I have recently been prescribed oral morphine for pains related to cancer. I was on oxycodone prior to this in 30, then 40mg tabs. The oral administration route seems to take a long time to take effect (about half hour to an hour for me). I had heard about rectally administering the oral morphine sul, but I am wondering can it be absorbed sublingually by placing the solution under your tongue. I know that the membranes in the mouth can absorb things like nicotine and certain other drugs and I was wondering if this would be true for morphine as well, also would that allow it to bypass the first pass metabolism?.
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BDD Moderators: Keif’ Richards
Sublingual absorption of Oral Morphine Sulphate
- Thread starter rm700
- Start date
Coraline
Bluelight Crew
I gets in the system faster sublingual. I do believe it bypass first pass as well. Morphine has a oral BA of 30% and rectal is the same. If the medication isn't working talk to your dr and let them know.
http://www.bluelight.ru/vb/threads/564885-Opioid-Conversion-Chart
http://www.bluelight.ru/vb/threads/564885-Opioid-Conversion-Chart
The rectal administration is actually higher, almost 2x as high as oral. Morphine always takes a little white to work for me, but it lasts a lot longer than oxycodone.
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Oxycodone, Yes. Morphine sulfate, no. Morphine seems like it's not lipid soluble enough to easily cross mucus membranes. Shit it's barely water soluble. IME it doesn't work, that or snorting. And it tastes like shit.
Opium does work though.
Opium does work though.
mindtools
Bluelighter
AFAIK morphine in opium is in other compound than sulphate
Swimmingdancer
Bluelight Crew
Apparently (according to this source) only the soluble tablets or the concentrated oral solution are suitable for sublingual use - morphine sulfate IR tablets will not work because they are not soluble and will not liquefy and absorb properly under the tongue. I'm not sure which type you have?
Apparently if you take them sublingually a portion of it will absorb through your mouth and kick in faster, and a portion of it will get swallowed and be absorbed like if it were taken orally normally. Not everyone reports good results with sublingual administration, (although maybe it depends on what type of morphine they have?), but generally people seem to have better results from plugging it (since you mentioned plugging).
Apparently if you take them sublingually a portion of it will absorb through your mouth and kick in faster, and a portion of it will get swallowed and be absorbed like if it were taken orally normally. Not everyone reports good results with sublingual administration, (although maybe it depends on what type of morphine they have?), but generally people seem to have better results from plugging it (since you mentioned plugging).
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