^ that sounds a little to easy....man, my doctor requires drug testing and counseling, but its all in the same building.....its actually quite a good program.....
I just wanted to comment on the people who have to take drug tests for bupe. I have a doctor who does not drug test nor does he require counseling. I just see him once a month walk in pay my X cash get my scrip walk out takes maybe 15 minutes tops. So they are out there you just have to do a little investigating. He didnt even do a drug test for my first appointment and he allowed me to do my induction at home. I will say he is totally in it for the income though.
please stop saying the Naloxone in Suboxone is innert or inactive.
Goggle "BupPharm" and read the power point at the top. It clearly shows Naloxone is active in Suboxone.
I also have 2 other PDF's that clearly show that a small amount of Naloxone gets through in most people, and even a small amount has an effect on your CNS for an hour or two.
So from reading that power point, if you take Buprenorphine alone (Subutex), you will be high very quickly (15 to 30 min), but if you take Suboxone sublinguly it will take a few hours to get to the max high.
Even if your argument was true that all the receptors were "full" of Buprenorphine (saturated) so no Naloxone can find a free opiate receptor, (which is not true in most cases), Naloxone will go and find TLR4 receptors, and that has an effect on your CNS.
Goggle "Naloxone TLR4" if you want to know more.
I must explain something: there are millions of opiate receptors in your brain, so when you take Suboxone, depending on dose, and frequency, a lot of receptors will have Buprenorphine on them, and a few will have Naloxone on them, for a few hours. It is not one big on/off switch in your brain, as a few people seem to think.
Some lucky people seem to get no Naloxone from Suboxone. It depends on the amount of enzymes in your liver and gut. It also depends on what you ate before taking Suboxone - if I eat a blood red grape fruit an hour before taking my Suboxone, I feel the Naloxone more.
If I take Amitriptyline 10mg the night before, and eat a blood red grapefruit for breakfast, then have my Suboxone an hour later, I massively feel the Naloxone, and my pupils dilate massively, (normally very small), I have to run to the toilet for a massive shit, I start sweating like crazy, and I get lots of pain. I get all this symptoms or an hour or two, then the Buprenorphine kicks in, and I feel great the rest of the day.
So there are many factors determining if the Naloxone gets to your brain, or is broken down before then. It is very complicated.
I hope this cleared things up for a few people.
Copied from an ADD thread started today... Thoughts?
I always forget how when i jump down a bupe dose the first day isn't the worst, its more like the best and every day gets worse from there.
^ i am so much happier on 1mg than i was on 2mg.......i feel great....i have also noticed that the mental 'holding' is less on 1mg, so thats the only downside.....
I'm on day 5 of my suboxone detox. I quit cold turkey off of 4-8mg a day. How loong is this seriously going to last?
Copied from an ADD thread started today... Thoughts?
Can people here please confirm or deny this;
In the UK, we get prescribed Subutex only I believe. This is a drug with a rather unpleasant high but people not using Subutex get rather ripped from it and in prison a single 2mg pill sells for £x-£x.
In the USA, people get scripts for Suboxone. This drug gives no artificial high, but does stop heroin withdrawal and has similar properties to Subutex, but with a 'high blocker' attached to it. This high blocker, basically works by limiting the amount of bupe that can be absorbed by the opiate receptors at any given time. This is not true for Subutex.
Suboxone contains buprenorphine as well as the opioid antagonist naloxone to deter the abuse of tablets by intravenous injection. Controlled trials in human subjects suggest that buprenorphine and naloxone at a 4:1 ratio will produce unpleasant withdrawal symptoms if taken intravenously by patients who are addicted to opioids