaempferol Flavonoid acting as a Mao-i

Quercetin Flavonoid acting as a Mao-i


Now as you see above Kaempferol and Quercetin are labeled as flavonoids because in fact they are.

Kaempferol

http://en.wikipedia.org/wiki/Kaempferol

Quercetin

http://en.wikipedia.org/wiki/Quercetin

Here the studies that have proven that they also act like Mao-i

Kaempferol

http://cat.inist.fr/?aModele=afficheN&cpsidt=1335695

Quercetin

http://pubs.acs.org/doi/abs/10.1021/np060015w

 

[IamMe90]

What are the amounts of kaempferol and Quercetin present in bridgesii, how selective are they as MAOIs and is there presence significant enough to inhibit MAO to the degree needed for oral DMT? I'm just not sure about that. By all means give it a try though!

 

[mecaib]

Slightly OT, but I feel it should be mentioned that combining foreign MAOIs with various cacti might result in a hypertensive crisis. Taking Bridgesii alone with oral DMT is probably safe, but adding new MAOIs to the mix could be potentially fatal. Here's something from Erowid that might be useful: Are MAOIs dangerous in combination with some Trichocereus cacti?

Thought I'd post this in case somebody took the whole notion one step further and decided to embark on a full blown "Cactihuasca" trip to the ER

 

[Deleted member 193777]

What are the amounts of kaempferol and Quercetin present in bridgesii, how selective are they as MAOIs and is there presence significant enough to inhibit MAO to the degree needed for oral DMT? I'm just not sure about that. By all means give it a try though!

Definitely, that's what I'd like to do, but I was wondering what a good amount of crystal DMT would be in that case... also, I haven't had a full T. Bridgesii experience yet so I'd like to have that first before enhancing it per se.

If anyone has experience with this, please chime in. :D Also, if anyone has smoked DMT during a T. bridgesii experience, please share as well.

Slightly OT, but I feel it should be mentioned that combining foreign MAOIs with various cacti might result in a hypertensive crisis. Taking Bridgesii alone with oral DMT is probably safe, but adding new MAOIs to the mix could be potentially fatal. Here's something from Erowid that might be useful: Are MAOIs dangerous in combination with some Trichocereus cacti?

Thought I'd post this in case somebody took the whole notion one step further and decided to embark on a full blown "Cactihuasca" trip to the ER

Thank you for this commentary - you brought up something very significant. I definitely would not add any extra MAOIs to the mix.

Also, does anyone know whether Kaempferol and Quercetin are reversible or irreversable MAOIs?