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Synergising Chemistry to find the "MAGIC"

Yeah, i don't know - for most people, combining psychedelic substances isn't a surefire way to have a good time, its a pretty unpredictable type of high. I'm looking for a way to find that magical experience that you share with good friends, not inside your own head.
 
MrIbis said:
Dude, this thread aint about psychedelic substances. anyone intending to take an MDxx substance with DXM is retarded...
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I had actually considered this at one stage (low dose DXM) given the lack of quality pills at the moment (yes I know it's a dangerous combo, no I'm not going to try it anytime soon). I did a little searching and stumbled across this old thread that reminded me exactly why I started browsing BL in the first place :D

http://www.bluelight.ru/vb/showthread.php?t=54540

Check out the posts by sneak2; interesting stuff! The posts on detoxification might be worth a read if you're considering any combo of "synergistic" chemicals?

Sorry to derail your thread a little MrIbis but can anyone add anything further to those posts with more up-to-date research given they were made in 2001?
 
all good belarki. Theres some interesting information in there, especially the stuff about milk thistle and ginkgo, few things i never knew - mainly because im far more into biochemistry/pharmacology than that stuff - and to me that seemed more important from a scientific POV than taking a few, as i saw them, crappy herbs.

But from what that says, if it is indeed true/correct alot of what could be called losing the magic - which as i believed from my own personal theories - that rolling was destroying the serotonin pathways in the brain and possibly tearing at the receptors, to the point where your brain just can't achieve that high anymore. And i feel in some way, although that is quite dumbed down - i am correct.

If ginkgo biloba has the potentical to heal those pathways, and perhaps create new pathways im all for it. Obviously that would also be an important part of creating the right subjective body chemistry for this whole ordeal to work far more effectivley. And the protective qualities of milk thistle could be extremely beneficial to long term health - and perhaps short term if its able to boost the enzyme/metabolic system - really help provide some protection from possible neurotoxicity/serotonin syndrome as a result of their experiments
 
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i had a magical experience in what was a series of very drab uninspiring settings. the thing is that mdppp is know as a ritalin type high but even at high doses it can be quite stoning and lacks anxiety and paranoia that are commonly a function of mdpv. though if you eat a lot of it on your own you'll be up for ages, snorting produces a short lived rush and binge pattern which is not worth it.

this was the first time i combined the two and i was very drunk but when i came up on the combo it overrided the alcohol and i felt childlike excitement. the desire to redose with the mdppp was not there to the same extent.
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Pofacedhoe have your tried the combo again since. This is something I may be interested in.
 
pofacedhoe said:
MDPPP is nothing like this on its own (very dopaminergic relative of MDPV) and MDAI is bland sedating serotonin release

together simply beautiful

what a great combo
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I believe MDAI would be great and very MDMAish with any decent DA/NE substrate.

IMO MDAI + d-amphetamine would be a huge winner, on par with mdma I'm sure, if not, then even better due to greater stimulation of amphet on it's own.

Combo's I think would also work and be relatively safe. MDAI + bk-mdma and MDAI + 3-FMC(strong dopamine affinity).

Just a few questions for ya pofacedhoe. How long did the effect of MDAI on its own last at 150mg? Also did your combo of MDPPP + MDAI peak as long as a reasonable dose of MDMA?
 
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^ that is not entirely correct MDxx compounds are everywhere, dependant on who you know or how daring you are to order them.

however, MD(MA) is in short supply - leaving us with the problem, and hypothetical idea of using 5HT releasing drugs with DA agonists.
 
Well even if there was mdma around, I would still play around with combos. The advantage of using these two drugs that have different affinitys to dopamine and sertonin means, I have more control over the chemistry in my brain by finding a balance that suits me. As with mdma, it's about how much to take vs side effects, one being depression 2 days later. I find methylone is alot more forgiving on the tuesday blues and since mdai is non toxic, the two together may end up being less toxic, less depression with all the wanted positive effects.
 
thestudent14 said:
Combos can be dangerous don't forget that :P
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Being alive is dangerous bro. ;)


I don't mean to down play the risks, but I don't believe mixing two similar drugs methylone and mdai is any greater risk than mdma in equal potency on it's own. The toxicity of these substrate releasing compounds comes in with ridiculous amounts of DA/SE release, hyperthermia and other indirect health issues such as water intoxication, cardio toxicity, heavier load on the liver, etc. If it situation can be controlled to prevent all of the above, I can't see any real danger. Well relatively speaking, drinking a bottle of wine is more likely to end up in more hurt at the end of the day.
 
^Whilst it is thought these chemicals aren't as toxic as their parent compounds, our research into things like mephedrone has proven otherwise (not that i'm saying methylone feels anywhere near as toxic when taken personally) - So there are some risks to consider, and just considering MDMA risks might not be enough.
 
If it situation can be controlled to prevent all of the above, I can't see any real danger. Well relatively speaking, drinking a bottle of wine is more likely to end up in more hurt at the end of the day.
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When, as in this case, there are few anecdotal accounts, how can you be sure potentiation or synergism doesn't exist with such a combination without first understanding the pharmacology and reviewing the pre-clinical evaluation? Comparing unknown pharmacology (i.e. guessing) to the known effects from alcohol and implying the latter is worse, is, I'm sorry to say, bordering on the ridiculous.

We don't know about preferential binding with these substances when taken together at various dosages, we don't know whether MAO or reuptake inhibition may be increased, we don't know whether sympathomimetic actions will be increased leading to possible cardiovascular probs, or if hypothalamic activity is significantly altered , etc etc...

One thing we do know. MDAI is relatively non-toxic on it's own, where as MDMA with it's DA activity is neurotoxic; DA increases being an important factor in 5HT axon damage.

MDAI and M1 or 3FMC may turn out to be relatively safe combinations, but until we have some definite proof, there's not a lot of sound HR advice in advocating any new combination as being safer than red wine.
 
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