I never really knew what anxiety was until I had rolled about a dozen times.
Then there was Serotonin Syndrome - which could be described as the most MASSIVE anxiety attack possible by ANY human being.
It is so powerful, that some people DIE from it.
Coming up on MDMA sees an 800% increase in cortisol levels.
Dopamine also goes up, which is related to anxiety issues.
After rolling, the loss of serotonin function can cause anxiety in some people.
But interestingly, some people do experience relief for these few days - a sign that their serotonin network is causing anxiety most of the time.
By lowering the network activity, relief is felt.
In fact, rolling itself is a practice in lowering serotonin.
Sure, it spikes first - BIG TIME.
But then, it falls off.
It is after the 'peak' that the real 'magic' begins.
So the lessening of anxiety from rolling, whether in a normal person or not, is likely due to a DROP in serotonin.
But it won't stay that way.
When it starts to come back, many people describe mild fluctuations in mood.
A minority of us develop SEVERE anxiety, leading to depression or psychosis.
If the MDMA dose is high enough, or repeated enough times, it is believed that it causes the entire network to 'reorganize' itself - leaving higher cortical regions with lower density of innervation.
Doesn't sound like a great idea.
But there is no reason to assume that a REASONABLE dose (100-150mg) of PURE MDMA would cause such 'injury' - even in a person with anxiety.
But you should DAMN well expect a rebound effect that is rather difficult.
Count on it.