Bupe Suboxone vs. Methodone

[SM0K3Y]

Naloxone is a 2nd antagonist, as well as the bupe. The bupe clings to receptors (we all know this) and so does naloxone. The thing is though, what some people have been wrongly told, is that naloxone is only administered when you IV and it won't be administered if you snort or use it sublingual. You do get some amount of it when you take the suboxone no matter what way (more so if you snort than under your tongue) Not only are you receiving 8mg's of bupe, but you are also getting 2mg's of naloxone (all of which may not be soluble through the lining of your mouth since it doesn't bind as great as bupe does)

Regardless you are adding a 2nd antagonist. And I can promise you that they didn't get "Higher" - they may have had the bupe nods on top of a regular opiate, but I can promise you the blocking from the bupe on their receptors (as well as the naloxone) would not allow them to get as high.

What you may be talking about however, is when you take an opiate on top of methadone or subs and it keeps the withdrawals away for longer, you get a longer feeling of being decent and not sick, but there is no way it would have made them higher. It would have just added extra opiates/opioids to be burnt off before being sick again (I used to snort dope and sub together as a matter of fact to make it last the longest)

Other than that, it would just make you sleepy and tired. Not euphoric.

 

[Tommyboy]

^ Trust me man, suboxone blocks opiates from working for me forever (well, 3 days) so I'm the first to tell people to wait 2-3 days before dosing again. Recently I had taken a single 1mg dose of suboxone, and later than day I took some oxycodone and it felt like a mixture between the two, but who know. I was nodding for sure, but it wasn't all that euphoric.

Back to the naloxone topic though: The half-life of naloxone is so short (1-1.5hr) that even if it did bind to the receptors, it would only keep people from getting high for a couple of hours after their last dose.