Sudden loss of benzo euphoria, why? NOT tolerance.

[Supeudol]

Apologies for the length of the post but I though perhaps the following details might be relevant to the question.

From june of last year to the current day I have been in a seesaw addiction process between alcohol, benzo's and GBL. This was due to the fact that I would become dependent on GBL and detox with benzos, only to become so euphoric and uninhibited by the benzos that I would take high doses for around 2 weeks (~100mg diazepam a day, although it began with a month long period wherein I consumed something like 300-350mg alprazolam), run out of benzos, feel okay for a week or so as the diazepam left my system and then enter withdrawals whereupon I would turn to GBL to treat the withdrawals until I could obtain more benzos (2-3 weeks).

This cycle persisted until last december at which point the benzo wd's were so intense that even high dose GBL did not alleviate the paranoia and insomnia (4-5ml would not even get me to sleep, whereas before that anything over 1ml would knock me out). At the time this happened I had though it was due to G tolerance, having been off valium for around 2 weeks. At this point I found 20mg diazepam, took 10mg (while still on the G) and found that my symptoms alleviated somewhat, and another 10mg made me feel normal. This lasted for a little over a day.

Anyway, a week or so later (having taken the odd mg of alprazolam to keep the wd's at bay) I obtained more diazepam but found that I experienced no euphoria. I'm currently off GBL and on a diazepam taper (down to 10mgs) but it still remains that no amount of diazepam makes me euphoric. Higher doses (up to 40mg) will cause cognitive dysfunction and disinhibition but no euphoria.

I was wondering if anyone could explain this, possibly in the light of my on-off GBL and diazepam usage? It's not tolerance; it was a sudden change in my response to diazepam - one day it could get me high, a week later, nothing.

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I deleted and reposted this with a clearer title in the hopes of getting an educated answer from someone.

You are not getting Euphoria from you benzo's because your GABA-A Receptors are probably pretty depleted and hammered on hard, and the alcohol didn't help either.

Now as for the fact that you are asking if GBL might play a role in not being able to feel euphoria off of benzo's anymore? The answer is no. GHB/GBL act on the GABA-B Receptors, and the GHB receptor. GHB/GBL also inhibit Dopamine in lower doses, and in higher doses block Dopamine.

Your situation sounds extremely similar to some of my situations I have had in the past and 'current'. The best thing to try and do is to lay off the GABA drugs, but if you have been taking high dose benzodiazepines like that for a long time you definitely need to be doing a taper. IMO, GHB/GBL is far safer for you than benzodiazepines, and is also 100x more euphoric. But anyway, remember to drink lots and stay hydrated. Eat good foods, lots of vegetables and fruit. Benzo withdrawal sucks man, my heart goes out to you. I have been through it, and am currently about 6 months clean (except for a few diazepam, and bromazepam to try and kick my oxycodone habit for the third time.)

I too was taking high doses of benzo's as well, but for me it was more Lorazepam (Ativan) than anything else as far as I can remember. I still feel withdrawal symptoms - like some times mild tremors, and (Extremely sensitive skin, goosebumps up & down my arms, and cold sweats underneath my arms - which could not be related to benzo wihthdrawal but perhaps something else like a pinched nerve in my C-Spine as I wait for a call to have my M.R.I. appointment setup. Could be a hormone problem as well, or something in my adrenal glands. Although I have had my doctor do blood testss even for Cortisol levels and what not.

Anyways, sorry if this does not make total sense as I am nodding off as I am writing this, damn opiates I been trying to kick again for the third time. Sometimes things are just to pleasurable. Its almost 4:30AM here.

All the best to you ~mate! PM me if you want to chat further on instant mesaging tools.

Cheers and good luck!

 

[kaossalami]

If you go through a period where you're using high amountz of a benzo, most likely your tolerance will rise..subduing most side effects (euphoria) because of that single 2 week period. I abused valium wayy to much over two weeks, I don't remember those days very much but I can say my tolerance is rediculous because of it. This was 3 months ago. I no longer get any buzz or euphoria from benzos

 

[Phener]

..from your original post - I would be far more worried about addiction + tolerance over ANY amount of "euphoria" if one can call it that associated with benzos

 

[Captain.Heroin]

I would take high doses for around 2 weeks (~100mg diazepam a day, although it began with a month long period wherein I consumed something like 300-350mg alprazolam), run out of benzos, feel okay for a week or so as the diazepam left my system and then enter withdrawals whereupon I would turn to GBL to treat the withdrawals until I could obtain more benzos (2-3 weeks).

You have what I would colloquially call "perma-tolerance" to benzos. You report sudden loss of benzo euphoria, and you used to take them in massive amounts.

This happens to a lot of people who have used benzos in excess.

 

[/navarone/]

It can be also tollerance but..

"Even pussy looses its magic if you fuck it too often."

Hope that explains it...

 

[GrimeyMcGrimerson]

Im not going to try and bullshit with the pharmacology and the reactions and all that shit, all I know is I was addicted to valium and really really dependant on xanax for about 3 years. Best feeling ever was the first time I felt the euphoria of the valium. I was also addicted to oxies so was accustomed to the overwhelming euphoria. After about 3 months with the valium it just completely lacked the euphoria. It seemed almost overnight. I wasnt high. Everything just seemed like a rainy day when I took it. I would just fall asleep if I took more. Topped out at about 60mgs at a time. Same thing happened with xanax about 2 years later. When the oxy stopped working mixing in a few bars got me feeling pretty good. Soon the xanax became the priority as the opiates ceased to work. I remember i would keep overdosing on the xanax because i would take 5 1/2 bars at a time, not get high, but black out and continue to pop them in my black out attempting to recreate that ol feeling of euphoria. It just wasnt there anymore. I would end up taking half a bottle and stop breathing. It does just stop working. Do yourself a favor and stay off of them for a while and give your body a chance at learning how to regulate your feelings and especially your anxiety on its own. I know it seems hard, but it will happen. Meditation is very helpful. Good luck!!!